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May play important roles in cardiac development and/or cardiac function (By similarity). Additionally we are shipping LRRC10 Antibodies (5) and LRRC10 Proteins (5) and many more products for this protein.
This study firstly reports the association of LRRC10 mutations with enhanced susceptibility to dilated cardiomyopathy in humans.
LRRC10 is required to maintain cardiac performance in response to pressure overload and suggest that dysregulated expression or mutation of LRRC10
Data demonstrate that the transcription factors Nkx2-5 (show NKX2-5 ELISA Kits) and GATA4 (show GATA4 ELISA Kits) cooperatively regulate cardiac-specific expression of Lrrc10.
Lrrc10 is a novel dilated cardiomyopathy candidate gene and the Lrrc10-/- mouse model is a unique system to investigate pediatric cardiomyopathy.
GATA4 (show GATA4 ELISA Kits) and MEF2C (show MEF2C ELISA Kits) can both increase transcriptional activity of Lrrc10 promoter but that they do not work together in a synergistic fashion.
SERDIN1 is intimately integrated with the molecular pathways controlling cardiogenesis in vertebrates
LRRC10 exhibits dynamic intracellular expression patterns in cardiomyocytes.
Lrrc10-null mice develop normally and exhibit no discernable phenotype
May play important roles in cardiac development and/or cardiac function (By similarity).
leucine-rich repeat-containing protein 10
, heart-restricted leucine-rich repeat protein
, leucine-rich containing 10
, leucine-rich repeat protein
, leucine-rich repeat-containing 10