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LCAT encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. Additionally we are shipping LCAT Antibodies (112) and LCAT Proteins (38) and many more products for this protein.
Showing 10 out of 35 products:
Human LCAT ELISA Kit for Sandwich ELISA - ABIN572371
Fais, Cacace, Atzori, Era, Ruggiero: Plasma phospholipase, γ-CEHC and antioxidant capacity in fibromyalgia. in International journal of rheumatic diseases 2015
increased cholesterol esterification by LCAT is atheroprotective
Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.2- and 2.9-fold increase, respectively.
DYRK1A (show DYRK1A ELISA Kits) overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I (show APOA1 ELISA Kits) levels.
adrenal glucocorticoid function in LCAT knockout (KO) mice
a novel function of apoA-IV (show APOA4 ELISA Kits) in the biogenesis of discrete HDL (show HSD11B1 ELISA Kits)-A-IV particles with the participation of ABCA1 (show ABCA1 ELISA Kits) and LCAT
Studies suggest that absence of lecithin cholesterol acyltransferase (LCAT) may protect against insulin (show INS ELISA Kits) resistance, diabetes and obesity.
Data show that LCAT activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (show SPTLC2 ELISA Kits))+/- and sphingomyelin synthase 2 (Sms2 (show SGMS2 ELISA Kits))-/- mice, but markedly lower in ApoE (show APOE ELISA Kits)-/- and Ldlr (show LDLR ELISA Kits)-/- mice.
LCAT deficiency confers gender-specific protection against diet-induced obesity and insulin (show INS ELISA Kits) resistance at least in part through regulation in UPR, white adipose tissue adipogenesis, and brown adipocyte partitioning
Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E (show APOE ELISA Kits) knockout background in association with a reduction in atherosclerosis
LCAT contributes significantly to the cholesteryl ester (CE) fatty acid pool of apoB (show APOB ELISA Kits) lipoprotein and is the only source of plasma long chain polyunsaturated CE in LDL receptor (show LDLR ELISA Kits) and apoE (show APOE ELISA Kits) knockout mice.
Mapping the naturally occurring mutations onto the structure provides insight into how they may affect LCAT enzymatic activity.
Report slightly reduction in LCAT that would probably reflect a delay in reverse cholesterol transport occurring in MetS.
rs5923 polymorphism is not associated with low high-density lipoprotein cholesterol(HDL (show HSD11B1 ELISA Kits)-C)levels in Iranian population
The data indicate that this novel apoA-I (show APOA1 ELISA Kits) missense is associated with markedly decreased levels of HDL (show HSD11B1 ELISA Kits) cholesterol and very large alpha-1 HDL (show HSD11B1 ELISA Kits), as well as decreased serum cellular cholesterol efflux and LCAT activity
A robust all-atom model for LCAT generated by homology modeling
This study investigated how the natural LCAT[T147I] and LCAT[P274S] mutations affect the pathway of biogenesis of high-density lipoproteins.
A synonymous H287H mutation in the coding region of exon 6 of the lecithin cholesterol acyltransferase gene was observed in an individual with HDLC levels of 75 mg/dl.
Cosyntropin testing in an unselected subgroup of 8 ABCA1 (show ABCA1 ELISA Kits) mutation carriers and 3 LCAT mutation carriers did not reveal differences between carriers and controls.
The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits its toxic effect on cultured neurons.
The 1,434 bp mRNA sequence of porcine LCAT including the full coding region and encoding a protein of 472 amino acids, was obtained.
LCAT cholesterol esterification is associated with the increase of ApoE (show APOE ELISA Kits)/ApoA-I (show APOA1 ELISA Kits) ratio during atherosclerosis progression in rabbit.
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.
, lecithin cholesterol acyltransferase
, phosphatidylcholine-sterol acyltransferase
, lecithin-cholesterol acyltransferase Lcat
, phospholipid-cholesterol acyltransferase
, Lecithin-cholesterol acyltransferase