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anti-Leucine Carboxyl Methyltransferase 1 (LCMT1) Antibodies

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999. Additionally we are shipping Leucine Carboxyl Methyltransferase 1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LCMT1 51451 Q9UIC8
LCMT1 30949  
LCMT1 361643 Q6P4Z6
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Top anti-Leucine Carboxyl Methyltransferase 1 Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC200018 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LCMT1 antibody (ABIN2454744), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LCMT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LCMT1. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC200018 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LCMT1 antibody (ABIN2454742), and then analyzed by flow cytometry. Anti-LCMT1 mouse monoclonal antibody (ABIN2454742) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LCMT1 (RC200018). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-LCMT1 mouse monoclonal antibody (ABIN2454745) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LCMT1 (RC200018). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LCMT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LCMT1. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IHC, WB Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-LCMT1 mouse monoclonal antibody. (ABIN2454743) HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LCMT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LCMT1. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated FACS, IF, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$529.83
Details
Mouse Mouse Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$698.50
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of LCMT1 transfected lysate using anti-LCMT1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with LCMT1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of LCMT1 expression in transfected 293T cell line by LCMT1 MaxPab polyclonal antibody.Lane 1: LCMT1 transfected lysate(38.40 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated FACS   100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged LCMT1 is 0.3 ng/ml as a capture antibody. Western Blot detection against Immunogen (62.48 KDa) . 100 μg Log in to see 9 Days
$430.00
Details

LCMT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against Leucine Carboxyl Methyltransferase 1 Interaction Partners

Human Leucine Carboxyl Methyltransferase 1 (LCMT1) interaction partners

  1. LCMT1-PME-1 (show PPME1 Antibodies) methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  2. alterations in the membrane localization of PP2A (show PPP2R4 Antibodies) and Tau following down-regulation of LCMT1 may lead to PP2A (show PPP2R4 Antibodies) and Tau dysfunction in AD.

  3. Data indicate that PP2A (show PPP2R4 Antibodies) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 Antibodies) modulators, consisting of alpha4, PTPA (show PPP2R4 Antibodies), LCMT1, PME-1 (show PPME1 Antibodies) and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  4. GSK-3beta (show GSK3b Antibodies) can inhibit PP2A (show PPP2R4 Antibodies) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 (show PPME1 Antibodies) and inhibition of PPMT1

  5. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A (show PPP2R4 Antibodies) stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A (show PPP2R4 Antibodies)

  6. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet (show MAT1A Antibodies)) has been solved to a resolution of 2 A.

  7. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Mouse (Murine) Leucine Carboxyl Methyltransferase 1 (LCMT1) interaction partners

  1. In LCMT1 deficiency enzyme activity and methylation of PP2A (show PPP2R2B Antibodies) are reduced in a coordinate fashion, suggesting that LCMT1 is the only PP2A (show PPP2R2B Antibodies) methyltransferase.

  2. Enhanced expression of LCMT1 in cultured neuroblastoma cells, which increases endogenous methylated catalytic C subunit and Balpha levels, induces changes in F-actin organization.

  3. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Leucine Carboxyl Methyltransferase 1 (LCMT1) Antigen Profile

Protein Summary

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\; MIM 176915) (De Baere et al., 1999

Gene names and symbols associated with LCMT1

  • leucine carboxyl methyltransferase 1 (LCMT1) antibody
  • leucine carboxyl methyltransferase 1 (lcmt1) antibody
  • leucine carboxyl methyltransferase 1 (ANI_1_2090074) antibody
  • leucine carboxyl methyltransferase 1 (PTRG_02142) antibody
  • leucine carboxyl methyltransferase 1 (MCYG_00360) antibody
  • leucine carboxyl methyltransferase 1 (AOR_1_842194) antibody
  • leucine carboxyl methyltransferase 1 (Tsp_08223) antibody
  • leucine carboxyl methyltransferase 1 (Lcmt1) antibody
  • AL033290 antibody
  • Lcmt antibody
  • LCMT-1 antibody
  • MGC114784 antibody
  • PPMT1 antibody
  • zgc:101094 antibody

Protein level used designations for LCMT1

leucine carboxyl methyltransferase 1 , [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 , protein phosphatase methyltransferase 1 , protein-leucine O-methyltransferase

GENE ID SPECIES
416565 Gallus gallus
447907 Danio rerio
467930 Pan troglodytes
548787 Xenopus (Silurana) tropicalis
608360 Canis lupus familiaris
734508 Xenopus laevis
4983025 Aspergillus niger CBS 513.88
6338383 Pyrenophora tritici-repentis Pt-1C-BFP
9225317 Arthroderma otae CBS 113480
10099666 Aspergillus oryzae RIB40
10906787 Trichinella spiralis
100196453 Salmo salar
100528205 Ictalurus punctatus
100606762 Nomascus leucogenys
51451 Homo sapiens
30949 Mus musculus
361643 Rattus norvegicus
618021 Bos taurus
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