Laminin, gamma 2 Proteins (LAMC2)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Additionally we are shipping LAMC2 Antibodies (56) and LAMC2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LAMC2 3918 Q13753
LAMC2 16782  
LAMC2 192362  
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Top LAMC2 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$560.00
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$698.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$688.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$756.25
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$893.75
Details

LAMC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine) ,
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Rat (Rattus)

More Proteins for Laminin, gamma 2 (LAMC2) Interaction Partners

Human Laminin, gamma 2 (LAMC2) interaction partners

  1. Overexpression of LAMC2 and knockdown of CD82 (show CD82 Proteins) markedly promoted GC cell invasion and activated EGFR (show EGFR Proteins)/ERK1/2-MMP7 (show MMP7 Proteins) signaling via upregulation of the expression of phosphorylated (p)-EGFR (show EGFR Proteins), p-ERK1/2 and MMP7 (show MMP7 Proteins).

  2. The data presented provide a novel insight into how CDX2 (show CDX2 Proteins) is implicated in the transcriptional regulation of LAMC2 in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha (show TNF Proteins) is present.

  3. Seventeen percent of the patients were compound heterozygous or homozygous for mutations in the gene LAMA3 (show LAMA3 Proteins), 59% carried mutations in both alleles of LAMB3 (show LAMB3 Proteins), and 12% were homozygous for mutations in LAMC2. In nine patients with severe generalized JEB, detection of two mutations in one of the genes LAMA3 (show LAMA3 Proteins), LAMB3 (show LAMB3 Proteins), or LAMC2 was not possible, so the molecular basis of disease could not be clarified completely

  4. Laminin expression depends on Ecad (show CDH1 Proteins) loss and allows Ecad (show CDH1 Proteins)-defective gastric cancer cells to survive and invade.

  5. Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT (show ITK Proteins) and may be a potential therapeutic target.

  6. LAMC2 is a novel non-small cell lung cancer prognostic factor.

  7. Diagnostic value of p40 (show IL9 Proteins) and LN332 in metaplastic spindle cell carcinoma of the breast was found to be less than that of routinely used markers (p63 (show RPE65 Proteins) and cytokeratins). LN332 showed staining in a significant proportion of phyllodes tumours and sarcomas.

  8. The elevated expression of LAMC2 on cancer cells appears to drive tumorigenesis through its interactions with several cell-surface receptors

  9. Molecular expression of MMP-7 (show MMP7 Proteins), laminin c2 or EGFR (show EGFR Proteins), and their combinations, may be associated with gastric cancer tumor aggressiveness

  10. Through an unbiased genetic approach involving a combination of QTL mapping and positional cloning, we demonstrate that Col17a1 (show COL17A1 Proteins) is a strong genetic modifier of the non-Herlitz JEB that develops in Lamc2(jeb) mice

Mouse (Murine) Laminin, gamma 2 (LAMC2) interaction partners

  1. Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT (show ITK Proteins) and may be a potential therapeutic target.

  2. Periostin (show POSTN Proteins) was associated with laminin gamma2, and this association enhanced the proteolytic cleavage of the laminin gamma2 long form to produce its short form.

  3. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1 (show NID1 Proteins), fibulin-1 (show FBLN1 Proteins) and fibulin-2 (show FBLN2 Proteins)

  4. Thymosin beta(4 (show TMSB4X Proteins)) stimulates Lamc2 production independent of TGF-beta (show TGFB1 Proteins).

  5. agrin (show AGRN Proteins) and perlecan (show HSPG2 Proteins) cluster with laminin-2 to contribute to assembly of aneural AChR clusters that precede neural agrin (show AGRN Proteins) release as well as affect later NMJ development

  6. Protein production was in excess (show RCC1 Proteins) of the amount required to form heterotrimeric laminin-332 and was associated with the migrating epithelial sheet, suggesting a potential role in wound healing for monomeric laminin-gamma2.

  7. Laminin gamma2 mediates Wnt5a (show WNT5A Proteins)-induced invasion of gastric cancer cells.

LAMC2 Protein Profile

Protein Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain\; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.

Gene names and symbols associated with Laminin, gamma 2 Proteins (LAMC2)

  • laminin subunit gamma 2 (LAMC2)
  • laminin, gamma 2 (Lamc2)
  • laminin subunit gamma 2 (Lamc2)
  • AA589349 protein
  • B2T protein
  • BM600 protein
  • CSF protein
  • EBR2 protein
  • EBR2A protein
  • LAMB2T protein
  • LAMC2 protein
  • LAMNB2 protein

Protein level used designations for Laminin, gamma 2 Proteins (LAMC2)

laminin 5 gamma 2 subunit , laminin subunit gamma-2 , laminin-5 gamma 2 , laminin, gamma 2 , laminin, gamma 2-like , laminin 5 gamma 2 , BM600-100kDa , CSF 140 kDa subunit , cell-scattering factor 140 kDa subunit , epiligrin subunit gamma , kalinin subunit gamma , ladsin 140 kDa subunit , laminin B2t chain , large adhesive scatter factor 140 kDa subunit , nicein subunit gamma , kalinin/nicein/epiligrin 100 kDa subunit , laminin gamma2 chain , laminin-5 subunit gamma , nicein, 100kD , nicein, 100kDa , lamimin, gamma 2

GENE ID SPECIES
408043 Gallus gallus
442939 Canis lupus familiaris
457571 Pan troglodytes
511043 Bos taurus
715212 Macaca mulatta
100216328 Ovis aries
3918 Homo sapiens
16782 Mus musculus
791245 Equus caballus
192362 Rattus norvegicus
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