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Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. Additionally we are shipping Leucine Rich Repeat (In FLII) Interacting Protein 1 Antibodies (72) and Leucine Rich Repeat (In FLII) Interacting Protein 1 Kits (4) and many more products for this protein.
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Experiments in nude mice demonstrated better response of LRRFIP1 overexpressing glioblastoma multiforme xenografts to teniposide.
regulates a rapid type I interferon (show IFNA Proteins) response
LRRFIP1 and its downstream partner beta-catenin (show CTNNB1 Proteins) constitute another coactivator pathway for IRF3 (show IRF3 Proteins)-mediated production of type I interferon (show IFNA Proteins)
Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.
High GCF2 (show GCFC2 Proteins) expression is associated with hepatoma.
Higher baseline LRRFIP1 expression in human glioblastoma multiforme tissue (n=60) is associated with better prognosis upon later treatment with teniposide.
Data indicate that LRRFIP1 knockdown increased resting TNF (show TNF Proteins) mRNA level altered the ncRNA abundance at the LRRFIP1 binding region.
The FLI (show FLII Proteins)-interacting domain of LRRFIP1 forms a classic parallel, homodimeric coiled coil with 10 heptad repeats and 22 helical turns.
GCF2/LRRFIP1 plays an important role in colorectal cancer metastasis by regulating RhoA (show RHOA Proteins)-induced cell adhesion.
LRRFIP1 is phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures.
An association study of 6 of the 63 genes in 4235 cases and 6379 controls showed a putative association with myocardial infarction for COMMD7 (COMM domain-containing protein 7 (show COMMD7 Proteins)) and a major deviation from the null hypo thesis for LRRFIP1.
GCF2/LRRFIP1 appears to act as a repressor and occupies the -308 site in cells that do not make TNF-alpha (show TNF Proteins).
Immediately following lipopolysaccharide stimulation, both LRRFIP2 (show LRRFIP2 Proteins) and Flap-1/LRRFIP1 compete with Fliih (show FLII Proteins) for interacting with MyD88 (show MYD88 Proteins) to activate the signaling.
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
leucine rich repeat (in FLII) interacting protein 1
, leucine-rich repeat flightless-interacting protein 1-like
, FLAP (FLI LRR associated protein)
, FLI-LRR-associated protein 1
, H186 FLAP
, LRR FLII-interacting protein 1
, leucine-rich repeat flightless-interacting protein 1
, GC-binding factor 2
, NEDD8-conjugating enzyme
, TAR RNA-interacting protein