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LGMN encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. Additionally we are shipping Legumain Antibodies (59) and Legumain Kits (16) and many more products for this protein.
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Mouse (Murine) LGMN Protein expressed in Human Cells - ABIN2007233
Dando, Fortunato, Smith, Knight, McKendrick, Barrett: Pig kidney legumain: an asparaginyl endopeptidase with restricted specificity. in The Biochemical journal 1999
Show all 4 references for ABIN2007233
at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat
legumain might play an important role in cervical cancer cell migration and invasion.
Legumain appears to be involved in tumor development and deterioration.
AEP acts as a delta-secretase, cleaving APP at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP. AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.
High legumain expression is associated with breast cancer.
This unique feature was confirmed by the crystal structure of AEPpH4.5 (AEP was matured at pH 4.5 and crystallized at pH 8.5), in which the broken peptide bonds were religated and the structure was transformed back to its proenzyme form.
High legumain activity is associated with breast cancer.
AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.
Identified an alternative oncogenic pathway for TRAF6 that uses AEP as its substrate. AEP and TRAF6 protein levels may have prognostic implications in breast cancer patients. Thus, AEP may serve as a biomarker as well as new therapeutic target
the relationship among Legumain expression, clinicopathologic, biological variables and patient prognosis in gastric carcinoma
HCT116 cells were transfected with p53 (show TP53 Proteins) siRNA and the effect of knockdown of p53 (show TP53 Proteins) expression on legumain expression was examined. The results showed that expression levels of both legumain mRNA and protein were decreased in the siRNA-treated cells.
legumain and TIMP-2 (show TIMP2 Proteins) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy
results suggest that legumain expression and activation and cleavage of annexin A2 (show ANXA2 Proteins) are regulated by DJ-1 (show PARK7 Proteins) through p53 (show TP53 Proteins)
TDP-43 is cleaved by AEP in brain.
TLR7 requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling.
We identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1 (show ICAM1 Proteins)), and ras-related C3 botulinum toxin substrate 2 (RAC2 (show RAC2 Proteins)), among others, in an invasive pre-B-cell line that produced leukemia in NOD-SCID (show PRKDC Proteins) mice
AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (show EGFR Proteins)
Immunohistochemical analyses revealed the expression of legumain in Iba1 (show AIF1 Proteins)(+) microglial cells and glial fibrillary acidic protein (show GFAP Proteins)-positive astrocytes of the peri (show POSTN Proteins)-infarct area in mice after transient occlusion of the middle cerebral artery.
AEP has a pivotal role in the endosomal/lysosomal degradation system
unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E (show CST6 Proteins) deficient mice.
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
, asparaginyl endopeptidase
, protease, cysteine 1
, protease, cysteine, 1 (legumain)
, cysteine protease 1
, protease, cysteine, 1