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anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) Antibodies

The protein encoded by LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LATS1 16798 Q8BYR2
LATS1 9113 O95835
LATS1 308265  
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Top anti-LATS1 Antibodies at antibodies-online.com

Showing 10 out of 75 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-LATS1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: THP-1 cell lysate WB Suggested Anti-LATS1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of anti-LATS1 Antibody (N-term) in K562 cell line lysates (35ug/lane). LATS1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-LATS1 Antibody (N-term) (ABIN391033) in K562 cell line lysates (35 µg/lane). LATS1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
$291.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of LATS1 expression in Hela (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$379.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$379.50
Details

LATS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LATS1 Antibodies

  1. Human Polyclonal LATS1 Primary Antibody for IHC (p), WB - ABIN391033 : Iida, Hirota, Morisaki, Marumoto, Hara, Kuninaka, Honda, Kosai, Kawasuji, Pallas, Saya: Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. in Oncogene 2004 (PubMed)
    Show all 6 references for ABIN391033

  2. Human Polyclonal LATS1 Primary Antibody for WB - ABIN2787626 : Zhang, Smolen, Haber: Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. in Cancer research 2008 (PubMed)

  3. Human Polyclonal LATS1 Primary Antibody for IF (p), IHC (p) - ABIN872292 : Grijalva, Huizenga, Mueller, Rodriguez, Brazzo, Camargo, Sadri-Vakili, Vakili: Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration. in American journal of physiology. Gastrointestinal and liver physiology 2014 (PubMed)

  4. Human Polyclonal LATS1 Primary Antibody for EIA, IHC (p) - ABIN359091 : Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. in Blood 2008 (PubMed)

More Antibodies against LATS1 Interaction Partners

Zebrafish LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. Thus AMOT (show AMOT Antibodies) is a direct substrate of Lats1/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.

  2. lats genes show distinctly different expression profiles during gastrulation. lats1 is almost ubiquitously expressed through development, and lats2 (show LATS2 Antibodies) is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula.

Mouse (Murine) LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. Results showed that the Hippo pathway is active in ovarian follicles and that LATS1 is required to maintain the pool of germ cells and primordial follicles.

  2. The control of LATS activation by angiotensin II and subsequent YAP (show YAP1 Antibodies) localization is important for podocyte homeostasis and survival.

  3. Willin (show FRMD6 Antibodies) is predominantly expressed in fibroblasts and that Willin (show FRMD6 Antibodies) expression activates the Hippo signaling cascade

  4. LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization.

  5. KIBRA (show WWC1 Antibodies) associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  6. Lats1 enhances the activity of FOXl2 (show FOXL2 Antibodies) as a repressor of the StAr promoter. st

  7. Overexpression of YAP2 (show YAP1 Antibodies) in cells promoted apoptosis, whereas the Mst2 (show STK3 Antibodies)/Lats1-induced phosphorylation of YAP (show YAP1 Antibodies) partially rescued the cells from apoptotic death.

  8. Genome-wide location arrays in cell lines of various cell types revealed that Lats1 was a transcriptional target of CUX1 (show CUX1 Antibodies).

Human LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. PARD3 (show PARD3 Antibodies) promotes interaction between PP1A (show PPP1CA Antibodies) and LATS1 to induce LATS1 dephosphorylation and inactivation,leading to dephosphorylation and activation of TAZ (show TAZ Antibodies)

  2. Loss of LATS1 expression is associated with breast neoplasms.

  3. Phosphorylation of CHO1 (show KIF23 Antibodies) at S716 by Lats1 regulate its centrosomal localization, and that phosphorylated CHO1 (show KIF23 Antibodies) interacts with and activates LIMK1 (show LIMK1 Antibodies) during early mitosis.

  4. LATS1 phosphorylates the Thr7 residue of the APC (show APC Antibodies)/C component CDC26 (show CDC26 Antibodies) directly

  5. These results demonstrated that as an inhibitor of YAP (show YAP1 Antibodies), LATS1 was decreased via downregulation of YAP (show YAP1 Antibodies) using RNAi. This therefore indicated that the change in YAP (show YAP1 Antibodies) levels in hepatocellular carcinoma cells may regulate LATS1 in a feedback manner.

  6. LATS1 promoter hypermethylation is associated with oral squamous cell carcinomas.

  7. results reported here further support that LATS1/2 act normally as tumor suppressors and loss of their functions contributes to human cancer development

  8. Phosphorylation of S716 NDR (show STK38 Antibodies)/LATS, present only in the longest Kif23 (show KIF23 Antibodies) isoform, is required for phosphorylation at S814, revealing phosphorylation at these two sites, and differential regulation of Kif23 (show KIF23 Antibodies)-14-3-3 (show YWHAQ Antibodies) interaction for the two Kif23 (show KIF23 Antibodies) isoforms.

  9. Findings suggest that polyomavirus middle T-antigen (PyMT) activates the Hippo pathway tumor suppressor Lats in a Src (show SRC Antibodies)-dependent manner.

  10. LATS1 and LATS2 (show LATS2 Antibodies) kinases play an important role in the regulation of NS5A function through site-specific post-translational modification and that phosphorylation of Ser (show SIGLEC1 Antibodies)/Thr71 is essential for optimal viral genome replication.

LATS1 Antigen Profile

Protein Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Gene names and symbols associated with LATS1

  • LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) antibody
  • LATS, large tumor suppressor, homolog 1 (Drosophila) (lats1) antibody
  • LATS, large tumor suppressor, homolog 1 (TEgg117h14.1) antibody
  • large tumor suppressor (Lats1) antibody
  • large tumor suppressor kinase 1 (LATS1) antibody
  • large tumor suppressor kinase 1 (Lats1) antibody
  • AW208599 antibody
  • Lats antibody
  • lats1 antibody
  • RGD1564085 antibody
  • si:dkey-181i3.5 antibody
  • WARTS antibody
  • wts antibody
  • wu:fc19a11 antibody
  • zgc:123219 antibody

Protein level used designations for LATS1

large tumor suppressor , serine/threonine-protein kinase LATS1 , LATS homolog 1 , LATS, large tumor suppressor, homolog 1 , LATS, large tumor suppressor, homolog 1 (Drosophila) , serine/threonine-protein kinase LATS1-like , WARTS protein kinase , large tumor suppressor homolog 1 , large tumor supressor, homolog 1 , LATS (large tumor suppressor, Drosophila) homolog 1 , h-warts , large tumor suppressor 1

GENE ID SPECIES
100060397 Equus caballus
553164 Danio rerio
748397 Pan troglodytes
100145677 Xenopus (Silurana) tropicalis
100410314 Callithrix jacchus
100455398 Pongo abelii
100467078 Ailuropoda melanoleuca
100539393 Meleagris gallopavo
100599863 Nomascus leucogenys
16798 Mus musculus
9113 Homo sapiens
308265 Rattus norvegicus
421627 Gallus gallus
100152165 Sus scrofa
535935 Bos taurus
476241 Canis lupus familiaris
Selected quality suppliers for anti-LATS1 (LATS1) Antibodies
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