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LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. Additionally we are shipping LASP1 Antibodies (112) and LASP1 Kits (11) and many more products for this protein.
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Human LASP1 Protein expressed in Escherichia coli (E. coli) - ABIN1047340
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
Show all 5 Pubmed References
The correlation between LIM (show PDLIM5 Proteins) and SH3 domain-containing protein (show PEX13 Proteins) expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker
LASP-1 contributes to the formation and progression of prostate cancer through a NF-kappaappa B pathway.
LASP-1 may essentially involve in the metastasis and growth of CCA (show FBN2 Proteins) and clinical significance of LASP-1 may reside in function as a biomarker to predict prognosis and as a promising therapeutic strategy for CCA (show FBN2 Proteins) patients by the inhibition of LASP-1 expression
It is a target gene of miR-1.
LASP-1 associated with UHRF1 (show UHRF1 Proteins), G9a (show EHMT2 Proteins), Snail1 (show SNAI1 Proteins) and di- and tri (show VANGL2 Proteins)-methylated histoneH3 in a CXCL12 (show CXCL12 Proteins)-dependent manner based on immunoprecipitation and proximity ligation assays
LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P (show S100P Proteins) via the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.
LASP-1, mediated by miR (show MLXIP Proteins)-203, has crucial functions in the proliferation, migration and invasion of human non-small cell lung cancer
Detecting an affection of migratory processes after LASP-1 silencing, we propose that LASP-1 could impact on metastasis of CC [choriocarcinoma]cells.
Results identified LASP1 as a hitherto unknown protein in melanocytes and as novel partner of dynamin (show DNM1 Proteins) in the physiological process of membrane constriction and melanosome vesicle release.
Our results suggest that LASP-1 mRNA overexpression may be mainly implicated in female hepatocellular carcinoma (HCC (show FAM126A Proteins)) and cirrhotic HCCs (show HCCS Proteins); and that LASP1 may play its role with vimentin (show VIM Proteins) in HCC (show FAM126A Proteins) cells.
Results defined LASP1 as a direct target gene for HIF1alpha (show HIF1A Proteins) upregulation that is critical for metastatic progression of PDAC.
Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
LIM-nebulette (show NEBL Proteins), Lasp-1, and zyxin (show ZYX Proteins) may play an important role in the organization of focal adhesions
Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM (show MMRN1 Proteins) proteins.
Data suggest that there are no functional differences between human and mouse LASP-1.
The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
LIM and SH3 domain protein 1
, LIM and SH3 protein 1
, lasp1 protein
, metastatic lymph node gene 50 protein
, MLN 50
, 40 kDa phosphoprotein
, phosphoprotein Lasp-1