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Left-Right Determination Factor 1 Proteins (LEFTY1)

LEFTY1 encodes a member of the TGF-beta family of proteins. Additionally we are shipping Left-Right Determination Factor 1 Antibodies (65) and Left-Right Determination Factor 1 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LEFTY1 13590 Q64280
LEFTY1 498299  
LEFTY1 10637 O75610
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Top Left-Right Determination Factor 1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$1,338.75
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$823.90
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details

LEFTY1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
,
Rat (Rattus)

Human , ,
,

More Proteins for Left-Right Determination Factor 1 (LEFTY1) Interaction Partners

Zebrafish Left-Right Determination Factor 1 (LEFTY1) interaction partners

  1. Our data do not support the reaction-diffusion model, but instead, we propose that Nodal activates signaling in a temporal window that is defined by a miR (show MYLIP Proteins)-430-mediated delay of Lft1/2 translation

  2. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty (show LEFTY2 Proteins) range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning

  3. both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning

  4. Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4 (show BMP4 Proteins).

  5. we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 (show LEFTY2 Proteins) transcription

  6. study reports that microRNA-430 (miR (show MYLIP Proteins)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (show TGFB1 Proteins) Nodal antagonist lefty (show LEFTY2 Proteins)

Mouse (Murine) Left-Right Determination Factor 1 (LEFTY1) interaction partners

  1. exogenous lefty1 administered to mice restored the endogenous expression levels of lefty1. The present study demonstrated that lefty1 attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (show TGFB1 Proteins) signaling pathway

  2. Lefty-1 may prevent TGFB1 (show TGFB1 Proteins)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (show SMAD3 Proteins), JNK-3 (show MAPK10 Proteins), and BMP-5 (show BMP5 Proteins) signaling.

  3. The expression of lefty (show LEFTY2 Proteins) in RCC (show XRCC1 Proteins) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Proteins).

  4. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2 (show LEFTY2 Proteins)) has a conserved role in left-right asymmetry.

  5. Taken together, these results suggest that optimal expression of Lefty1 and Lefty2 (show LEFTY2 Proteins) is critical for the balanced differentiation of mESCs into three germ layers.

  6. Beta-catenin can recrui (show KDM1A Proteins)t the H3K4me2/1 d (show CTNNB1 Proteins)emethylase LSD1 to regulate the expression of the tumor suppressor Lefty1 in mouse embryonic stem cells.

  7. Lefty (show LEFTY2 Proteins) can antagonise TGF-beta1 (show TGFB1 Proteins) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.

  8. Cerberus (show CER1 Proteins)-like and Lefty-1 function redundantly to modulate Nodal signaling during gastrulation and regulate patterning of the primitive streak

  9. Regulated expression and spatial distribution of lefty (show LEFTY2 Proteins) in mouse endometrium confines its biological impact on tissues that undergo remodelling during estrous cycle and pregnancy.

  10. findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty (show LEFTY2 Proteins) by PC5/6A (show PCSK5 Proteins)

Human Left-Right Determination Factor 1 (LEFTY1) interaction partners

  1. Lefty1 could regulates the cell cycle via modulating the expressions of P57 (show CDKN1C Proteins) and cyclin D1 (show CCND1 Proteins) and then inhibit the decidualization in vitro.

  2. The mRNA levels of LSD1 (show KDM1A Proteins) and beta-catenin (show CTNNB1 Proteins) are inversely correlated with the levels of Lefty1 in pancreas and breast tumors.

  3. Reprogrammed cancer cells share the mechanism for expression of Lefty (show LEFTY2 Proteins) with induced pluripotent cancer cells (iPS (show SLC27A4 Proteins)), thus contributing to the cancerous transformation of iPS (show SLC27A4 Proteins) cells.

  4. Data suggest that Lefty (show LEFTY2 Proteins) is a novel TGF-beta (show TGFB1 Proteins) target molecule that mediates growth inhibition of pancreatic cancer cells.

  5. Findings suggest that Lefty1 is negatively modulated by miR (show MLXIP Proteins)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.

  6. The expression of Nodal in normal and malignant endometrial cells that lack Lefty (show LEFTY2 Proteins) strongly supports an important role for this embryonic morphogen (show SHH Proteins) in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis.

  7. nodal and the inhibitors of Nodal signaling, lefty (show LEFTY2 Proteins)-A and lefty (show LEFTY2 Proteins)-B, are down-regulated very early upon differentiation of human embryonic stem cells

  8. LEFTY (show LEFTY2 Proteins) proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

Left-Right Determination Factor 1 (LEFTY1) Protein Profile

Protein Summary

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

Gene names and symbols associated with LEFTY1

  • lefty1 (lft1)
  • signaling molecule lefty1 (lefty1)
  • left-right determination factor 1 (LEFTY1)
  • left right determination factor 1 (Lefty1)
  • AI450052 protein
  • antivin protein
  • atv protein
  • cb73 protein
  • Ebaf protein
  • ik:tdsubc_2b12 protein
  • LEFTB protein
  • lefty protein
  • lefty-1 protein
  • LEFTY1 protein
  • LEFTYB protein
  • RGD1561867 protein
  • Stra3 protein
  • Tgfb4 protein
  • xx:tdsubc_2b12 protein

Protein level used designations for LEFTY1

signaling molecule lefty1 , left-right determination factor 1 , left-right determination, factor B , left-right determination factor 1-like , TGF-beta-4 , protein lefty-1 , stimulated by retinoic acid gene 3 protein , transforming growth factor beta-4 , left-right determination factor B , protein lefty-B

GENE ID SPECIES
30145 Danio rerio
100049252 Oryzias latipes
699924 Macaca mulatta
737178 Pan troglodytes
100408003 Callithrix jacchus
100435934 Pongo abelii
100597378 Nomascus leucogenys
13590 Mus musculus
498299 Rattus norvegicus
10637 Homo sapiens
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