anti-Left-Right Determination Factor 2 (LEFTY2) Antibodies

LEFTY2 encodes a member of the TGF-beta family of proteins. Additionally we are shipping LEFTY2 Proteins (11) and LEFTY2 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LEFTY2 13590 Q64280
LEFTY2 7044 O00292
LEFTY2 289316  
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Top anti-LEFTY2 Antibodies at

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-LEFTY2 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>RPMI 8226 cell lysate Immunohistochemistry with Uterus tissue at an antibody concentration of 5µg/ml using anti-LEFTY2 antibody (ARP42107_P050) 100 μL Log in to see 2 to 3 Days
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 10% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using LEFTY2, antibody at 1:500 dilution. 100 μL Log in to see 1 to 2 Days
Human Mouse Un-conjugated IHC, ELISA, WB 0.05 mg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated IHC (p), ELISA, WB Human Uterus, Myometrium (formalin-fixed, paraffin-embedded) stained with LEFTY2 antibody ABIN337262 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated WB Western blot analysis of TGF beta 4 expression in HepG2 (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated IHC (p), WB Anti-LEFTY2 antibody IHC staining of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959060 concentration 5 ug/ml. 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using LEFTY2 antibody. 100 μL Log in to see 16 Days

LEFTY2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
, , ,
Human ,
Rat (Rattus) ,

More Antibodies against LEFTY2 Interaction Partners

Zebrafish Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning

  2. we find that Cyclops is specifically required for the maintenance of lefty1 (show LEFTY1 Antibodies) and lefty2 transcription

  3. study reports that microRNA-430 (miR (show MYLIP Antibodies)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (show TGFB1 Antibodies) Nodal antagonist lefty

Mouse (Murine) Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Antibodies) and demethylation crucial to regulation of key signalling pathways in early body plan formation

  2. LEFTY2 regulates the expression and activity of ENaC (show SCNN1A Antibodies) in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).

  3. Results indicate that microRNA miR (show MLXIP Antibodies)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).

  4. exogenous lefty1 (show LEFTY1 Antibodies) administered to mice restored the endogenous expression levels of lefty1 (show LEFTY1 Antibodies). The present study demonstrated that lefty1 (show LEFTY1 Antibodies) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (show TGFB1 Antibodies) signaling pathway

  5. Lefty-1 (show LEFTY1 Antibodies) may prevent TGFB1 (show TGFB1 Antibodies)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (show SMAD3 Antibodies), JNK-3 (show MAPK10 Antibodies), and BMP-5 (show BMP5 Antibodies) signaling.

  6. The expression of lefty in RCC (show XRCC1 Antibodies) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Antibodies).

  7. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.

  8. Taken together, these results suggest that optimal expression of Lefty1 (show LEFTY1 Antibodies) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.

  9. Beta-catenin (show CTNNB1 Antibodies) can recruit the H3K4me2/1 demethylase (show MBD2 Antibodies) LSD1 (show KDM1A Antibodies) to regulate the expression of the tumor suppressor Lefty1 (show LEFTY1 Antibodies) in mouse embryonic stem cells.

  10. Lefty can antagonise TGF-beta1 (show TGFB1 Antibodies) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.

Human Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. LEFTY2 down-regulates MKi67 (show MKI67 Antibodies) expression and FAK (show PTK2 Antibodies) activity, up-regulates miR (show MLXIP Antibodies)-200a and E-cadherin (show CDH1 Antibodies), and is thus a powerful negative regulator of endometrial cell proliferation and migration.

  2. LEFTY2 regulates the expression and activity of ENaC (show SCNN1A Antibodies) in endometrial epithelial cells via SGK1 (show SGK1 Antibodies).

  3. Lefty A may account for the tumor suppressive activity of human adult stem cells.

  4. Findings suggest that Lefty2 is negatively modulated by miR (show MLXIP Antibodies)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.

  5. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression

  6. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells

  7. Addition of recombinant LEFTY-A to explants induced MMP-9 (show MMP9 Antibodies) in most samples, a response prevented by ovarian steroids.

  8. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

LEFTY2 Antigen Profile

Protein Summary

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with LEFTY2

  • lefty2 (lft2) antibody
  • left-right determination factor 2 (LEFTY2) antibody
  • left-right determination factor 2 (LOC100232580) antibody
  • left right determination factor 1 (Lefty1) antibody
  • left-right determination factor 2 (Lefty2) antibody
  • Left-right determination factor 2 (Lefty2) antibody
  • 6030463A22Rik antibody
  • AI450052 antibody
  • atv2 antibody
  • AV214969 antibody
  • cb720 antibody
  • EBAF antibody
  • Ebaf2 antibody
  • fe38b03 antibody
  • Lefta antibody
  • Leftb antibody
  • lefty antibody
  • lefty-1 antibody
  • LEFTY1 antibody
  • LEFTYA antibody
  • Stra3 antibody
  • TGFB4 antibody
  • wu:fe38b03 antibody

Protein level used designations for LEFTY2

lefty , endometrial bleeding associated factor , left-right determination factor 1 , left-right determination factor 2 , left-right determination factor 2-like , TGF-beta-4 , left-right determination, factor B , protein lefty-1 , stimulated by retinoic acid gene 3 protein , transforming growth factor beta-4 , endometrial bleeding-associated factor , left-right determination factor A , protein lefty-2 , protein lefty-A , left-right determination factor B , left-right determination, factor A , protein lefty-B

30146 Danio rerio
395529 Gallus gallus
457780 Pan troglodytes
490387 Canis lupus familiaris
699676 Macaca mulatta
100232580 Taeniopygia guttata
100435327 Pongo abelii
13590 Mus musculus
7044 Homo sapiens
320202 Mus musculus
289316 Rattus norvegicus
100337677 Sus scrofa
534018 Bos taurus
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