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LIM Domain Only 2 (Rhombotin-Like 1) Proteins (LMO2)

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. Additionally we are shipping LMO2 Antibodies (99) and LMO2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LMO2 16909 P25801
Rat LMO2 LMO2 362176  
LMO2 4005 P25791
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Top LMO2 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,355.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,355.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,355.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,357.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

LMO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) Interaction Partners

Mouse (Murine) LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) interaction partners

  1. Hhex (show HHEX Proteins) regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.

  2. HHEX (show HHEX Proteins) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.

  3. GATA2 (show GATA2 Proteins) and Lmo2 cooperatively regulate VEGF (show VEGFA Proteins)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Proteins).

  4. a regulatory hierarchy of HOX (show MSH2 Proteins) control of LMO2 in normal development

  5. Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.

  6. A model in which the distal control region functions through a chromatin looping mechanism to contact and enhance Lmo2 transcription specifically in erythroid cells.

  7. Studied the solution structure of Lmo2(LIM2 (show LHX2 Proteins)) /Ldb1 (show LDB1 Proteins)(LID) complex. Results show modular binding of tandem LIM (show PDLIM5 Proteins) domains in Lmo2 to tandem linear motifs in Ldb1 (show LDB1 Proteins) is accompanied by several disorder-to-order transitions/ conformational changes in both proteins.

  8. Studies demonstrate that Etv2 (show ETV2 Proteins) is expressed during and required for yolk sac (show ADCY10 Proteins) hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2 (show ETV2 Proteins).

  9. This result raises the possibility that oncogenic Lck (show LCK Proteins) may activate Lmo2 promoter through direct interaction.

  10. Data show that thymic expression of the Tal1 (show TAL1 Proteins) and Lmo2 oncogenes results in rapid development of T-ALL, and similar to T-ALL patients, more than half the leukemic mice develop spontaneous mutations in Notch1 (show NOTCH1 Proteins).

Human LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) interaction partners

  1. that suppression of MIR223 expression, as compared with controls, is associated with lack of differentiation and adverse cytogenetic profile, but unrelated with LMO2 protein expression or overall survival.

  2. Alanine scanning mutagenesis of the LIM (show PDLIM5 Proteins) interaction domain of LDB1 (show LDB1 Proteins) revealed a discrete motif, R(320)LITR, required for LMO2 binding.

  3. LMO2 expression was elevated in GBM tissues and inversely correlated with prognosis of GBM patients. Taken together, our findings describe novel dual roles of LMO2 to induce tumorigenesis and angiogenesis.

  4. Diagnostic Utility of the Germinal Center-associated Markers GCET1 (show SERPINA9 Proteins), HGAL (show GCET2 Proteins), and LMO2 in Hematolymphoid Neoplasms.

  5. Data show that the Lim domain only 2 (LMO2) regulatory element (element-25) region consists of transcription factor GATA2 (show GATA2 Proteins)-binding myeloid ennhancer and RUNX protein-binding T-cell repressor.

  6. Cryptic chromosomal rearrangements in the LMO2 gene were associated with T-cell acute lymphoblastic leukemia.

  7. results suggest that E47 (show TCF3 Proteins) has diverse effects in T-ALL but that functional deficiency of E47 (show TCF3 Proteins) is not a universal feature of Lmo2-induced T-ALL.

  8. HHEX (show HHEX Proteins) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.

  9. LMO2 is expressed in a subset of acute myeloid leukaemia patients and is associated with normal karyotype, which is different from T lymphoblastic lymphoma/leukaemia, where specific translocation (11p13) mediates protein expression.

  10. GATA2 (show GATA2 Proteins) and Lmo2 cooperatively regulate VEGF (show VEGFA Proteins)-induced angiogenesis and lymphangiogenesis via NRP2 (show NELL2 Proteins).

Zebrafish LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) interaction partners

  1. a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure

  2. in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1 (show TAL1 Proteins)-Lmo2-induced haemangioblasts differentiate into endothelial cells

  3. Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated.

  4. Scl (show TAL1 Proteins)/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other

LMO2 Protein Profile

Protein Summary

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with LMO2

  • Rhombotin-2 (rbtn2)
  • LIM domain only 2 (rhombotin-like 1) (LOC100232598)
  • LIM domain only 2 (Lmo2)
  • LIM domain only 2 (rhombotin-like 1) (LMO2)
  • LIM domain only 2 (rhombotin-like 1) (lmo2)
  • LMO-2 protein
  • lmo2-A protein
  • Rbtn-2 protein
  • RBTN2 protein
  • RBTNL1 protein
  • Rhom-2 protein
  • RHOM2 protein
  • rhombotin-2 protein
  • TTG2 protein
  • wu:fc83a08 protein
  • xlmo2 protein
  • zgc:111930 protein

Protein level used designations for LMO2

Rhombotin-2 , LIM domain only 2 (rhombotin-like 1) , LIM domain only protein 2 , LIM only 2 , LMO-2 , T-cell translocation protein 2 , cysteine-rich protein TTG-2 , rhombotin-2 , T-cell translocation gene 2 , rhombotin 2 , rhombotin-like 1 , LIM domain only-2 , ttg2 , zlmo2 , xLMO-2

GENE ID SPECIES
100194984 Salmo salar
100232598 Taeniopygia guttata
100301679 Oncorhynchus mykiss
16909 Mus musculus
362176 Rattus norvegicus
4005 Homo sapiens
30332 Danio rerio
614876 Bos taurus
394388 Xenopus laevis
374129 Gallus gallus
609006 Canis lupus familiaris
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