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anti-Legumain (LGMN) Antibodies

LGMN encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. Additionally we are shipping Legumain Proteins (18) and Legumain Kits (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LGMN 63865 Q9R0J8
LGMN 5641 Q99538
LGMN 19141 O89017
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Top anti-Legumain Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged LGMN is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB LGMN Antibody (N-term) (ABIN1881495) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the LGMN antibody detected the LGMN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-LGMN AntibodyTitration: 1.0 µg/mL  Positive Control: Fetal Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged LGMN is approximately 0.1ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colorectal cancer labeled with Anti Legumain Polyclonal Antibody, Unconjugated (ABIN750958) followed by conjugation to the secondary antibody and DAB staining Lane 1: rat brain lysates Lane 2: rat heart lysates probed with Anti Legumain Polyclonal Antibody, Unconjugated (ABIN750958) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 49kD. Observed band size: 49kD. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB Western Blot analysis of LGMN expression in transfected 293T cell line by LGMN MaxPab polyclonal antibody.Lane 1: LGMN transfected lysate(49.40 KDa).Lane 2: Non-transfected lysate. LGMN MaxPab rabbit polyclonal antibody. Western Blot analysis of LGMN expression in HeLa. 100 μg Log in to see 9 Days
$418.57
Details
Human Rabbit Un-conjugated IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 200 μL Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

LGMN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Legumain Antibodies

  1. Human Monoclonal LGMN Primary Antibody for ELISA - ABIN396827 : Sowa, Bennett, Gygi, Harper: Defining the human deubiquitinating enzyme interaction landscape. in Cell 2009 (PubMed)
    Show all 5 references for ABIN396827

  2. Human Polyclonal LGMN Primary Antibody for WB - ABIN1881495 : Clerin, Shih, Deng, Hebert, Resmini, Shields, Feldman, Winkler, Albert, Maganti, Wong, Paulsen, Keith, Vlasuk, Pittman: Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis. in Atherosclerosis 2009 (PubMed)
    Show all 3 references for ABIN1881495

  3. Human Polyclonal LGMN Primary Antibody for WB - ABIN519319 : Garcia-Cattaneo, Gobert, Müller, Toscano, Flores, Lescure, Del Nery, Benaroch: Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)

  4. Human Monoclonal LGMN Primary Antibody for ELISA - ABIN562455 : Liu, Bajjuri, Liu, Sinha: Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug. in Molecular pharmaceutics 2012 (PubMed)

More Antibodies against Legumain Interaction Partners

Arabidopsis thaliana Legumain (LGMN) interaction partners

  1. at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat

Human Legumain (LGMN) interaction partners

  1. legumain might play an important role in cervical cancer cell migration and invasion.

  2. Legumain appears to be involved in tumor development and deterioration.

  3. AEP acts as a delta-secretase, cleaving APP (show APP Antibodies) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP Antibodies). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  4. High legumain expression is associated with breast cancer.

  5. This unique feature was confirmed by the crystal structure of AEPpH4.5 (AEP was matured at pH 4.5 and crystallized at pH 8.5), in which the broken peptide bonds were religated and the structure was transformed back to its proenzyme form.

  6. High legumain activity is associated with breast cancer.

  7. AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.

  8. Identified an alternative oncogenic pathway for TRAF6 (show TRAF6 Antibodies) that uses AEP as its substrate. AEP and TRAF6 (show TRAF6 Antibodies) protein levels may have prognostic implications in breast cancer patients. Thus, AEP may serve as a biomarker as well as new therapeutic target

  9. the relationship among Legumain expression, clinicopathologic, biological variables and patient prognosis in gastric carcinoma

  10. HCT116 cells were transfected with p53 (show TP53 Antibodies) siRNA and the effect of knockdown of p53 (show TP53 Antibodies) expression on legumain expression was examined. The results showed that expression levels of both legumain mRNA and protein were decreased in the siRNA-treated cells.

Cow (Bovine) Legumain (LGMN) interaction partners

  1. legumain and TIMP-2 (show TIMP2 Antibodies) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy

Mouse (Murine) Legumain (LGMN) interaction partners

  1. AEP acts as a delta-secretase, cleaving APP (show APP Antibodies) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP Antibodies). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  2. results suggest that legumain expression and activation and cleavage of annexin A2 (show ANXA2 Antibodies) are regulated by DJ-1 (show PARK7 Antibodies) through p53 (show TP53 Antibodies)

  3. AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.

  4. TDP-43 (show TARDBP Antibodies) is cleaved by AEP in brain.

  5. TLR7 (show TLR7 Antibodies) requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling.

  6. We identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1 (show ICAM1 Antibodies)), and ras-related C3 botulinum toxin substrate 2 (RAC2 (show RAC2 Antibodies)), among others, in an invasive pre-B-cell line that produced leukemia in NOD-SCID (show PRKDC Antibodies) mice

  7. AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (show EGFR Antibodies)

  8. Immunohistochemical analyses revealed the expression of legumain in Iba1 (show AIF1 Antibodies)(+) microglial cells and glial fibrillary acidic protein (show GFAP Antibodies)-positive astrocytes of the peri (show POSTN Antibodies)-infarct area in mice after transient occlusion of the middle cerebral artery.

  9. AEP has a pivotal role in the endosomal/lysosomal degradation system

  10. unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E (show CST6 Antibodies) deficient mice.

Legumain (LGMN) Antigen Profile

Protein Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Gene names and symbols associated with anti-Legumain (LGMN) Antibodies

  • legumain-like (LOC100053265) antibody
  • legumain (lgmn) antibody
  • legumain (LGMN) antibody
  • delta vacuolar processing enzyme/legumain (DELTA-VPE) antibody
  • Legumain (Mboo_1489) antibody
  • Legumain (Odosp_3582) antibody
  • Legumain (lgmn) antibody
  • legumain (Lgmn) antibody
  • AEP antibody
  • AI746452 antibody
  • AU022324 antibody
  • cb173 antibody
  • cb460 antibody
  • delta vacuolar processing enzyme antibody
  • DELTAVPE antibody
  • lgmn antibody
  • LGMN1 antibody
  • MGC64351 antibody
  • MGC88980 antibody
  • PRSC1 antibody
  • sb:cb173 antibody
  • wu:fa98g05 antibody
  • wu:fj92g08 antibody
  • zgc:76953 antibody

Protein level used designations for anti-Legumain (LGMN) Antibodies

legumain , Legumain , asparaginyl endopeptidase , protease, cysteine 1 , protease, cysteine, 1 (legumain) , cysteine protease 1 , preprolegumain , protease, cysteine, 1

GENE ID SPECIES
100053265 Equus caballus
379601 Xenopus laevis
406625 Danio rerio
423418 Gallus gallus
448252 Xenopus (Silurana) tropicalis
821565 Arabidopsis thaliana
5410409 Methanoregula boonei 6A8
10255359 Odoribacter splanchnicus DSM 220712
100306856 Salmo salar
63865 Rattus norvegicus
5641 Homo sapiens
480232 Canis lupus familiaris
281281 Bos taurus
19141 Mus musculus
100173793 Pongo abelii
Selected quality suppliers for anti-Legumain (LGMN) Antibodies
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