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LUC7L3 encodes a protein with an N-terminal half that contains cysteine\\/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). Additionally we are shipping LUC7-Like 3 (S. Cerevisiae) Kits (18) and LUC7-Like 3 (S. Cerevisiae) Proteins (6) and many more products for this protein.
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Human Polyclonal LUC7L3 Primary Antibody for ELISA, WB - ABIN565669
Zhou, Ou, Cho, Benz, Huang: Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. in Molecular and cellular biology 2008
Show all 2 references for ABIN565669
these results show that angiotensin II and hypoxia, signals common to heart failure, result in increased LUC7L3 and RBM25 (show RBM25 Antibodies) splicing regulators, increased binding of RBM25 (show RBM25 Antibodies) to SCN5A (show SCN5A Antibodies) mRNA, increased SCN5A (show SCN5A Antibodies) splice variant abundances, decreased full-length SCN5A (show SCN5A Antibodies) mRNA and protein, and decreased Na(+) current.
RBM25 (show RBM25 Antibodies)/LUC7L3-mediated abnormal SCN5A (show SCN5A Antibodies) mRNA splicing reduced Na+ channel current 91.1+/-9.3% to a range known to cause sudden death.
These results suggest that cisplatin affects RNA splicing by changing the subnuclear distribution of proteins including cisplatin resistance-associated overexpressed protein (CROP).
Luc7A is a new U1 snRNP (show LSM2 Antibodies)-associated splicing factor (show SLU7 Antibodies).
This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
cisplatin resistance-associated overexpressed protein
, cisplatin resistance-associated-overexpressed protein
, luc7-like protein 3
, Cisplatin resistance-associated overexpressed protein
, CRE-associated protein 1
, cAMP regulatory element-associated protein 1
, cisplatin resistance associated overexpressed protein
, okadaic acid-inducible phosphoprotein OA48-18