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LCAT encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. Additionally we are shipping LCAT Proteins (38) and LCAT Kits (35) and many more products for this protein.
Showing 10 out of 113 products:
Human Polyclonal LCAT Primary Antibody for ICC, IF - ABIN438375
Lee, Badeau, Mulya, Boudyguina, Gebre, Smith, Parks: Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice. in Journal of lipid research 2007
Show all 3 references for ABIN438375
Human Polyclonal LCAT Primary Antibody for FACS, IF - ABIN653825
Weissglas-Volkov, Aguilar-Salinas, Sinsheimer, Riba, Huertas-Vazquez, Ordoñez-Sánchez, Rodriguez-Guillen, Cantor, Tusie-Luna, Pajukanta: Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. in Circulation. Cardiovascular genetics 2010
Show all 3 references for ABIN653825
Cow (Bovine) Polyclonal LCAT Primary Antibody for WB - ABIN2776941
Calabresi, Pisciotta, Costantin, Frigerio, Eberini, Alessandrini, Arca, Bon, Boscutti, Busnach, Frascà, Gesualdo, Gigante, Lupattelli, Montali, Pizzolitto, Rabbone, Rolleri, Ruotolo, Sampietro, Sessa, Vaudo, Cantafora, Veglia, Calandra, Bertolini, Frances: The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families. in Arteriosclerosis, thrombosis, and vascular biology 2005
Show all 2 references for ABIN2776941
Human Polyclonal LCAT Primary Antibody for EIA, FACS - ABIN953145
McGeachie, Ramoni, Mychaleckyj, Furie, Dreyfuss, Liu, Herrington, Guo, Lima, Post, Rotter, Rich, Sale, Ramoni: Integrative predictive model of coronary artery calcification in atherosclerosis. in Circulation 2009
Show all 2 references for ABIN953145
Cow (Bovine) Polyclonal LCAT Primary Antibody for WB - ABIN2776942
Aranda, Valdivielso, Pisciotta, Garcia, Garcã A-Arias, Bertolini, Martã N-Reyes, Gonzã Lez-Santos, Calandra: Therapeutic management of a new case of LCAT deficiency with a multifactorial long-term approach based on high doses of angiotensin II receptor blockers (ARBs). in Clinical nephrology 2008
increased cholesterol esterification by LCAT is atheroprotective
Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.2- and 2.9-fold increase, respectively.
DYRK1A (show DYRK1A Antibodies) overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I (show APOA1 Antibodies) levels.
adrenal glucocorticoid function in LCAT knockout (KO) mice
a novel function of apoA-IV (show APOA4 Antibodies) in the biogenesis of discrete HDL (show HSD11B1 Antibodies)-A-IV particles with the participation of ABCA1 (show ABCA1 Antibodies) and LCAT
Studies suggest that absence of lecithin cholesterol acyltransferase (LCAT) may protect against insulin (show INS Antibodies) resistance, diabetes and obesity.
Data show that LCAT activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (show SPTLC2 Antibodies))+/- and sphingomyelin synthase 2 (Sms2 (show SGMS2 Antibodies))-/- mice, but markedly lower in ApoE (show APOE Antibodies)-/- and Ldlr (show LDLR Antibodies)-/- mice.
LCAT deficiency confers gender-specific protection against diet-induced obesity and insulin (show INS Antibodies) resistance at least in part through regulation in UPR, white adipose tissue adipogenesis, and brown adipocyte partitioning
Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E (show APOE Antibodies) knockout background in association with a reduction in atherosclerosis
LCAT contributes significantly to the cholesteryl ester (CE) fatty acid pool of apoB (show APOB Antibodies) lipoprotein and is the only source of plasma long chain polyunsaturated CE in LDL receptor (show LDLR Antibodies) and apoE (show APOE Antibodies) knockout mice.
Mapping the naturally occurring mutations onto the structure provides insight into how they may affect LCAT enzymatic activity.
Report slightly reduction in LCAT that would probably reflect a delay in reverse cholesterol transport occurring in MetS (show ETV3 Antibodies).
rs5923 polymorphism is not associated with low high-density lipoprotein cholesterol(HDL (show HSD11B1 Antibodies)-C)levels in Iranian population
The data indicate that this novel apoA-I (show APOA1 Antibodies) missense is associated with markedly decreased levels of HDL (show HSD11B1 Antibodies) cholesterol and very large alpha-1 HDL (show HSD11B1 Antibodies), as well as decreased serum cellular cholesterol efflux and LCAT activity
A robust all-atom model for LCAT generated by homology modeling
This study investigated how the natural LCAT[T147I] and LCAT[P274S] mutations affect the pathway of biogenesis of high-density lipoproteins.
A synonymous H287H mutation in the coding region of exon 6 of the lecithin cholesterol acyltransferase gene was observed in an individual with HDLC levels of 75 mg/dl.
Cosyntropin testing in an unselected subgroup of 8 ABCA1 (show ABCA1 Antibodies) mutation carriers and 3 LCAT mutation carriers did not reveal differences between carriers and controls.
The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits its toxic effect on cultured neurons.
The 1,434 bp mRNA sequence of porcine LCAT including the full coding region and encoding a protein of 472 amino acids, was obtained.
LCAT cholesterol esterification is associated with the increase of ApoE (show APOE Antibodies)/ApoA-I (show APOA1 Antibodies) ratio during atherosclerosis progression in rabbit.
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.
, lecithin cholesterol acyltransferase
, phosphatidylcholine-sterol acyltransferase
, lecithin-cholesterol acyltransferase Lcat
, phospholipid-cholesterol acyltransferase
, Lecithin-cholesterol acyltransferase