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LGALS8 encodes a member of the galectin family. Additionally we are shipping Lectin, Galactoside-Binding, Soluble, 8 Kits (47) and Lectin, Galactoside-Binding, Soluble, 8 Proteins (30) and many more products for this protein.
Showing 10 out of 98 products:
Human Monoclonal LGALS8 Primary Antibody for ELISA, WB - ABIN394563
Cludts, Decaestecker, Mahillon, Chevalier, Kaltner, André, Remmelink, Leroy, Gabius, Saussez: Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7. in Anticancer research 2010
Show all 5 references for 394563
Cow (Bovine) Polyclonal LGALS8 Primary Antibody for WB - ABIN2785503
Yamamoto, Nishi, Shoji, Itoh, Lu, Hirashima, Nakamura: Induction of cell adhesion by galectin-8 and its target molecules in Jurkat T-cells. in Journal of biochemistry 2008
Human Polyclonal LGALS8 Primary Antibody for IHC, ELISA - ABIN1534464
Gopalkrishnan, Roberts, Tuli, Kang, Christiansen, Fisher: Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. in Oncogene 2000
these data suggest that Gal-8 promotes the differentiation of highly suppressive Treg cells, which has implications for the treatment of inflammatory and autoimmune diseases.
this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C (show VEGFC Antibodies), podoplanin (show PDPN Antibodies) and integrin pathways plays a key role.
Gal (show GAL Antibodies)-8mut was unable to induce T-cell proliferation, but efficiently co-stimulated antigen-specific responses, bothin vitroandin vivo.
Gal-8 emerges as an attractive therapeutic candidate.
Galectin-8 induces RANKL (show TNFSF11 Antibodies) expression, osteoclastogenesis, and bone mass reduction in mice.
Gal-8 stimulated naive T cells, but had an antiproliferative effect when these cells were activated.A dose of recombinant Gal-8 administered with a suboptimal Ag dose to DO11.10 mice strengthened weak responses in vivo.
a novel role for Gal-8 in collaboration with Gal-1 (show LGALS1 Antibodies) in plasma cell formation, and suggest the possibility of using distinct LacNAc ligands to modulate the function of Gals.
The findings of the present study delineate the differential molecular requirements for Gal-8 activities on T-cells, and suggest a dual activity relying on activation state.
downstream effectors of PI3K, including PKB (show AKT2 Antibodies) and p70 S6 kinase (show PRKACB Antibodies), in part mediate cell adhesion, spreading, and microspike formation induced by galectin-8
galectin-8 is expressed in the thymus in mouse, which suggests an active role for this lectin in shaping the mature T cell repertoire
Data suggest that galectin-8 is a potential independent favorable prognostic biomarker for survival and recurrence of patients with gastric cancer after surgery.
Platelet-derived factor V/Va is generated following endocytosis of the plasma-derived molecule by the platelet precursor cells, megakaryocytes, via a two receptor system consisting of LRP-1 (show LRP1 Antibodies) and an unidentified specific "binding site".
Gal-8 expression is a potential independent unfavorable prognostic indicator for postoperative recurrence of patients with localized pT1 (show ZNF77 Antibodies) clear cell renal cell carcinoma (show MOK Antibodies)
The fundamental roles of galectin-8 in human anaplastic large cell lymphoma
The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis
We integrate here the available information on Gal-8 expression in different tumor types and attempt to elucidate associations of its expression and localization with tumor progression[review]
these results not only confirm the pro-inflammatory role we have already proposed for Gal-8 in other cellular systems but also suggest that this lectin is orchestrating the interaction between leukocytes, platelets and endothelial cells
Whereas Galectin (Gal)-1, -3, and -8 triggered vascular endothelial growth factor (VEGF) release, only Gal-8 induced endostatin secretion.
Focusing on the F19Y change in galectin-8, we study of consequences of a single-site substitution in the carbohydrate recognition domain of this family of cellular effectors.
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.
lectin, galactoside-binding, soluble, 8
, lectin, galactoside-binding, soluble, 8 (galectin 8)
, galectin 8
, lectin, galactose binding, soluble 5
, galectin-8 variant II
, Po66 carbohydrate binding protein
, po66 carbohydrate-binding protein
, prostate carcinoma tumor antigen 1
, 30 kDa S-type lectin
, lectin, galactose binding, soluble 8
, galectin family xgalectin-VIIIa