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The protein encoded by LTBP2 belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. Additionally we are shipping LTBP2 Kits (12) and LTBP2 Proteins (2) and many more products for this protein.
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LTBP-2 and FGF-2 (show FGF2 Antibodies) are co-localized in fibrotic human keloid and hypertrophic scar.
LTBP-2 is a potent inhibitor of FGF-2 (show FGF2 Antibodies) that may influence FGF-2 (show FGF2 Antibodies) bioactivity during wound repair particularly in fibrotic tissues.
LTBP2 was able to reduce phosphorylation of p65 (show GORASP1 Antibodies) at Serine 536, inhibit nuclear localization of active phosphorylated p65 (show GORASP1 Antibodies), and impair the p65 (show GORASP1 Antibodies) DNA-binding ability. This results in a consequential down-regulation of p65 (show GORASP1 Antibodies)-related gene expression.
LTBP-2 is an essential component for the formation of microfibril bundles in ciliary zonules.
perlecan (show HSPG2 Antibodies) HS was not essential for latent transforming growth factor-beta-1 (show TGFB1 Antibodies) binding protein-2 deposition
Overall the results indicate that LTBP-2 may have a negative regulatory role during elastic fiber assembly, perhaps in displacing elastin (show ELN Antibodies) microassemblies from complexes with fibulin-5 (show FBLN5 Antibodies) and/or cell surface heparan sulfate proteoglycans.
Increased plasma levels of LTBP2 and/or OPN (show SPP1 Antibodies) are present in plasma up to 2 years prior to diagnosis of hepatocellular carcinoma.
Some LTBP2 sequence variations can contribute to the etiology of primary open angle glaucoma (POAG) and pseudoexfoliation (PEX (show PHEX Antibodies)) glaucoma syndrome.
No pathogenic variants are identified in the LTBP2 gene in a cohort of patients with primary congenital glaucoma.
LTBP2 mutations were not found in the Turkish GLC3C-linked primary congenital glaucoma (PCG) family or in 94 British CYP1B1 (show CYP1B1 Antibodies)-negative PCG cases.
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5 (show PCSK5 Antibodies)/6A.
These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers.
This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta (show TGFB1 Antibodies) binding proteins affecting TGFbeta (show TGFB1 Antibodies) bioavailability in the ovary.
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.
latent transforming growth factor beta binding protein 2
, latent transforming growth factor beta binding protein 3
, latent transforming growth factor-beta binding protein 3
, latent-transforming growth factor beta-binding protein 2-like
, latent-transforming growth factor beta-binding protein 2
, LTBP-2 like protein
, latent-transforming growth factor beta-binding protein 3