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LMX1B encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. Additionally we are shipping LIM Homeobox Transcription Factor 1, beta Proteins (6) and LIM Homeobox Transcription Factor 1, beta Kits (5) and many more products for this protein.
Showing 10 out of 79 products:
Human Polyclonal LMX1B Primary Antibody for EIA, IF - ABIN1450031
Hobert, Westphal: Functions of LIM-homeobox genes. in Trends in genetics : TIG 2000
Show all 4 references for ABIN1450031
Human Polyclonal LMX1B Primary Antibody for IHC (p), WB - ABIN652882
Laguna, Schintu, Nobre, Alvarsson, Volakakis, Jacobsen, Gómez-Galán, Sopova, Joodmardi, Yoshitake, Deng, Kehr, Ericson, Svenningsson, Shupliakov, Perlmann: Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. in Nature neuroscience 2015
Chicken Polyclonal LMX1B Primary Antibody for WB - ABIN2780417
Bongers, Huysmans, Levtchenko, de Rooy, Blickman, Admiraal, Huygen, Cruysberg, Toolens, Prins, Krabbe, Borm, Schoots, van Bokhoven, van Remortele, Hoefsloot, van Kampen, Knoers: Genotype-phenotype studies in nail-patella syndrome show that LMX1B mutation location is involved in the risk of developing nephropathy. in European journal of human genetics : EJHG 2005
Otx2 (show OTX2 Antibodies) critically depends on Lmx1b for the formation of mdDA neurons.
results demonstrate an important role for the intersection of Lmx1b and Hoxb8 (show HOXB8 Antibodies)::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing.
Co-immunoprecipitation experiments show that both wild-type and Icst LMX1B are found in complexes with LIM domain binding protein 1 (LDB1 (show LDB1 Antibodies)), resulting in lower levels of functional LMX1B in Icst heterozygotes than null heterozygotes
We posit that microRNA modulation of the Lmx1b/Wnt (show WNT2 Antibodies) axis in the early midbrain/isthmus could determine midbrain size and allocation of dopamine progenitors.
Cell biological and biophysical experiments with primary podocytes isolated after 1 week of Lmx1b inactivation indicated dysregulation of actin cytoskeleton organization
Lmx1b, a key transcription factor for the specification of 5-HT (show DDC Antibodies) and dopaminergic transmitter phenotypes during embryogenesis, determines some peptide phenotypes in these neurons as well.
Data indicate that tryptophan hydroxylase 2 Tph2 (show TPH2 Antibodies)-/- and LIM homeobox transcription factor 1 beta Lmx1b-/- females displayed a change in sexual preference.
A protein complex was identified containing PSPC1 (show PSPC1 Antibodies), PSF (show Il3 Antibodies) and LMX1B, suggesting the existence of this complex in mesodiencephalic dopaminergic neurons.
Lmx1b genes are associated with skeletal development.
This study demonistrated that Lmx1b promotes a neuronal glutamate (show GRIN1 Antibodies) phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex
38 different LMX1B polymorphisms have been found in 55 families with Nail (show CD244 Antibodies)-Patella Syndrome raising the hypothesis of a genetic heterogeneity.
Lmx1a (show LMX1A Antibodies) and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars (show EPRS Antibodies) compacta and the ventral tegmental area. [Review]
these results reveal a sustained and essential requirement of Lmx1b for the function of midbrain dopamine neurons
A heterozygous microdeletion of the entire LMX1B gene using multiplex ligation-dependent probe amplification (MLPA) in a Chinese family with nail (show CD244 Antibodies) patella syndrome, is reported.
Results demonstrate that loss of function may not be the only way that mutated LMX1b causes haploinsufficiency. Mutated LMX1b may interfere withdownsteam transcription events.
In a large family with the two disorders with two novel frameshift TSC1 (show TSC1 Antibodies) and LMX1B mutations, we describe the phenotypes
LMX1B is a novel oncogene (show RAB1A Antibodies) in ovarian cancer pathogenesis.
this study identified two novel mutations of the LMX1B gene in three unrelated families with autosomaldominant Focal Segmental Glomerulosclerosis and no extrarenal features.
LMX1B is important in regulating type IV collagen (show COL4 Antibodies) gene expression in the GBM of the developing kidney and also has a likely role in regulating additional genes important in podocyte function and maintenance
Data report on the association of LMX1B with autism, though it should be viewed with some caution considering the modest associations we report.
Lmx1b and FoxC have roles in regulating podocin expression in podocytes
lmx1b paralogues may contribute to the generation of diencephalic dopaminergic precursors
Results suggest that zebrafish lmx1b.1 and lmx1b.2 promote the survival of periocular mesenchymal cells that influence multiple signaling events required for proper ocular development.
Imx1b.1 regulation of wnt (show WNT2 Antibodies) proteins, pax8 (show PAX8 Antibodies) and fibroblast growth factor 8 (fgf8 (show FGF8 Antibodies)) maintains cell survival in the isthmocerebellar region
The spontaneous calcium spike activity in the hindbrain of developing Xenopus laevis larvae modulates the specification of serotonergic neurons via regulation of expression of the Lmx1b transcription factor.
We have over-expressed lmx1b mRNA alone or in combination with potential interacting molecules and analysed the effects on embryonic kidney structures.
This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
LIM homeobox transcription factor 1, beta
, LIM homeo box transcription factor 1B
, LIM homeobox transcription factor 1-beta
, LIM/homeobox protein 1.2
, LIM/homeobox protein LMX1B
, LIM homeobox protein
, LIM/homeobox protein 1
, LIM/homeobox protein LMX-1.2
, homeobox protein LMX-1
, homeodomain protein (lmx)
, LIM homeobox transcription factor 1, beta 1
, LIM homeobox protein 1b
, LIM homeobox transcription factor 1-beta.1