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LXN encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. Additionally we are shipping Latexin Antibodies (170) and Latexin Kits (3) and many more products for this protein.
Showing 10 out of 25 products:
Human Latexin Protein expressed in Human Cells - ABIN2002362
Aagaard, Listwan, Cowieson, Huber, Ravasi, Wells, Flanagan, Kellie, Hume, Kobe, Martin: An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1. in Structure (London, England : 1993) 2005
Show all 3 references for ABIN2002362
Human Latexin Protein expressed in Escherichia coli (E. coli) - ABIN2002364
Liu, Yu, Gao, Fu, Zhang, Zhang, Chen, Zhao: Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. in Molecular biology reports 2001
Show all 3 references for ABIN2002364
Mouse (Murine) Latexin Protein expressed in Escherichia coli (E. coli) - ABIN2007231
Pallarès, Bonet, García-Castellanos, Ventura, Avilés, Vendrell, Gomis-Rüth: Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Latexin Protein expressed in Escherichia coli (E. coli) - ABIN666749
de Haan: Latexin is a newly discovered regulator of hematopoietic stem cells. in Nature genetics 2007
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Human Latexin Protein expressed in Escherichia coli (E. coli) - ABIN2181491
Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: Initial characterization of the human central proteome. in BMC systems biology 2011
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Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells.
Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells.
latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues.
CD146 (show MCAM Proteins) and Lxn increased tumor migration and invasion of thyroid cancer.
The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma.
These results are consistent with a tumor suppressor role for latexin.
Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines.
Rps3 (show RPS3 Proteins) knockdown increased the radiation sensitivity of FDC-P1, confirming that the mechanism of action of Lxn is mediated by Rps3 (show RPS3 Proteins) pathway.
Latexin is preferentially expressed in hematopoietic stem cells, and is co-localized with the molecules responsible for the interaction of hematopoietic stem cells with a bone marrow niche.
Data indicate that AAV-mediated latexin transduction or administration of a small molecule carboxypeptidase A inhibitor significantly reduced acetone-evoked nociceptive behavior after SNI.
The crystal structure of mouse latexin, solved at 1.83 A resolution, shows no structural relationship with other carboxypeptidase inhibitors.
Latexin is involved in the transmission of pain, since mice lacking this protein experience reducted pain sensitivity.
promoter polymorphisms between the B6 and D2 alleles may affect Lxn gene expression and consequently influence the population size of hematopoietic stem cells.
These results indicate that latexin is involved in BMP-2 (show BMP2 Proteins)-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration.
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases.
, endogenous carboxypeptidase inhibitor
, tissue carboxypeptidase inhibitor