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anti-LEM Domain Containing 3 (LEMD3) Antibodies

This locus encodes a LEM domain-containing protein. Additionally we are shipping LEM Domain Containing 3 Proteins (3) and LEM Domain Containing 3 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LEMD3 23592 Q9Y2U8
LEMD3 680066  
LEMD3 380664 Q9WU40
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Top anti-LEM Domain Containing 3 Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunohistochemistry of LEMD3 in human colon tissue with LEMD3 antibody at 2.5 ug/mL. Western blot analysis of LEMD3 in human colon tissue lysate with LEMD3 Antibody  at 1 ug/mL. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. Flow cytometric Analysis of Hela cells, using anti-LEMD3 antibody (ABIN2453808), (Red), compared to a nonspecific negative control antibody, (Blue). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-LEMD3 mouse monoclonal antibody. (ABIN2453231, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-LEMD3mouse monoclonal antibody. (ABIN2453231, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, IP, WB Anti-LEMD3 mouse monoclonal antibody (ABIN2453229) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3 (RC212759). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. Immunohistochemical staining of paraffin-embedded liver tissue using anti-LEMD3mouse monoclonal antibody. (ABIN2453228, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IP, WB Anti-LEMD3 mouse monoclonal antibody (ABIN2453230) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3 (RC212759). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated FACS, IF, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 8 to 10 Days
$529.83
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB   50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated FACS   100 μL Log in to see 8 to 10 Days
$493.17
Details

LEMD3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,
,
,
Rat (Rattus)


Mouse (Murine)


Top referenced anti-LEM Domain Containing 3 Antibodies

  1. Human Polyclonal LEMD3 Primary Antibody for EIA, IF - ABIN1450079 : Hellemans, Preobrazhenska, Willaert, Debeer, Verdonk, Costa, Janssens, Menten, Van Roy, Vermeulen, Savarirayan, Van Hul, Vanhoenacker, Huylebroeck, De Paepe, Naeyaert, Vandesompele, Speleman, Verschueren, Coucke, Mortier: Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. in Nature genetics 2004 (PubMed)

More Antibodies against LEM Domain Containing 3 Interaction Partners

Pig (Porcine) LEM Domain Containing 3 (LEMD3) interaction partners

  1. Genome-wide analysis combined with linkage results revealed LEMD3 and WIF1 (show WIF1 Antibodies) as the candidates for porcine ear size.

Human LEM Domain Containing 3 (LEMD3) interaction partners

  1. A novel mutation in LEMD3 splice site results in Buschke-Ollendorff syndrome.

  2. Data indicate that the inner nuclear membrane protein MAN1 directly binds the transcription activator BMAL1 (show ARNTL Antibodies) promoter and enhances its transcription.

  3. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Antibodies) signaling in which MAN1 competes with transcription factors for binding to Smad2 (show SMAD2 Antibodies) and Smad3 (show SMAD3 Antibodies) and facilitates their dephosphorylation by PPM1A (show PPM1A Antibodies).

  4. The absence of direct binding of BAF (show BANF1 Antibodies) to MAN1-C eliminates disruption of this interaction as the cause of the premature aging phenotype.

  5. Genetic analyses of three generations of a family with Buschke-Ollendorff syndrome having a variable phenotype showed a novel c.2203C>T nonsense mutation at the LEMD3 locus. The mutation induced a change in the 735 arginine codon to a stop codon.

  6. Buschke-Ollendorff syndrome in a three-generation family: influence of a novel LEMD3 mutation to tropoelastin (show ELN Antibodies) expression.

  7. We found a novel c.2203C > T (p.R735X) mutation in exon 9 of LEMD3, resulting in a premature stop codon at amino acid position 735.

  8. Absence of LEMD3 mutation in the exons and splice sites of a family with BOS suggests that there is genetic heterogeneity for this disorder.

  9. Binds to Smad2 (show SMAD2 Antibodies) and Smad3 (show SMAD3 Antibodies) and antagonizes signaling by transforming growth factor-beta

  10. Overexpression results in inhibition of R-Smad (show SMAD1 Antibodies) phosphorylation, heterodimerization with Smad4 (show SMAD4 Antibodies), and nuclear translocation

Mouse (Murine) LEM Domain Containing 3 (LEMD3) interaction partners

  1. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Antibodies) signaling in which MAN1 competes with transcription factors for binding to Smad2 (show SMAD2 Antibodies) and Smad3 (show SMAD3 Antibodies) and facilitates their dephosphorylation by PPM1A (show PPM1A Antibodies).

  2. the heterozygous Lemd3 gene-trapped mouse is not a good model to study osteopoikilosis and the Buschke-Ollendorff syndrome.

  3. In Man1-deficient embryos, the expression of Tgfb1 (show TGFB1 Antibodies) is upregulated and Smad2 (show SMAD2 Antibodies)/3 signaling is abnormally activated, resulting in increased extracellular matrix deposition, a hallmark of the resolution phase of angiogenesis.

  4. The nuclear envelope protein (show SUN2 Antibodies) MAN1 regulates TGFbeta (show TGFB1 Antibodies) signaling and vasculogenesis in the embryonic yolk sac (show ADCY10 Antibodies).

  5. Man1 regulates left-right asymmetry by controlling Nodal signaling in a node-independent manner

LEM Domain Containing 3 (LEMD3) Antigen Profile

Protein Summary

This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

Gene names and symbols associated with LEMD3

  • LEM domain containing 3 (LEMD3) antibody
  • LEM domain containing 3 (lemd3) antibody
  • LEM domain containing 3 (Lemd3) antibody
  • AI316861 antibody
  • im:7158446 antibody
  • Man1 antibody
  • RGD1561001 antibody
  • sane antibody
  • si:dkey-6a5.6 antibody
  • wu:fb34b12 antibody
  • xman1 antibody

Protein level used designations for LEMD3

LEM domain containing 3 , inner nuclear membrane protein Man1 , Smad1 antagonistic effector , LEM domain-containing protein 3 , integral inner nuclear membrane protein , integral inner nuclear membrane protein MAN1

GENE ID SPECIES
417832 Gallus gallus
452050 Pan troglodytes
530659 Bos taurus
558474 Danio rerio
717597 Macaca mulatta
100038042 Xenopus (Silurana) tropicalis
100079476 Ornithorhynchus anatinus
100346960 Oryctolagus cuniculus
100402143 Callithrix jacchus
100441107 Pongo abelii
100511508 Sus scrofa
100553511 Anolis carolinensis
23592 Homo sapiens
608380 Canis lupus familiaris
680066 Rattus norvegicus
380664 Mus musculus
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