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LIM Domain Binding 3 Proteins (LDB3)

LDB3 encodes a PDZ domain-containing protein. Additionally we are shipping LIM Domain Binding 3 Protein Antibodies (59) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LDB3 11155 O75112
LDB3 24131 Q9JKS4
Rat LDB3 LDB3 498587  
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Top LIM Domain Binding 3 Protein Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

LDB3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for LIM Domain Binding 3 (LDB3) Interaction Partners

Human LIM Domain Binding 3 (LDB3) interaction partners

  1. this is the first family with Arrhythmogenic right ventricular cardiomyopathy where a mutation in LDB3 is associated with Arrhythmogenic right ventricular cardiomyopathy

  2. Study identified abnormal inclusion of LDB3 exon 11 specific to myotonic dystrophy type at the RNA and protein level; inclusion changed the affinity of LDB3 for PKC, indicating that exon 11 may contribute to the activation of PKC in DM1

  3. results show that MFM-associated ZASP mutations in the actin-binding domain have deleterious effects on the core structure of the Z-discs in skeletal muscle.

  4. Z-band alternatively spliced PDZ motif protein (ZASP) is the major O-linked beta-N-acetylglucosamine-substituted protein in human heart myofibrils

  5. This results of this indicted that One patient harbored the missense mutation c.1719G>A (p.V566M) in the ZASP gene.

  6. ZASP1 can form protein complex with telethonin/T-Cap (show TCAP Proteins) and Na(v)1.5. The left ventricular noncompaction-specific ZASP1 mutation can cause loss of function of Na(v)1.5, without significant alteration of the cytoskeletal protein (show ACTN1 Proteins) complex.

  7. TNNT3 and LDB3 showed abnormal splicing and appeared more pronounced in myotonic dystrophies type 2 relative to myotonic dystrophies type 1.

  8. the D626N mutation of Cypher/ZASP increases the affinity of the LIM (show PDLIM5 Proteins) domain for protein kinase C, which may be related to pathogenesis of dilated cardiomyopathy

  9. ZASP/Cypher internal fragments containing either ZM exon 4 or 6 co-localized with alpha-actinin (show ACTN1 Proteins) in cultured myoblasts and nonmuscle cells.

  10. ZASP/Cypher anchors PGM1 (show PGM1 Proteins) to Z-disc under conditions of stress. The impaired binding of PGM1 (show PGM1 Proteins) to ZASP/Cypher might be involved in the pathogenesis of dilated cardiomyopathy.

Mouse (Murine) LIM Domain Binding 3 (LDB3) interaction partners

  1. Cypher and ENH (show PDLIM5 Proteins) redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability.

  2. results show that MFM-associated ZASP mutations in the actin-binding domain have deleterious effects on the core structure of the Z-discs in skeletal muscle.

  3. Results indicte that Cypher/ZASP interacted with the regulatory subunit RIIalpha of PKA.

  4. Data demonstrated that the Z-disk proteins, ZASP, titin (show TTN Proteins) and vinculin (show VCL Proteins) preferentially bind to alpha-actinin-2 (show ACTN2 Proteins).

  5. Deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy.

  6. mutations of a structural/cytoskeletal protein (show ADD3 Proteins), such as ZASP, lead to cardiac functional and electric abnormalities.

  7. Cypher isoforms are developmentally regulated in both skeletal and cardiac muscle

  8. Cypher plays a pivotal role in adult cardiac structure and function through protein-protein interactions with other Z-line proteins.

LIM Domain Binding 3 Protein (LDB3) Protein Profile

Protein Summary

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified\; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.

Gene names and symbols associated with LIM Domain Binding 3 Proteins (LDB3)

  • LIM domain binding 3b (ldb3b)
  • LIM domain binding 3 (ldb3)
  • LIM domain binding 3 (LDB3)
  • LIM domain binding 3 (LOC100348927)
  • LIM domain binding 3 (Ldb3)
  • AW742271 protein
  • CMD1C protein
  • CYPHER protein
  • LDB3 protein
  • ldb3l protein
  • LDB3Z1 protein
  • LDB3Z4 protein
  • LVNC3 protein
  • MFM4 protein
  • MGC52706 protein
  • MGC75668 protein
  • ORACLE protein
  • PDLIM6 protein
  • RGD1564875 protein
  • wu:fi31d08 protein
  • ZASP protein
  • zgc:55814 protein

Protein level used designations for LIM Domain Binding 3 Proteins (LDB3)

LIM domain binding 3 , LIM domain binding 3 like , LIM domain-binding protein 3 , PDZ and LIM domain 6 , Z-band alternatively spliced PDZ-motif protein , protein cypher , PDZ-LIM domain protein , cypher , oracle protein , protein oracle

GENE ID SPECIES
334100 Danio rerio
379929 Xenopus laevis
394699 Xenopus (Silurana) tropicalis
697140 Macaca mulatta
100348927 Oryctolagus cuniculus
100582910 Nomascus leucogenys
11155 Homo sapiens
536781 Bos taurus
24131 Mus musculus
498587 Rattus norvegicus
479269 Canis lupus familiaris
100151883 Sus scrofa
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