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Legumain (LGMN) ELISA Kits

LGMN encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. Additionally we are shipping Legumain Antibodies (57) and Legumain Proteins (18) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
LGMN 63865 Q9R0J8
LGMN 5641 Q99538
LGMN 19141 O89017
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Top Legumain ELISA Kits at antibodies-online.com

Showing 4 out of 16 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.055 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$757.89
Details
Human 4.45 pg/mL 12.35-1000 pg/mL 96 Tests Log in to see 9 to 11 Days
$663.16
Details
Rat
  96 Tests Log in to see 11 to 13 Days
$875.60
Details
Cow
  96 Tests Log in to see 11 to 13 Days
$1,029.60
Details

More ELISA Kits for Legumain Interaction Partners

Arabidopsis thaliana Legumain (LGMN) interaction partners

  1. at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat

Human Legumain (LGMN) interaction partners

  1. legumain might play an important role in cervical cancer cell migration and invasion.

  2. Legumain appears to be involved in tumor development and deterioration.

  3. AEP acts as a delta-secretase, cleaving APP (show APP ELISA Kits) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP ELISA Kits). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  4. High legumain expression is associated with breast cancer.

  5. This unique feature was confirmed by the crystal structure of AEPpH4.5 (AEP was matured at pH 4.5 and crystallized at pH 8.5), in which the broken peptide bonds were religated and the structure was transformed back to its proenzyme form.

  6. High legumain activity is associated with breast cancer.

  7. AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.

  8. Identified an alternative oncogenic pathway for TRAF6 (show TRAF6 ELISA Kits) that uses AEP as its substrate. AEP and TRAF6 (show TRAF6 ELISA Kits) protein levels may have prognostic implications in breast cancer patients. Thus, AEP may serve as a biomarker as well as new therapeutic target

  9. the relationship among Legumain expression, clinicopathologic, biological variables and patient prognosis in gastric carcinoma

  10. HCT116 cells were transfected with p53 (show TP53 ELISA Kits) siRNA and the effect of knockdown of p53 (show TP53 ELISA Kits) expression on legumain expression was examined. The results showed that expression levels of both legumain mRNA and protein were decreased in the siRNA-treated cells.

Cow (Bovine) Legumain (LGMN) interaction partners

  1. legumain and TIMP-2 (show TIMP2 ELISA Kits) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy

Mouse (Murine) Legumain (LGMN) interaction partners

  1. AEP acts as a delta-secretase, cleaving APP (show APP ELISA Kits) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP ELISA Kits). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  2. results suggest that legumain expression and activation and cleavage of annexin A2 (show ANXA2 ELISA Kits) are regulated by DJ-1 (show PARK7 ELISA Kits) through p53 (show TP53 ELISA Kits)

  3. AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.

  4. TDP-43 (show TARDBP ELISA Kits) is cleaved by AEP in brain.

  5. TLR7 (show TLR7 ELISA Kits) requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling.

  6. We identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1 (show ICAM1 ELISA Kits)), and ras-related C3 botulinum toxin substrate 2 (RAC2 (show RAC2 ELISA Kits)), among others, in an invasive pre-B-cell line that produced leukemia in NOD-SCID (show PRKDC ELISA Kits) mice

  7. AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (show EGFR ELISA Kits)

  8. Immunohistochemical analyses revealed the expression of legumain in Iba1 (show AIF1 ELISA Kits)(+) microglial cells and glial fibrillary acidic protein (show GFAP ELISA Kits)-positive astrocytes of the peri (show POSTN ELISA Kits)-infarct area in mice after transient occlusion of the middle cerebral artery.

  9. AEP has a pivotal role in the endosomal/lysosomal degradation system

  10. unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E (show CST6 ELISA Kits) deficient mice.

Legumain (LGMN) Antigen Profile

Antigen Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Gene names and symbols associated with Legumain (LGMN) ELISA Kits

  • legumain-like (LOC100053265) antibody
  • legumain (lgmn) antibody
  • legumain (LGMN) antibody
  • delta vacuolar processing enzyme/legumain (DELTA-VPE) antibody
  • Legumain (Mboo_1489) antibody
  • Legumain (Odosp_3582) antibody
  • Legumain (lgmn) antibody
  • legumain (Lgmn) antibody
  • AEP antibody
  • AI746452 antibody
  • AU022324 antibody
  • cb173 antibody
  • cb460 antibody
  • delta vacuolar processing enzyme antibody
  • DELTAVPE antibody
  • lgmn antibody
  • LGMN1 antibody
  • MGC64351 antibody
  • MGC88980 antibody
  • PRSC1 antibody
  • sb:cb173 antibody
  • wu:fa98g05 antibody
  • wu:fj92g08 antibody
  • zgc:76953 antibody

Protein level used designations for Legumain (LGMN) ELISA Kits

legumain , Legumain , asparaginyl endopeptidase , protease, cysteine 1 , protease, cysteine, 1 (legumain) , cysteine protease 1 , preprolegumain , protease, cysteine, 1

GENE ID SPECIES
100053265 Equus caballus
379601 Xenopus laevis
406625 Danio rerio
423418 Gallus gallus
448252 Xenopus (Silurana) tropicalis
821565 Arabidopsis thaliana
5410409 Methanoregula boonei 6A8
10255359 Odoribacter splanchnicus DSM 220712
100306856 Salmo salar
63865 Rattus norvegicus
5641 Homo sapiens
480232 Canis lupus familiaris
281281 Bos taurus
19141 Mus musculus
100173793 Pongo abelii
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