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Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Additionally we are shipping LARP6 Proteins (4) and many more products for this protein.
Showing 10 out of 30 products:
Human Polyclonal LARP6 Primary Antibody for IF, WB - ABIN527496
Cai, Fritz, Stefanovic, Stefanovic: Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen. in Journal of molecular biology 2010
Show all 8 references for ABIN527496
Human Polyclonal LARP6 Primary Antibody for EIA, FACS - ABIN953137
Glenn, Wang, Schwartz: Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts. in American journal of physiology. Cell physiology 2009
Show all 3 references for ABIN953137
Human Polyclonal LARP6 Primary Antibody for FACS, IHC (p) - ABIN654784
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Show all 2 references for ABIN654784
Cow (Bovine) Polyclonal LARP6 Primary Antibody for WB - ABIN2779135
Valavanis, Wang, Sun, Vaine, Schwartz: Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta. in Gene 2007
We postulate that collagen mRNAs directly partition to the endoplasmic reticulum membrane prior to synthesis of the signal peptide and that LARP6 and nonmuscle myosin filaments mediate this process.
Data indicate that LA motif protein LARP6 binding to spliced leader RNA (5'SL) of collagen alpha2(I) mRNA is more stable than the binding to 5'SL of alpha1(I) mRNA.
The study presents the structure of the La motif and RRM1 (show RRM1 Antibodies) of human LARP6 uncovering in both cases considerable structural variation in comparison to the equivalent domains in La and revealing an unprecedented fold for the RRM1 (show RRM1 Antibodies).
LARP6 is a critical mediator by which IGF-1 (show IGF1 Antibodies) augments synthesis of collagen type I in vascular smooth muscle
The results demonstrate that the La modules of the human LARP6 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection.
Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 (show ID1 Antibodies) during wound healing.
Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization.
LARP6 has a distinctive bipartite RNA binding domain not found in other members of the La superfamily. LARP6 interacts with the two single-stranded regions of the 5' stem-loop.
Acheron may influence differentiation in part via its control of cell adhesion dynamics.
These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals.
achn plays key roles in the processes of differentiation and self-renewal
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity).
La ribonucleoprotein domain family, member 6
, death-associated LA motif protein
, la-related protein 6