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Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.. Additionally we are shipping Laminin alpha 1 Antibodies (57) and Laminin alpha 1 Kits (12) and many more products for this protein.
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The distribution of laminin and alphaSMA (show ACTA2 Proteins) in the testis and epididymis might point out to their roles in the male reproduction.
Analysis of zebrafish laminin-alpha 1 mutants reveals multiple functions for laminin-alpha 1 in the outgrowth and guidance of central nervous system axons
Laminin alpha 1 is needed for lens development in zebrafish embryos.
The phenotypic and genetic analyses of a recessive, larval lethal zebrafish mutant, bal(a69), characterized by severe eye defects and shortened body axis, is reported.
two guidance cues, TAG-1 (show CNTN2 Proteins) and laminin-alpha1, influence the behavior of growth cones during axon pathfinding in vivo
tag1 (show CNTN2 Proteins), lama1 and vangl2 (show VANGL2 Proteins) participate in a common mechanism that integrates signaling between the FBMN and its environment to regulate migration.
Our results indicate that invasion of cervical cancer is accomplished by the remodeling of the interstitial stroma, which process includes decrease and partial replacement of fibronectin (show FN1 Proteins) and collagens by a laminin-rich matrix
Novel PMCA3 (show ATP2B3 Proteins) missense mutation co-occurring with a heterozygous mutation in LAMA1 impaired cellular Ca2 (show CA2 Proteins)+ homeostasis in patients with Cerebellar Ataxia (show USP14 Proteins).
Identification of biallelic mutations in LAMA1 as the cause of cerebellar dysplasia with cysts in seven affected individuals.
Studies indicate that progenitor endothelial cells (ECs), endothelial colony-forming cells (ECFCs), deposit collagen IV (show COL4 Proteins), fibronectin (show FN1 Proteins), and laminin.
miR (show MLXIP Proteins)-9 negatively controls lamin A (show LMNA Proteins) and progerin expression in neural cells.
we report associations with the LAMA1 and HMG20A (show HMG20A Proteins) (not previously associated at genome-wide significance in Europeans) gene regions with type 2 diabetes risk
Laminin-alpha1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 (show FOSB Proteins) and NF-kappaB (show NFKB1 Proteins) transcription factors but also has adverse effects.
The polymorphism of SNP rs2089760, located in the promoter region of LAMA1, may be associated with high myopia in the Chinese population.
c-Jun/AP-1 (show JUN Proteins) activity mediated by JNK (show MAPK8 Proteins), PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and ERK (show EPHB2 Proteins) pathways is required for laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells.
Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 (show SDC1 Proteins) and beta1 integrin.
Laminin regulates PDGFRbeta cell differentiation, fate determination, cell stemness and muscle development via gpihbp1 (show GPIHBP1 Proteins).
while MMP-9 (show MMP9 Proteins) is not essential for hypoxic-induced cerebral angiogenesis, it plays an important role in post-hypoxic vascular pruning by degrading laminin and claudin-5 (show CLDN5 Proteins)
interaction of alpha6beta1 in embryonic stem cells (ECCs) with laminin-1 activates alpha6beta1/CD151 (show CD151 Proteins) signaling which programs ESCs (show NR2E3 Proteins) toward the endothelial cells lineage fate
These findings suggest that LAMA1 plays a critical role in kidney function and kidney aging by regulating the mesangial cell population and mesangial matrix deposition through TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling.
Mutations in Lama1 allow developing retinal vessels to enter the vitreous where they anastomose with vessels of the hyaloid system which persist and expand
Our data show that the absence of Lama1 has an impact on the Bergmann glia scaffold that aberrantly develops.
Laminin alpha1 chain is not responsible for muscle disease in the mdx (show DMD Proteins) mouse model for Duchenne muscular dystrophy (show DMD Proteins)
This first report of viable Lama1 mouse mutants emphasizes the importance of this gene in retinal development, and data suggest that hypomorphic mutations in human LAMA1 could lead to retinal disease.
Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 (show MMP9 Proteins) expression.
mouse laminin alpha 1 gene has an upstream enhancer that defines its expression in parietal endoderm cells
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
laminin subunit alpha-1
, laminin, alpha 1
, laminin subunit alpha-1-like
, S-LAM alpha
, S-laminin subunit alpha
, laminin A chain
, laminin-3 subunit alpha
, laminin-1 subunit alpha