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Latexin Proteins (LXN)

LXN encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. Additionally we are shipping Latexin Antibodies (155) and Latexin Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LXN 56925 Q9BS40
LXN 17035 P70202
LXN 59073 Q64361
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Top Latexin Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 0.1 mg Log in to see 2 to 3 Days
$653.13
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$704.00
Details

LXN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

Top referenced Latexin Proteins

  1. Human Latexin Protein expressed in Human Cells - ABIN2002362 : Aagaard, Listwan, Cowieson, Huber, Ravasi, Wells, Flanagan, Kellie, Hume, Kobe, Martin: An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1. in Structure (London, England : 1993) 2005 (PubMed)
    Show all 3 references for ABIN2002362

  2. Mouse (Murine) Latexin Protein expressed in Escherichia coli (E. coli) - ABIN2007231 : Liu, Yu, Gao, Fu, Zhang, Zhang, Chen, Zhao: Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. in Molecular biology reports 2001 (PubMed)
    Show all 3 references for ABIN2007231

  3. Human Latexin Protein expressed in Escherichia coli (E. coli) - ABIN666749 : de Haan: Latexin is a newly discovered regulator of hematopoietic stem cells. in Nature genetics 2007 (PubMed)
    Show all 2 references for ABIN666749

  4. Human Latexin Protein expressed in Escherichia coli (E. coli) - ABIN2181491 : Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: Initial characterization of the human central proteome. in BMC systems biology 2011 (PubMed)
    Show all 2 references for ABIN2181491

More Proteins for Latexin (LXN) Interaction Partners

Human Latexin (LXN) interaction partners

  1. Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells.

  2. Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells.

  3. latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues.

  4. CD146 (show MCAM Proteins) and Lxn increased tumor migration and invasion of thyroid cancer.

  5. The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma.

  6. These results are consistent with a tumor suppressor role for latexin.

  7. Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines.

Mouse (Murine) Latexin (LXN) interaction partners

  1. Rps3 (show RPS3 Proteins) knockdown increased the radiation sensitivity of FDC-P1, confirming that the mechanism of action of Lxn is mediated by Rps3 (show RPS3 Proteins) pathway.

  2. These results are consistent with a tumor suppressor role for latexin.

  3. Latexin is preferentially expressed in hematopoietic stem cells, and is co-localized with the molecules responsible for the interaction of hematopoietic stem cells with a bone marrow niche.

  4. Data indicate that AAV-mediated latexin transduction or administration of a small molecule carboxypeptidase A inhibitor significantly reduced acetone-evoked nociceptive behavior after SNI.

  5. The crystal structure of mouse latexin, solved at 1.83 A resolution, shows no structural relationship with other carboxypeptidase inhibitors.

  6. Latexin is involved in the transmission of pain, since mice lacking this protein experience reducted pain sensitivity.

  7. promoter polymorphisms between the B6 and D2 alleles may affect Lxn gene expression and consequently influence the population size of hematopoietic stem cells.

  8. These results indicate that latexin is involved in BMP-2 (show BMP2 Proteins)-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration.

Latexin (LXN) Protein Profile

Protein Summary

This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases.

Gene names and symbols associated with Latexin Proteins (LXN)

  • latexin (lxn)
  • latexin (LXN)
  • Latexin (lxn)
  • latexin (LOC100346216)
  • latexin (Lxn)
  • ECI protein
  • lxn protein
  • TCI protein
  • wu:fk66c02 protein
  • zgc:103612 protein

Protein level used designations for Latexin Proteins (LXN)

latexin , Latexin , MUM , endogenous carboxypeptidase inhibitor , tissue carboxypeptidase inhibitor , ECI , TCI

GENE ID SPECIES
494053 Danio rerio
703996 Macaca mulatta
771519 Gallus gallus
100195080 Salmo salar
100322883 Felis catus
100346216 Oryctolagus cuniculus
56925 Homo sapiens
17035 Mus musculus
59073 Rattus norvegicus
610062 Canis lupus familiaris
781644 Bos taurus
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