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Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. Additionally we are shipping LIM Domain Binding 1 Protein Proteins (6) and LIM Domain Binding 1 Protein Kits (3) and many more products for this protein.
Showing 10 out of 76 products:
Chicken Polyclonal LIM Domain Binding 1 Protein Primary Antibody for EIA - ABIN118013
Visvader, Mao, Fujiwara, Hahm, Orkin: The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 7 references for ABIN118013
Human Polyclonal LIM Domain Binding 1 Protein Primary Antibody for EIA, WB - ABIN953152
Howard, Ransom, Maurer: Transcription intermediary factor 1gamma decreases protein expression of the transcriptional cofactor, LIM-domain-binding 1. in Biochemical and biophysical research communications 2010
Show all 5 references for ABIN953152
Chicken Polyclonal LIM Domain Binding 1 Protein Primary Antibody for WB - ABIN2780230
Marini, Bongers, Cusano, Di Duca, Seri, Knoers, Ravazzolo: Confirmation of CLIM2/LMX1B interaction by yeast two-hybrid screening and analysis of its involvement in nail-patella syndrome. in International journal of molecular medicine 2003
The functional cloning, expression pattern, overexpression, and knockdown data show that an ldb1-regulated mechanism acts as an early signal for Xenopus lens induction.
CLIM interacts with estrogen receptor alpha (show ESR1 Antibodies) at the H19 (show NCKAP1 Antibodies) locus, potentially explaining the higher expression of H19 (show NCKAP1 Antibodies) in female than male corneas.
SSBP3 (show SSBP3 Antibodies) Interacts With Islet-1 (show ISL1 Antibodies) and Ldb1 to Impact Pancreatic beta-Cell Target Genes
the Isl1 (show ISL1 Antibodies)/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
results indicate that LDB1-dependent looping events can deliver repressive cargo to cognate promoters to mediate promoter pausing events in a pituitary cell type
Expression pattern of Isl1 (show ISL1 Antibodies) and its co-factor Ldb1, were analyzed in small intestine.
Data suggest that the function of LIM domain binding protein 1 (LDB1) in the neural crest-derived palatal mesenchyme is essential for normal morphogenesis of the secondary palate.
the LDB1 dimerization domain (DD) is necessary and, when fused to LMO2 (show LMO2 Antibodies), sufficient to completely restore LCR-promoter looping and transcription in LDB1-depleted cells
Ldb1 plays an essential role as a transcription co-regulator of Lhx6 (show LHX6 Antibodies) and Lhx8 (show LHX8 Antibodies) in the control of mammalian telencephalon development.
These results provide a foundation for defining the mechanism and scope of Ldb1 complex activity during erythropoiesis.
Data indicte that the regulation of essential developmental factors by Ldb1 defines it as an upstream transcriptional regulator of hematopoietic/endothelial development.
Alanine scanning mutagenesis of the LIM (show PDLIM5 Antibodies) interaction domain of LDB1 revealed a discrete motif, R(320)LITR, required for LMO2 (show LMO2 Antibodies) binding.
Clim2, in a complex with LMO4 (show LMO4 Antibodies), supports mammary stem cells by directly targeting the Fgfr2 (show FGFR2 Antibodies) promoter in basal cells to increase its expression
In t(8;21) leukemia cells, LDB1 functions as a component of the stable AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin (show HBB Antibodies) locus in human erythroid cells.
These studies are consistent with a model in which TIF1gamma (show TRIM33 Antibodies) acts to ubiquitinate LDB1 leading to degradation of LDB1 and changes in transcription of LDB1-dependent promoters.
Expression of LDB1 (LIM-domain-binding 1) protein in which Lys134 is replaced with arginine leads to enhanced expression of the mutant protein compared with the wild-type protein.
1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4 (show LMO4 Antibodies):ldb1 complex
Ssdp (show SSBP3 Antibodies) proteins interact with the LIM (show PDLIM5 Antibodies)-domain-binding protein Ldb1 to regulate development
characterize the assembly of a five-component complex containing TAL1 (show TAL1 Antibodies), LMO2 (show LMO2 Antibodies), Ldb1, E12 (show ELSPBP1 Antibodies), and DNA. The bHLH domains of TAL1 (show TAL1 Antibodies) and E12 (show ELSPBP1 Antibodies) alone primarily formed helical homodimers, but together formed heterodimers, to which LMO2 (show LMO2 Antibodies) bound with high affinity
Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity.
Study identifies a number of novel Ldb1 interacting proteins in murine erythroleukaemic cells, namely Eto-2 (show CBFA2T3 Antibodies), the cyclin-dependent kinase (show CDK1 Antibodies) Cdk9 (show CDK9 Antibodies), Lmo4 (show LMO4 Antibodies); morphilino-mediated knockdowns in zebrafish show these factors to be essential for haematopoiesis.
Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
, LIM domain-binding factor CLIM2
, LIM domain-binding protein 1
, carboxyl-terminal LIM domain-binding protein 2
, nuclear LIM interactor
, neural Src-interacting protein
, neural src interacting protein
, LIM domain-binding factor-1
, carboxy terminal LIM domain protein 2
, LIM-domain binding factor 1