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LXN encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. Additionally we are shipping Latexin Antibodies (166) and Latexin Proteins (25) and many more products for this protein.
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Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells.
Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells.
latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues.
CD146 (show MCAM ELISA Kits) and Lxn increased tumor migration and invasion of thyroid cancer.
The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma.
These results are consistent with a tumor suppressor role for latexin.
Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines.
By using an Lxn knockout mouse model, this study found that Lxn inactivation in vivo led to the physiological expansion of the entire hematopoietic hierarchy. Loss of Lxn enhanced the competitive repopulation capacity and survival of hematopoietic stem cells in a cell-intrinsic manner.
Rps3 (show RPS3 ELISA Kits) knockdown increased the radiation sensitivity of FDC-P1, confirming that the mechanism of action of Lxn is mediated by Rps3 (show RPS3 ELISA Kits) pathway.
Latexin is preferentially expressed in hematopoietic stem cells, and is co-localized with the molecules responsible for the interaction of hematopoietic stem cells with a bone marrow niche.
Data indicate that AAV-mediated latexin transduction or administration of a small molecule carboxypeptidase A inhibitor significantly reduced acetone-evoked nociceptive behavior after SNI.
The crystal structure of mouse latexin, solved at 1.83 A resolution, shows no structural relationship with other carboxypeptidase inhibitors.
Latexin is involved in the transmission of pain, since mice lacking this protein experience reducted pain sensitivity.
promoter polymorphisms between the B6 and D2 alleles may affect Lxn gene expression and consequently influence the population size of hematopoietic stem cells.
These results indicate that latexin is involved in BMP-2 (show BMP2 ELISA Kits)-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration.
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases.
, endogenous carboxypeptidase inhibitor
, tissue carboxypeptidase inhibitor