Laminin, beta 1 Proteins (LAMB1)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Additionally we are shipping Laminin beta 1 Antibodies (92) and Laminin beta 1 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LAMB1 16777  
Rat LAMB1 LAMB1 298941  
LAMB1 3912 P07942
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Top Laminin beta 1 Proteins at

Showing 8 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
HOST_Escherichia coli (E. coli) Human His tag Laminin, beta 1 (LAMB1) (AA 1533-1782), (partial) protein (His tag) 50 μg Log in to see 13 to 16 Days
HOST_Escherichia coli (E. coli) Human His tag,GST tag 50 μg Log in to see 13 to 16 Days
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
Yeast Hydra His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days

LAMB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
, ,

More Proteins for Laminin, beta 1 (LAMB1) Interaction Partners

Zebrafish Laminin, beta 1 (LAMB1) interaction partners

  1. Transient induction of lamb1a in epithelial cells is a key, growth factor-guided step in formation of a signaling-competent regeneration epidermis.

  2. Data show that lamb1a regulates asymmetric left-right gene expression in the lateral plate mesoderm (LPM).

  3. Two zebrafish loci, grumpy and sleepy (show LAMC1 Proteins), encode laminin beta1 and laminin gamma1, respectively. These genes are required for the formation of the laminin-dependent basement membrane is essential for the differentiation of chordamesoderm to notochord.

Mouse (Murine) Laminin, beta 1 (LAMB1) interaction partners

  1. Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (show NRG1 Proteins) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.

  2. These results suggest the possibility that up-regulation of LAMB1 in podocytes, should it become achievable, would likely lessen the severity of nephrotic syndrome in patients carrying LAMB2 (show LAMB2 Proteins) mutations.

  3. Laminin beta(1) and gamma(1) N-terminal domains share the galactose-binding domain-like fold.

  4. laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD (show DMD Proteins) patient myoblasts

Human Laminin, beta 1 (LAMB1) interaction partners

  1. LAMB1 may affect the initiation and progression of pneumoconiosis, or serve as a potential biomarker of pneumoconiosis for diagnosis and genetic susceptibility.

  2. Our results suggest that an impairment in adhesion exists in vitiligo (show MITF Proteins) skin, which is supported by the diminished immunohistochemical expression of laminin, beta1 integrin, ICAM-1 (show ICAM1 Proteins) and VCAM-1 (show VCAM1 Proteins).

  3. LAMB1 is a potential serological biomarker that could be used in conjunction with carcinoembryonic antigen (show CEACAM5 Proteins) for diagnosis of colorectal cancer.

  4. These results suggest that MUC5B production can be regulated by ECM (show MMRN1 Proteins) components and that MUC5B is upregulated by fibronectin (show FN1 Proteins) and laminin via the integrin, ERK (show EPHB2 Proteins), and NF-kappaB (show NFKB1 Proteins) dependent pathway.

  5. An association was found between LAMB1 rs2158836 polymorphisms and symptom severity in Korean autism spectrum disorder patients.

  6. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146 (show MCAM Proteins)).

  7. LAMB1 single nucleotide polymorphism rs886774 was associated with early onset Ulcerative colitis and, thus, suggests a fundamentally different mechanism of early disease pathogenesis in Ulcerative colitis versus Crohn's disease.

  8. Upregulation of LAMB1 expression was highly correlated with the downregulation of miR (show MLXIP Proteins)-124-5p. LAMB1 protein expression was suppressed by miR (show MLXIP Proteins)-124-5p.

  9. The phenotype due to LAMB2 (show LAMB2 Proteins) mutations appears to be similar between different ethnic groups.

  10. Homozygous deleterious mutations in LAMB1.

Laminin beta 1 (LAMB1) Protein Profile

Protein Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Gene names and symbols associated with Laminin, beta 1 Proteins (LAMB1)

  • laminin, beta 1 (LAMB1)
  • laminin, beta 1a (lamb1a)
  • laminin, beta 2 (laminin S) (lamb2)
  • laminin, beta 1 (lamb1)
  • laminin B1 (Lamb1)
  • laminin, beta 1 (Lamb1)
  • C77966 protein
  • C80098 protein
  • C81607 protein
  • CLM protein
  • D130003D08Rik protein
  • fc20b05 protein
  • gup protein
  • Lamb-1 protein
  • LAMB1 protein
  • Lamb1-1 protein
  • lams protein
  • LIS5 protein
  • sb:cb95 protein
  • wu:fc20b05 protein

Protein level used designations for Laminin, beta 1 Proteins (LAMB1)

cb95 , grumpy , laminin subunit beta-1 , laminin, beta 1 , laminin beta-1 chain , laminin beta 2 , laminin subunit beta-1-like , laminin B1 chain , laminin B1 subunit 1 , laminin-1 subunit beta , laminin-10 subunit beta , laminin-12 subunit beta , laminin-2 subunit beta , laminin-6 subunit beta , laminin-8 subunit beta , laminin B1 , laminin beta-1-1 chain

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16777 Mus musculus
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3912 Homo sapiens
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520030 Bos taurus
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