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LRRC32 encodes a type I membrane protein which contains 20 leucine-rich repeats. Additionally we are shipping LRRC32 Antibodies (23) and many more products for this protein.
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GARP (show CNGB1 Proteins) deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction.
since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb
GARP (show CNGB1 Proteins) is regulated by miRNAs and controls latent TGF-beta1 (show TGFB1 Proteins) production by human regulatory T cells.
we investigated in detail miR (show MLXIP Proteins)-142-3 pregulation of GARP (show CNGB1 Proteins) expression in regulatory CD25 (show IL2RA Proteins)(+) CD4 (show CD4 Proteins) T cells
Findings support the idea that GARP (show CNGB1 Proteins) is a new latent TGFbeta-binding protein that regulates the bioavailability of TGFbeta (show TGFB1 Proteins) and provides a cell surface platform for alphaV integrin (show ITGAV Proteins)-dependent TGFbeta (show TGFB1 Proteins) activation.
There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels
GARP (show CNGB1 Proteins) is a key receptor controlling FOXP3 (show FOXP3 Proteins) in T(reg (show EXTL3 Proteins)) cells following T-cell activation in a positive feedback loop assisted by LGALS3 (show LGALS3 Proteins) and LGMN (show LGMN Proteins)
the processing and expression of LRRC32
on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP (show CNGB1 Proteins)) associated with asthma risk
GARP (show CNGB1 Proteins) is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 (show FOXP3 Proteins) expression
These results demonstrate the unexpected presence of GARP on Hepatic stellate cells and its significance in regard to the ability of Hepatic stellate cells to activate latent TGF-beta1 (show TGFB1 Proteins) and thereby inhibit T cells.
GARP expression on MSCs contributed to their ability to inhibit T-cell responses in vitro.
We conclude that a missense mutation in VPS54, an essential component of the Golgi-associated retrograde protein complex, not only prevents the formation of an acrosome but also initiates a cascade of metabolic abnormalities and a stress reaction.
These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-beta (show TGFB1 Proteins) and signaling, which negatively regulates GARP expression on Tregs.
GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 (show FOXP3 Proteins) expression
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
leucine rich repeat containing 32
, leucine-rich repeat-containing protein 32
, leucine-rich repeat-containing protein 32-like
, glycoprotein A repetitions predominant