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LRRC8A encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. Additionally we are shipping LRRC8A Proteins (10) and many more products for this protein.
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Human Polyclonal LRRC8A Primary Antibody for WB - ABIN1881512
Conley: Genes required for B cell development. in The Journal of clinical investigation 2003
Show all 3 Pubmed References
Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (show INS Antibodies) sensitivity and glucose tolerance.
LRRC8 channels transport the neurotransmitters glutamate (show GRIN1 Antibodies), aspartate and gamma-aminobutyric acid (GABA) and the co-activator D-serine.
It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 (show SLC31A1 Antibodies) and LRRC8A protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A (show ATP7A Antibodies), ATP7B (show ATP7B Antibodies)), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.
LRRC8A is an essential regulator of cisplatin induced p53 (show TP53 Antibodies) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2 (show MDM2 Antibodies), as well as activation of caspase-9 (show CASP9 Antibodies) and -3 in tumor cell lines.
volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A
These data suggest that LRRC8A is associated with the deceleration mechanism of Volume-sensitive outwardly rectifying anion channel inactivation, while none of LRRC8 members is related to the acceleration mechanism.
Study identified SWELL1 (LRRC8A), a member of a four-transmembrane protein family with unknown function, as essential for hypotonicity-induced iodide influx. SWELL1 is localized to the plasma membrane, and its knockdown dramatically reduces endogenous volume-regulated anion channel currents and regulatory cell volume decrease in various cell types.
Genomic disruption of LRRC8A ablated volume-regulated anion channel (VRAC) currents. Cells with disruption of all five LRRC8 genes required LRRC8A cotransfection with other LRRC8 isoforms to reconstitute VRAC currents.
LRRC8 is required for B cell development.
identified four genes, named TA-LRRP, AD158 (show LRRC8C Antibodies), LRRC5, and FLJ23420, as unknown LRRC8-like genes
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
leucine-rich repeat-containing protein 8A
, leucine rich repeat containing 8A
, leucine-rich repeat-containing 8