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LMO1 encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family.
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Data suggest that environment pollutants methylmercury and 1-methyl-4-phenylpyridinium decrease release of dopamine from dopaminergic neurons; this mechanism involves down-regulation of expression of Slc6a3 (show SLC6A3 Antibodies).
This study show that Dopamine transporter is enriched in filopodia and induces filopodia formation.
The sigma-1R deficiency through suppressing NR2B (show GRIN2B Antibodies) function and DAT (show SLC6A3 Antibodies) expression can reduce MPTP (show PTPN2 Antibodies)-induced death of dopaminergic neurons and parkinsonism.
DAT (show SLC6A3 Antibodies) gene knockout in mice results dendritic spine loss in pyramidal neurons in the CA1 (show CA1 Antibodies) field of the hippocampus.
Results show that moderate increases in DAT (show SLC6A3 Antibodies) function cause spontaneous dopaminergic cell loss, oxidative stress and fine motor impairment that is reversed by l-DOPA treatment
Chronic and acute reductions of DAT (show SLC6A3 Antibodies) functioning in mice impaired decision-making.
These results demonstrate that the presence of the N-terminal tag leads to impaired DAT (show SLC6A3 Antibodies) protein expression in vivo due in part to improper trafficking of the tagged transporter.
studies demonstrate an in vivo functional impact of the DAT (show SLC6A3 Antibodies) Val559 variant, providing support for the ability of DAT (show SLC6A3 Antibodies) dysfunction to impact risk for mental illness.
The data of this study imply that individual differences in DAT (show SLC6A3 Antibodies) expression (either genetically or pharmacologically induced) may affect susceptibility to addiction of different types of psychostimulants.
findings support the idea that altered DAT (show SLC6A3 Antibodies) and VMAT2 (show Slc18a2 Antibodies) expression affect age-related changes in dopaminergic function.
Study failed to observe a significant association of the SLC6A3 (show SLC6A3 Antibodies) 40-base pair variable number of tandem repeats polymorphism (rs28363170) with cognitive function in healthy adults
the 3'-UTR (show UTS2R Antibodies) VNTR polymorphism is significantly associated with smoking cessation, and smokers with one or more 9-repeat alleles have a 17% higher probability of smoking cessation than smokers carrying no such allele. [meta-analysis]
high SLC6A3 (show SLC6A3 Antibodies) expression in Clear cell renal cell carcinoma (show MOK Antibodies) tissue was correlated with a shorter period of recurrence-free survival following surgery.
Children without the haplotypes associated with the reduced SLC6A3 (show SLC6A3 Antibodies) gene expression and thus lower dopamine functioning appeared to demonstrate altered levels of effortful control as a function of maternal parenting quality.
Computational study providse novel insights into the role of collective dynamics in functionally relevant state-to-state transitions in DAT (show SLC6A3 Antibodies), at a level of atomistic detail
Higher levels of maternal depressive symptoms predicted reduced cortisol flexibility across challenges for infants with at least one A1 allele of DRD2 (show DRD2 Antibodies) and infants with the 10/10 genotype of SLC6A3 (show SLC6A3 Antibodies)
3'-UTR (show UTS2R Antibodies) variable number tandem repeat associated with post-traumatic stress disorder [meta-analysis]
The NET and DAT (show SLC6A3 Antibodies) N Termini Are Critical for Internalization and Postendocytic Sorting.
the putative involvement of DAT1 and DRD4 (show DRD4 Antibodies) genes in the aetiology of Attention-deficit hyperactivity disorder with a main role in modulation of key dimensions of the disorder
we did not find any significant associations of COMT (show COMT Antibodies) or SLC6A3 (show SLC6A3 Antibodies) with inhibitory performance or impulsivity
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
LIM domain only protein 3
, LIM domain only 3
, neuronal-specific transcription factor DAT1
, dopamine-inducible LIM-domain transcription factor DAT1
, DA transporter
, dopamine transporter 1
, sodium-dependent dopamine transporter
, solute carrier family 6 member 3
, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
, solute carrier family 6, member 3