Lecithin-Cholesterol Acyltransferase Proteins (LCAT)

LCAT encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. Additionally we are shipping LCAT Antibodies (117) and LCAT Kits (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LCAT 3931 P04180
LCAT 16816 P16301
LCAT 24530  
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Top LCAT Proteins at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$327.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$251.74
Details
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$442.75
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$3,035.21
Details
Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
HEK-293 Cells Human DYKDDDDK Tag   1 mg Log in to see 2 to 3 Days
$6,240.93
Details

LCAT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus) ,

More Proteins for Lecithin-Cholesterol Acyltransferase (LCAT) Interaction Partners

Human Lecithin-Cholesterol Acyltransferase (LCAT) interaction partners

  1. data suggests a model wherein the active site of LCAT is shielded from soluble substrates by a dynamic lid until it interacts with HDL (show HSD11B1 Proteins) to allow transesterification to proceed

  2. Increased LCAT activity may be associated with increased formation of triglyceride rich lipoproteins, leading to a reduction in LDL particle size and atherosclerosis.

  3. Mapping the naturally occurring mutations onto the structure provides insight into how they may affect LCAT enzymatic activity.

  4. Report slightly reduction in LCAT that would probably reflect a delay in reverse cholesterol transport occurring in MetS.

  5. rs5923 polymorphism is not associated with low high-density lipoprotein cholesterol(HDL (show HSD11B1 Proteins)-C)levels in Iranian population

  6. increased cholesterol esterification by LCAT is atheroprotective

  7. The data indicate that this novel apoA-I (show APOA1 Proteins) missense is associated with markedly decreased levels of HDL (show HSD11B1 Proteins) cholesterol and very large alpha-1 HDL (show HSD11B1 Proteins), as well as decreased serum cellular cholesterol efflux and LCAT activity

  8. A robust all-atom model for LCAT generated by homology modeling

  9. This study investigated how the natural LCAT[T147I] and LCAT[P274S] mutations affect the pathway of biogenesis of high-density lipoproteins.

  10. A synonymous H287H mutation in the coding region of exon 6 of the lecithin cholesterol acyltransferase gene was observed in an individual with HDLC levels of 75 mg/dl.

Mouse (Murine) Lecithin-Cholesterol Acyltransferase (LCAT) interaction partners

  1. Taken together, these results suggest that apoE (show APOE Proteins)-containing discoidal HDLs (show CSF1R Proteins) do not require LCAT-dependent maturation to mediate efficient Abeta (show APP Proteins) clearance

  2. increased cholesterol esterification by LCAT is atheroprotective

  3. Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.2- and 2.9-fold increase, respectively.

  4. DYRK1A (show DYRK1A Proteins) overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I (show APOA1 Proteins) levels.

  5. adrenal glucocorticoid function in LCAT knockout (KO) mice

  6. a novel function of apoA-IV (show APOA4 Proteins) in the biogenesis of discrete HDL (show HSD11B1 Proteins)-A-IV particles with the participation of ABCA1 (show ABCA1 Proteins) and LCAT

  7. Studies suggest that absence of lecithin cholesterol acyltransferase (LCAT) may protect against insulin (show INS Proteins) resistance, diabetes and obesity.

  8. Data show that LCAT activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (show SPTLC2 Proteins))+/- and sphingomyelin synthase 2 (Sms2 (show SGMS2 Proteins))-/- mice, but markedly lower in ApoE (show APOE Proteins)-/- and Ldlr (show LDLR Proteins)-/- mice.

  9. LCAT deficiency confers gender-specific protection against diet-induced obesity and insulin (show INS Proteins) resistance at least in part through regulation in UPR, white adipose tissue adipogenesis, and brown adipocyte partitioning

  10. Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E (show APOE Proteins) knockout background in association with a reduction in atherosclerosis

Rabbit Lecithin-Cholesterol Acyltransferase (LCAT) interaction partners

  1. LCAT cholesterol esterification is associated with the increase of ApoE (show APOE Proteins)/ApoA-I (show APOA1 Proteins) ratio during atherosclerosis progression in rabbit.

Pig (Porcine) Lecithin-Cholesterol Acyltransferase (LCAT) interaction partners

  1. The 1,434 bp mRNA sequence of porcine LCAT including the full coding region and encoding a protein of 472 amino acids, was obtained.

LCAT Protein Profile

Protein Summary

This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.

Gene names and symbols associated with LCAT

  • lecithin-cholesterol acyltransferase (LCAT)
  • lecithin cholesterol acyltransferase (Lcat)
  • lecithin-cholesterol acyltransferase L homeolog (lcat.L)
  • lecithin-cholesterol acyltransferase (lcat)
  • solute carrier family 12 member 4 (SLC12A4)
  • lecithin-cholesterol acyltransferase (Lcat)
  • fragile site, aphidicolin type, common, fra(13)(q13.2) (FRA13A)
  • AI046659 protein
  • D8Wsu61e protein
  • LCAT protein
  • MGC82035 protein
  • MGC88964 protein

Protein level used designations for LCAT

phosphatidylcholine-sterol acyltransferase , phospholipid-cholesterol acyltransferase , lecithin-cholesterol acyltransferase Lcat , lecithin-cholesterol acyltransferase , lecithin cholesterol acyltransferase , Lecithin-cholesterol acyltransferase

GENE ID SPECIES
3931 Homo sapiens
16816 Mus musculus
396136 Gallus gallus
447501 Xenopus laevis
448241 Xenopus (Silurana) tropicalis
479680 Canis lupus familiaris
510960 Bos taurus
743056 Pan troglodytes
100008978 Oryctolagus cuniculus
100126664 Papio anubis
100302343 Ovis aries
100303723 Sus scrofa
100389625 Callithrix jacchus
100469078 Ailuropoda melanoleuca
100528492 Ictalurus punctatus
24530 Rattus norvegicus
100053753 Equus caballus
100727686 Cavia porcellus
793137 Danio rerio
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