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Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Additionally we are shipping Large Neutral Amino Acid Transporter 3 Antibodies (7) and and many more products for this protein.
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Results suggest that leukemia cell proliferation can be significantly suppressed by blocking amino acid transporter LAT3.
Inhibition of LAT (show ORC3 Proteins) transporters may provide a novel therapeutic target in metastatic castration-resistant prostate cancer, via suppression of mammalian target of rapamycin (show FRAP1 Proteins) complex 1 activity and M-phase cell cycle genes.
Data show that signaling via the androgen receptor and ATF4 pathways regulates expression of the amino acid transporters LAT1 and LAT3, thereby coordinating their increased expression in prostate cancer cells.
LAT3 may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton.
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
Y+L amino acid transporter 2
, amino acid permease
, cationic amino acid transporter, y+ system
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
, solute carrier family 7 member 6
, y(+)L-type amino acid transporter 2