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Lectin, Mannose-Binding, 1 Proteins (LMAN1)

The protein encoded by LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. Additionally we are shipping LMAN1 Antibodies (34) and LMAN1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LMAN1 3998 P49257
LMAN1 70361 Q9D0F3
Rat LMAN1 LMAN1 116666 Q62902
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Top LMAN1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

LMAN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,
,

More Proteins for Lectin, Mannose-Binding, 1 (LMAN1) Interaction Partners

Human Lectin, Mannose-Binding, 1 (LMAN1) interaction partners

  1. Mannan-binding lectin (show MBL2 Proteins) reduces CpG DNA-induced inflammatory cytokine production in monocytes.

  2. MMP-9 (show MMP9 Proteins) secretion was reduced in the LMAN1 knockout cell line compared to control cells confirming the functional role of LMAN1.

  3. Authors identified a class of pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their association with ERGIC-53, and a role for ERGIC-53 in the propagation of several highly pathogenic RNA virus families.

  4. Studies indicate that the LMAN1-CRD (show CRX Proteins) contains distinct, separable binding sites for both its partner protein MCFD2 (show MCFD2 Proteins) and the cargo proteins FV/FVIII (show F8 Proteins).

  5. Data indicate that together with its soluble coreceptor MCFD2 (show MCFD2 Proteins), LMAN1 transports coagulation factors V (FV) and VIII (show COX8A Proteins) (FVIII (show F8 Proteins)).

  6. Mutations in LMAN1 lead to F5F8D (combined deficiency of factor V And factor VIII) due to alterations in LMAN1-MCFD2 (show MCFD2 Proteins) complex of coat protein (show GOLPH3 Proteins) (COP (show CARD16 Proteins))II complex trafficking machinery; 70% of F5F8D patients have mutations in LMAN1. [REVIEW]

  7. UBXD1 (show UBXN6 Proteins) modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53.

  8. Two new mutations at ERGIC-53 gene in a Turkish family.

  9. Data present the crystal structure of the LMAN1/MCFD2 (show MCFD2 Proteins) complex and relate it to patient mutations. Circular dichroism data show that the majority of the substitution mutations give rise to a disordered or severely destabilized MCFD2 (show MCFD2 Proteins) protein.

  10. Data show that mutations in MCFD2 (show MCFD2 Proteins) that disrupt the tertiary structure and abolish LMAN1 binding still retain the FV/FVIII (show F8 Proteins) binding activities, suggesting that this interaction is independent of Ca(2 (show CA2 Proteins)+)-induced folding of the protein.

Mouse (Murine) Lectin, Mannose-Binding, 1 (LMAN1) interaction partners

  1. LMAN1 may play a role in photoreceptor gene transport and homeostasis.

  2. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin.

  3. surfactant proteins A and D and mannose-binding lectin (show MBL2 Proteins) play roles in inflammation caused by DNA in lungs and other tissues

  4. ERGIC-53 gene transcription is regulated in response to endoplasmic reticulum stress

LMAN1 Protein Profile

Protein Summary

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

Gene names and symbols associated with LMAN1

  • lectin, mannose-binding, 1 (LMAN1)
  • complexin 3 (cplx3)
  • lectin, mannose-binding, 1 (lman1)
  • lectin, mannose-binding, 1 (Lman1)
  • 2610020P13Rik protein
  • AI326273 protein
  • AU043785 protein
  • C730041J05 protein
  • cpx-iii protein
  • cpxiii protein
  • ERGIC-53 protein
  • ERGIC53 protein
  • F5F8D protein
  • FMFD1 protein
  • gp58 protein
  • lman1 protein
  • lman1-a protein
  • MCFD1 protein
  • MR60 protein
  • P58 protein
  • wu:fc54c09 protein
  • wu:fi36e01 protein
  • Xp58 protein

Protein level used designations for LMAN1

lectin, mannose-binding, 1 , lectin mannose-binding 1 , ER-Golgi intermediate compartment 53 kDa protein , protein ERGIC-53 , protein ERGIC-53-like , fc54c09 , fi36e01 , endoplasmic reticulum-golgi intermediate compartment protein 53 , intracellular mannose specific lectin , intracellular mannose-specific lectin MR60 , ERGIC-53 protein , intracellular mannose specific lectin MR60

GENE ID SPECIES
431779 Canis lupus familiaris
455448 Pan troglodytes
496634 Xenopus (Silurana) tropicalis
697449 Macaca mulatta
100021881 Monodelphis domestica
100354112 Oryctolagus cuniculus
100404326 Callithrix jacchus
100475249 Ailuropoda melanoleuca
100562643 Anolis carolinensis
100592766 Nomascus leucogenys
559775 Danio rerio
394295 Xenopus laevis
426849 Gallus gallus
3998 Homo sapiens
476186 Canis lupus familiaris
511649 Bos taurus
70361 Mus musculus
116666 Rattus norvegicus
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