anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) Antibodies

LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LATS2 50523 Q7TSJ6
LATS2 305922  
LATS2 26524 Q9NRM7
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Top anti-LATS2 Antibodies at antibodies-online.com

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with LATS2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. The anti-LATS2 Pab is used in Western blot to detect LATS2 in NIH/3T3 cell lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using LATS2 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using LATS2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-LATS2 Pab (ABIN391034) is used in Western blot to detect LATS2 in NIH/3T3 cell lysate. Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with LATS2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, PLA, WB Detection of Human LATS2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 1/4 of IP loaded/lane) from HeLa cells. Antibodies: ABIN152335 used at 0.4 mcg/ml (A) and 1 mcg/ml (B) for WB and at 3 mcg/mg lysate for IP. LATS2 was also immunoprecipitated by another LATS2 antibody, which is an affinity purified antibody to a downstream epitope from LATS2. Detection: Chemiluminescence with an exposure time of 30 seconds (A and B). Proximity Ligation Assay: LATS2 Antibody [ABIN152335] - Secondary-conjugate Duolink In Situ PLA in Hela cells. goat anti-human CHK1 (ABIN152335) and rabbit anti-human LATS2 (ABIN152335). Image merged from DAPI (2ms), FITC/Green (25ms) and TRITC/Orange (250ms) exposures, 40X magnification. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Mouse Rabbit Un-conjugated WB Mouse Lats2 Antibody (C-term) (ABIN1881491) western blot analysis in mouse testis tissue lysates (35 µg/lane). This demonstrates the Mouse Lats2 antibody detected the Mouse Lats2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse heart labeled with Rabbit Anti phospho-LATS2 (Ser83) Polyclonal Antibody, Unconjugated (ABIN753568) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Anti-LATS2 (Ser83) Polyclonal Antibody, Unconjugated  at 1:300 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat heart labeled with Anti LATS2 Polyclonal Antibody, Unconjugated (ABIN753553) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti-LATS2 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Mouse Un-conjugated WB Western Blot: LATS2 Antibody (2D3) [NBP2-45612] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LATS2. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

LATS2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LATS2 Antibodies

  1. Human Polyclonal LATS2 Primary Antibody for IP, PLA - ABIN152335 : Kilili, Kyriakis et al.: Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 ... in The Journal of biological chemistry 2010 (PubMed)
    Show all 14 references for 152335

  2. Mouse (Murine) Polyclonal LATS2 Primary Antibody for WB - ABIN1881491 : Oh, Lee, Kim, Kim, Oh, Hwang, Kong, Kwon, Lim: Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. in Molecular and cellular biology 2009 (PubMed)
    Show all 4 references for 1881491

  3. Human Polyclonal LATS2 Primary Antibody for IF, IHC - ABIN1534144 : Hori, Takaori-Kondo, Kamikubo, Uchiyama: Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. in Oncogene 2000 (PubMed)
    Show all 3 references for 1534144

  4. Human Polyclonal LATS2 Primary Antibody for IHC (p), WB - ABIN391034 : Blume-Jensen, Hunter: Oncogenic kinase signalling. in Nature 2001 (PubMed)

  5. Human Polyclonal LATS2 Primary Antibody for EIA, IHC (p) - ABIN359092 : Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001 (PubMed)

More Antibodies against LATS2 Interaction Partners

Mouse (Murine) LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) interaction partners

  1. The findings reveal a novel signal upstream of PRC2, and provide insight into the crucial role of LATS2 in coordinating the epigenome through regulation of PRC2.

  2. Study demonstrates that, in 3 different murine syngeneic tumor models (B16, SCC7, and 4T1), loss of the Hippo pathway kinases LATS1 (show LATS1 Antibodies)/2 (large tumor suppressor (show LATS1 Antibodies) 1 and 2) in tumor cells inhibits tumor growth; data indicate a new paradigm for how tumor immunogenicity is regulated through the Hippo signaling pathway in tumor cells.

  3. mice harboring liver-specific Lats2 conditional knockout (Lats2-CKO) displayed constitutive SREBP activation and overexpressed SREBP target genes and developed spontaneous fatty liver disease

  4. protein and mRNA expression of the MST1 (show MST1 Antibodies) and LATS2 were decreased significantly as mouse age increased (p < 0.05), however, the mRNA expression of them increased significantly in 16 m compared with 5 m as well as the protein expression of LATS2.

  5. Lats2 is recruited to the p53 (show TP53 Antibodies) pathway to coordinate proper transcriptional reprogramming.

  6. Lats2 regulates the balance between proliferation and differentiation during adipose development.

  7. miR (show MLXIP Antibodies)-302a plays a critical role in mediating the effects of folate on cell proliferation and cell cycle-specific apoptosis by targeting Lats2 gene.

  8. KIBRA (show WWC1 Antibodies) associates with and activates Lats (large tumor suppressor (show LATS1 Antibodies)) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  9. Lats2 plays an essential mitotic role in coordinating accurate cytokinesis completion, governing the stabilization of other mitotic regulators

  10. Lats2 affects both growth and death of cardiac myocytes, but it primarily regulates the size of the heart and acts as an endogenous negative regulator of cardiac hypertrophy.

Human LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) interaction partners

  1. The findings reveal a novel signal upstream of PRC2, and provide insight into the crucial role of LATS2 in coordinating the epigenome through regulation of PRC2.

  2. PVT1 recruits EZH2 (show EZH2 Antibodies) to the large tumor suppressor (show LATS1 Antibodies) kinase 2 (LATS2) promoter and represses LATS2 transcription.

  3. findings reveal a non-canonical (that is, YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies)-independent) effect of LATS (show LATS1 Antibodies) in the regulation of human breast cell fate

  4. LATS2 as the direct target of miR (show MLXIP Antibodies)-372 in prostate cancer cells.

  5. Data suggest that, at least using the commercial antibodies used in this study, immunohistochemical staining for NF2 (neurofibromin 2 (show NF2 Antibodies)), LATS2 (large tumor suppressor (show LATS1 Antibodies) kinase 2), and YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) (nuclear translocation of complex of Yes-associated protein [YAP (show YAP1 Antibodies)] with transcriptional coactivator with PDZ-binding motif (show WWTR1 Antibodies) [TAZ (show TAZ Antibodies)]) is not helpful for differential diagnosis of mesothelioma versus a benign proliferation.

  6. overexpression of LATS2 resulted in mobility inhibition in non-small cell lung cancer cell lines A549 and H1299, and reduced protein level of matrix metalloproteinase-2 (MMP-2 (show MMP2 Antibodies)) and MMP-9 (show MMP9 Antibodies).

  7. LATS2 was found to have binding sites for miR (show MLXIP Antibodies)-135b in the 3'UTR (show UTS2R Antibodies) region and results demonstrated that LATS2 is a direct target of miR (show MLXIP Antibodies)-135b which regulates its expression in breast cancer cells.

  8. Characterisation of LATS2 variants uncovers novel insights into the regulation of LATS (show LATS1 Antibodies) kinases in Hippo signalling.

  9. LATS2 could be induced by TNF-alpha (show TNF Antibodies) and inhibited cell proliferation and invasion by phosphorylating YAP (show YAP1 Antibodies) in OSCC cells.

  10. our current data indicated a new regulatory mechanism of YAP1 (show YAP1 Antibodies) by the LATS2-mediated phosphorylation that was involved in hepatocellular carcinoma tumorigenesis.

Zebrafish LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) interaction partners

  1. Thus AMOT (show AMOT Antibodies) is a direct substrate of Lats1 (show LATS1 Antibodies)/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.

  2. lats (show LATS1 Antibodies) genes show distinctly different expression profiles during gastrulation. lats1 (show LATS1 Antibodies) is almost ubiquitously expressed through development, and lats2 is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula.

Pig (Porcine) LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) interaction partners

  1. The lats2 exhibit inverted expression to YAP1 (show YAP1 Antibodies), another member of the Hippo pathway which positively regulates cell growth and proliferation, during the differentiation of 3T3-L1 preadipocytes.

LATS2 Antigen Profile

Protein Summary

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Gene names and symbols associated with LATS2

  • LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2) antibody
  • large tumor suppressor 2 (Lats2) antibody
  • large tumor suppressor kinase 2 (LATS2) antibody
  • LATS, large tumor suppressor, homolog 2 (Drosophila) (lats2) antibody
  • 4932411G09Rik antibody
  • AV277261 antibody
  • AW228608 antibody
  • KPM antibody
  • lats2 antibody

Protein level used designations for LATS2

kinase phosphorylated during mitosis protein , large tumor suppressor homolog 2 , serine/threonine-protein kinase LATS2 , serine/threonine-protein kinase kpm , large tumor suppressor, homolog 2 , LATS (large tumor suppressor, Drosophila) homolog 2 , LATS, large tumor suppressor, homolog 2 , serine/threonine kinase KPM , warts-like kinase , large tumor suppressor 2-like protein

GENE ID SPECIES
100050150 Equus caballus
50523 Mus musculus
305922 Rattus norvegicus
26524 Homo sapiens
508208 Bos taurus
567674 Danio rerio
418949 Gallus gallus
477343 Canis lupus familiaris
100415907 Sus scrofa
Selected quality suppliers for anti-LATS2 (LATS2) Antibodies
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