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Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. Additionally we are shipping Late Endosomal/lysosomal Adaptor, MAPK and MTOR Activator 1 Proteins (6) and Late Endosomal/lysosomal Adaptor, MAPK and MTOR Activator 1 Kits (3) and many more products for this protein.
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Human Polyclonal LAMTOR1 Primary Antibody for ICC, IF - ABIN4285975
Taub, Nairz, Hilber, Hess, Weiss, Huber: The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. in Journal of cell science 2012
Show all 4 references for ABIN4285975
Data suggest that ablation of p18/LAMTOR1 suppresses starvation-induced cell death by stimulating autophagy through modulation of p27(kip1 (show CDKN1B Antibodies)) activity.
LAMTOR1 expression affects the tuning of lysosomal activation that can lead to p53 (show TP53 Antibodies)-dependent apoptosis through excessive catabolism.
A p27(kip1 (show CDKN1B Antibodies))-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA (show RHOA Antibodies) and RhoC (show RHOC Antibodies).
MT1-MMP (show MMP14 Antibodies)-associated protein p27RF-Rho binds p27(kip1 (show CDKN1B Antibodies)) and prevents p27(kip1 (show CDKN1B Antibodies)) from binding to RhoA (show RHOA Antibodies). [p27RF-Rho]
A complex encoded by the MAPKSP1 (show MAPKSP1 Antibodies), ROBLD3 (show LAMTOR2 Antibodies), and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
Studies in rat and mic (show CDKN2C Antibodies)e, identified the rat p18 protein a (show MAP2K1 Antibodies)s an (show EPHB2 Antibodies) endosomal membrane anchoring protein which interacts with MEK1 scaffold (show MAP2K1 Antibodies)p14/ (show EPHB2 Antibodies)MP1 and mobilizes them to late endosome.
Findings suggested that the p18 (show CDKN2C Antibodies)-associated pathways, mTORC1 and/or MAPK (show MAPK1 Antibodies) pathways, are involved in promoting functional interactions between lysosomes and target organelles to regulate lysosome-mediated catabolic processes.
These results suggest that the p18 (show CDKN2C Antibodies)-mTORC1 pathway plays crucial roles in the late stages of lysosomal maturation, potentially in late endosome-lysosome fusion, which is required for processing of various macromolecules.
analysis of interactions between kinase scaffold MP1 (show MAPKSP1 Antibodies)/p14 (show PCOLCE Antibodies) and its endosomal anchoring protein p18 (show CDKN2C Antibodies)
lipid raft adaptor p18 (show CDKN2C Antibodies) is essential for anchoring the MEK (show MDK Antibodies)-ERK (show EPHB2 Antibodies) pathway to late endosomes, and shed new light on a role of endosomal MEK (show MDK Antibodies)-ERK (show EPHB2 Antibodies) pathway in controlling endosome dynamics.
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity).
late endosomal/lysosomal adaptor and MAPK and MTOR activator 1
, p27Kip1-releasing factor from RhoA
, ragulator complex protein LAMTOR1
, rhoA activator C11orf59 homolog
, RhoA activator C11orf59
, lipid raft adaptor protein p18
, p27kip1 releasing factor from RhoA
, protein associated with DRMs and endosomes
, ragulator complex protein PDRO
, RhoA activator C11orf59 homolog