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LRRC32 encodes a type I membrane protein which contains 20 leucine-rich repeats. Additionally we are shipping LRRC32 Proteins (7) and LRRC32 Kits (1) and many more products for this protein.
Showing 10 out of 65 products:
Human Monoclonal LRRC32 Primary Antibody for ELISA, IP - ABIN4230471
Tran, Shevach: Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells. in Human immunology 2009
Show all 3 references for ABIN4230471
Human Polyclonal LRRC32 Primary Antibody for IHC (p), WB - ABIN453046
Maire, Forus, Foa, Bjerkehagen, Mainguené, Kresse, Myklebost, Pedeutour: 11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5. in Genes, chromosomes & cancer 2003
Human Monoclonal LRRC32 Primary Antibody for WB - ABIN1981876
Wang, Zhu, Dong, Shi, Lu, Springer: GARP regulates the bioavailability and activation of TGF?. in Molecular biology of the cell 2012
Human Polyclonal LRRC32 Primary Antibody for FACS, WB - ABIN4331580
Macaulay, Thon, Tijssen, Steele, MacDonald, Meade, Burns, Rendon, Salunkhe, Murphy, Bennett, Watkins, He, Fitzgerald, Italiano, Maguire: Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. in Blood 2013
LRRC32 expression is significantly upregulated in human masticatory mucosa during wound healing
GARP (show CNGB1 Antibodies) deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction.
since GARP (show CNGB1 Antibodies) functions as a transporter of transforming growth factor beta (TGFbeta (show TGFB1 Antibodies)), a cytokine with broad pleiotropic traits, GARP (show CNGB1 Antibodies) transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb (show TGFB1 Antibodies)
GARP (show CNGB1 Antibodies) is regulated by miRNAs and controls latent TGF-beta1 (show TGFB1 Antibodies) production by human regulatory T cells.
we investigated in detail miR (show MLXIP Antibodies)-142-3 pregulation of GARP (show CNGB1 Antibodies) expression in regulatory CD25 (show IL2RA Antibodies)(+) CD4 (show CD4 Antibodies) T cells
Findings support the idea that GARP (show CNGB1 Antibodies) is a new latent TGFbeta-binding protein (show LTBP1 Antibodies) that regulates the bioavailability of TGFbeta (show TGFB1 Antibodies) and provides a cell surface platform for alphaV integrin (show ITGAV Antibodies)-dependent TGFbeta (show TGFB1 Antibodies) activation.
There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels
GARP (show CNGB1 Antibodies) is a key receptor controlling FOXP3 (show FOXP3 Antibodies) in T(reg (show EXTL3 Antibodies)) cells following T-cell activation in a positive feedback loop assisted by LGALS3 (show LGALS3 Antibodies) and LGMN (show LGMN Antibodies)
the processing and expression of LRRC32
on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP (show CNGB1 Antibodies)) associated with asthma risk
These results demonstrate the unexpected presence of GARP on Hepatic stellate cells and its significance in regard to the ability of Hepatic stellate cells to activate latent TGF-beta1 (show TGFB1 Antibodies) and thereby inhibit T cells.
GARP expression on MSCs contributed to their ability to inhibit T-cell responses in vitro.
We conclude that a missense mutation in VPS54 (show VPS54 Antibodies), an essential component of the Golgi-associated retrograde protein complex, not only prevents the formation of an acrosome but also initiates a cascade of metabolic abnormalities and a stress reaction.
These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-beta (show TGFB1 Antibodies) and signaling, which negatively regulates GARP expression on Tregs.
GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 (show FOXP3 Antibodies) expression
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
leucine rich repeat containing 32
, leucine-rich repeat-containing protein 32
, leucine-rich repeat-containing protein 32-like
, glycoprotein A repetitions predominant