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Latent Transforming Growth Factor beta Binding Protein 3 Proteins (LTBP3)

The protein encoded by LTBP3 forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Additionally we are shipping LTBP3 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat LTBP3 LTBP3 29690  
LTBP3 4054 Q9NS15
LTBP3 16998 Q61810
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Top LTBP3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

LTBP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Latent Transforming Growth Factor beta Binding Protein 3 (LTBP3) Interaction Partners

Zebrafish Latent Transforming Growth Factor beta Binding Protein 3 (LTBP3) interaction partners

  1. Embryos injected with an nkx2.5 morpholino exhibited SHF (show GJA1 Proteins) phenotypes caused by compromised progenitor cell proliferation. Co-injecting low doses of nkx2.5 and ltbp3 morpholinos revealed a genetic interaction between these factors.

  2. a requirement for ltbp3-TGF-beta (show TGFB1 Proteins) signalling during zebrafish SHF (show GJA1 Proteins) development, a process that serves to enlarge the single ventricular chamber in this species

Human Latent Transforming Growth Factor beta Binding Protein 3 (LTBP3) interaction partners

  1. New recessive truncating mutation in LTBP3 (show LTBP2 Proteins) has been described in a family with oligodontia, short stature, and mitral valve prolapse.

  2. Phenotype-genotype correlations between LTBP3 (show LTBP2 Proteins) mutations and families with brachyolmia with amelogenesis imperfecta.

  3. the mechanism of transcriptional activation of LTBP3 (show LTBP2 Proteins) promoter depends on MALAT1 initiated from neighboring gene LTBP3 (show LTBP2 Proteins) and involves both the direct interaction of the Sp1 (show PSG1 Proteins) and promoter-specific activation

  4. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5 (show PCSK5 Proteins)/6A.

  5. These findings indicate that human latent TGF-beta-binding protein-3 (LTBP-3) has an essential role in the secretion and targeting of transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins)).

  6. Extracellular matrix is an important site of deposition for LTBP-3 and LTBP-4.

  7. stimulation of transcriptional activity of promoter is stimulated by TGF-beta 1 (show TGFB1 Proteins)

  8. Data show that LTBP-3 (show LTBP2 Proteins) play an important regulatory role in TGF-beta (show TGFB1 Proteins) activation and autocrine growth control in mesenchymal stem cells.

Mouse (Murine) Latent Transforming Growth Factor beta Binding Protein 3 (LTBP3) interaction partners

  1. Marfan syndrome mice lacking LTBP-3 have improved survival, essentially no aneurysms, reduced disruption and fragmentation of medial elastic fibers, and decreased Smad2/3 and Erk1/2 activation in their aortas.

  2. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5 (show PCSK5 Proteins)/6A.

  3. These data indicate that LTBP-3 and -4 perform partially overlapping functions only in the lungs.

  4. Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability

  5. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-beta (show TGFB1 Proteins) propeptide.

  6. Disruption of Ltbp-3 gene by homologous recombination in mice yields mutant animals displaying multiple skeletal abnormalities and retarded growth. Severe involution of thymus and spleen and reduction in CD4 (show CD4 Proteins)/CD8 (show CD8A Proteins) double positive T-cells in thymus.

  7. Lack of Ltbp-3 results in decreased levels of TGF-beta (show TGFB1 Proteins) in bone and cartilage, which leads to compromised osteoclast function and decreased bone turnover.

  8. Loss of Ltbp-3 is associated with lung alveolar septation and developmental emphysema.

LTBP3 Protein Profile

Protein Summary

The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with LTBP3

  • latent transforming growth factor beta binding protein 3 (Ltpb3)
  • latent transforming growth factor beta binding protein 3 (ltbp3)
  • latent transforming growth factor beta binding protein 3 (LTBP3)
  • latent transforming growth factor beta binding protein 3 (Ltbp3)
  • LTBP-3 protein
  • Ltbp2 protein
  • mFLJ00070 protein
  • pp6425 protein
  • si:ch211-247o20.1 protein
  • STHAG6 protein

Protein level used designations for LTBP3

latent transforming growth factor beta binding protein 3 , latent-transforming growth factor beta-binding protein 3 , latent TGF beta binding protein 3 , LTBP-3

GENE ID SPECIES
29690 Rattus norvegicus
562912 Danio rerio
100559303 Anolis carolinensis
4054 Homo sapiens
16998 Mus musculus
83838 Rattus norvegicus
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