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anti-Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) Antibodies

The protein encoded by LRAT is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Additionally we are shipping LRAT Proteins (8) and LRAT Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LRAT 9227 O95237
LRAT 79235 Q9JI60
LRAT 64047 Q9JI61
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Top anti-LRAT Antibodies at antibodies-online.com

Showing 10 out of 66 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, using LRAT Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using LRAT Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged LRAT is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of LRAT expression in HEK293T (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunofluorescence analysis of HuvEc cells, using LRAT Antibody . The picture on the right is treated with the synthesized peptide. Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged LRAT is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Mouse Rabbit Un-conjugated IHC, WB   50 μg Log in to see 8 to 10 Days
$991.83
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details

LRAT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-LRAT Antibodies

  1. Human Polyclonal LRAT Primary Antibody for IF, IHC - ABIN1533557 : Mondal, Ruiz, Bok, Rando: Lecithin retinol acyltransferase contains cysteine residues essential for catalysis. in Biochemistry 2000 (PubMed)

  2. Human Monoclonal LRAT Primary Antibody for ELISA - ABIN522683 : Guignard, Jin, Pequignot, Li, Chassigneux, Chekroud, Guillou, Richard, Hamel, Brabet: FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against LRAT Interaction Partners

Human Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. LRAT hypermethylation was associated with decreased mRNA levels in colorectal cancer clinical specimens.

  2. lecithin retinol acyltransferase affects all-trans retinoic acid levels and has a role in retinoid sensitivity in malignant melanoma cells.

  3. These findings reveal structural adaptation that facilitates selective catalysis and mechanism responsible for diverse substrate specificity within the LRAT-like enzyme family

  4. high LRAT expression in melanoma might be important in removing retinol as substrate for RA production, thereby inducing signalling pathways leading to dedifferentiation, proliferation and anti-apoptosis

  5. Functional hepatic stellate cells coexpressing both LRAT and CRBP-1 (show RBP1 Antibodies), that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis.

  6. Lecithin-retinol acyltransferase is a thermostable and highly active enzyme with a likely mode of interfacial activation.

  7. A genetic defect was identified in LRAT as a novel cause of retinitis punctata albescens.

  8. Data show that acyl-modified forms of HRAS (show HRAS Antibodies)-like tumor suppressors HRASLS2 (show HRASLS2 Antibodies) and HRASLS3 (show PLA2G16 Antibodies) mimicking lipolytic activity of lecithin retinol acyltransferase LRAT.

  9. LRAT mutations cause a severe, early childhood onset, progressive retinal dystrophy (show MERTK Antibodies).

  10. This study showed that malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters (RE) into 11-cis (show CISH Antibodies) retinol, whereas their benign counterparts-melanocytes are not able to catalyze these reactions.

Cow (Bovine) Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase.

  2. LRAT is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 (show RPE65 Antibodies) with membranes is neither dependent upon LRAT nor the result of S-palmitoylation

Mouse (Murine) Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. examined LRAT regulatory region is sufficient to achieve strong and selective expression in the eye and testes but not in liver and other organs

  2. LRAT overexpression diminishes intracellular levels of biologically active retinoids and reduces retinoid antitumor efficacy in the murine melanoma

  3. Mislocalized M-opsin was degraded whereas mislocalized S-opsin (show OPN1SW Antibodies) accumulated in Lrat(-/-) cones before the onset of massive ventral/central cone degeneration.

  4. Studies provide mechanistic insights into how vitamin A is distributed to peripheral tissues in a regulated manner and identify LRAT as a critical component of this process.

  5. Lrat KO mice exhibited increased levels of retinoic acid-responsive genes, including p21 (show D4S234E Antibodies).

  6. Analyses revealed that LRAT undergoes spontaneous, covalent modification upon incubation with a variety of phosphatidylcholine (show SGMS2 Antibodies) substrates. The addition of an acyl chain occurs at the Cys (show DNAJC5 Antibodies)(161) residue, indicating formation of a thioester intermediate.

  7. FATP1 inhibits 11-cis (show CISH Antibodies) retinol formation via interaction with the visual cycle retinoid isomerase RPE65 (show RPE65 Antibodies) and lecithin:retinol acyltransferase

  8. Data show that overexpression of human LRAT specifically in mice oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis.

  9. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver

  10. LRAT has a role in retinoid absorption and storage

LRAT Antigen Profile

Protein Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.

Gene names and symbols associated with LRAT

  • lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (LRAT) antibody
  • lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) (Lrat) antibody
  • 1300010A18Rik antibody
  • AI449251 antibody
  • LCA14 antibody

Protein level used designations for LRAT

lecithin retinol acyltransferase , phosphatidylcholine--retinol O-acyltransferase , phosphatidylcholine-retinol-O-acyltransferase , lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)

GENE ID SPECIES
9227 Homo sapiens
281285 Bos taurus
79235 Mus musculus
64047 Rattus norvegicus
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