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The protein encoded by LBR belongs to the ERG4/ERG24 family. Additionally we are shipping Lamin B Receptor Antibodies (47) and Lamin B Receptor Proteins (5) and many more products for this protein.
dLBR is not a limiting component of the nuclear architecture in Drosophila cells during the first 2 days of development
Data indicate that the LBR of zebrafish and mammals are both required for correct development of embryos.
LBR targets the membrane precursor vesicles to chromatin by interacting with importin beta (show KPNB1 ELISA Kits) in a LBR phosphorylation-dependent manner during the NE assembly at the end of mitosis
Data indicate that proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (Akt (show AKT1 ELISA Kits)) phosphorylates distinct sites than SRPK1 (show SRPK1 ELISA Kits) protein within the arginine-serine (RS) domain of Lamin B Receptor (LBR).
Lamin B receptor mRNA expression was directly associated with tumor grade in breast cancer patients(grade 1 vs. grade 3 - 0.00 vs. 0.00; p = 0.0479) and Nottingham Prognostic Index (NPI1 (show KPNA1 ELISA Kits) vs. NPI3 - 0.00 vs. 0.00; p = 0.0551).
Mutation in LBR gene is associated with pelger-huet anomaly and a mild skeletal phenotype.
Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation.
LBR missense mutations can abolish sterol reductase activity, causing lethal Greenberg dysplasia but not Pelger anomaly
The LBR knockdown cells retain an ovoid shaped nucleus with reduced levels of lamin A/C (show LMNA ELISA Kits) during in vitro granulopoiesis induced with retinoic acid.
Our studies reveal for the first time a mechanism that controls the timing of nuclear envelope reassembly through modification of the integral nuclear membrane protein lamin B receptor
LBR is heavily expressed in papillary thyroid carcinoma cells, but an abnormal folding of the protein might explain its lack of immunohistochemical reactivity and be associated with the anomalous folding of the nuclear membrane.
LBR mutant variants and sterol reductases can severely interfere with the regular organization of the nuclear envelope and the endoplasmic reticulum.
These results show a moderate skin differentiation phenotype, which indicates that upregulation of LBR is not the sole contributor to the Hutchinson-Gilford progeria syndrome phenotype.
The N-terminal portion of LBR is probably responsible for the binding to HP1b (show CBX1 ELISA Kits).
Study identified LBR- and lamin-A/C (show LMNA ELISA Kits)-dependent mechanisms tethering heterochromatin to the nuclear envelope. The two tethers are sequentially used during cellular differentiation and development: first the LBR- and then the lamin-A/C (show LMNA ELISA Kits)-dependent tether.
LBR deficiency affects not only nuclear architecture but also proliferation, cell viability, and gene expression of hematopoietic cells
sterol Delta(14) reductase domain of LBR plays a critical role in cholesterol biosynthesis and that this process is essential to both myeloid cell growth and functional maturation.
Lbr, under transcriptional regulation of C/EBPepsilon (show CEBPE ELISA Kits), is necessary for morphological but not necessarily functional granulocyte maturation.
lamin B receptor, although residing in nuclear membranes, may contribute to cholesterol biosynthesis in Tm7sf2 (show TM7SF2 ELISA Kits)((-/-)) mice
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
, lamin B receptor
, lamin-B receptor
, lamin-B receptor-like
, integral nuclear envelope inner membrane protein
, tudor domain containing 18
, Lamin-B receptor