anti-Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) Antibodies

LRRC8A encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. Additionally we are shipping LRRC8A Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LRRC8A 56262 Q8IWT6
LRRC8A 311846 Q4V8I7
LRRC8A 241296 Q80WG5
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Top anti-LRRC8A Antibodies at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-LRRC8A Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-LRRC8A Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:2500<br><b>Positive Control: </b>HT1080 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB LRRC8A Antibody (C-term) (ABIN1881512) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the LRRC8A antibody detected the LRRC8A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IP, WB Western Blot: LRRC8A Antibody [NBP2-32158] - LRRC8A Antibody [NBP2-32158] - Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-LRRC8A antibody NBP2-32158 used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. Immunoprecipitation: LRRC8A Antibody [NBP2-32158] - Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-LRRC8A antibody NBP2-32158 used for IP at 6 ug/mg lysate. For blotting immunoprecipitated LRRC8A, NBP2-32158 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$340.00
Details
Human Rabbit Un-conjugated WB LRRC8A antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
$473.93
Details
Human Rabbit Un-conjugated WB LRRC8A antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
$473.93
Details

LRRC8A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus) ,


Mouse (Murine) ,


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Top referenced anti-LRRC8A Antibodies

  1. Human Polyclonal LRRC8A Primary Antibody for WB - ABIN1881512 : Conley: Genes required for B cell development. in The Journal of clinical investigation 2003 (PubMed)
    Show all 3 Pubmed References

More Antibodies against LRRC8A Interaction Partners

Human Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) interaction partners

  1. Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (show INS Antibodies) sensitivity and glucose tolerance.

  2. LRRC8 channels transport the neurotransmitters glutamate (show GRIN1 Antibodies), aspartate and gamma-aminobutyric acid (GABA) and the co-activator D-serine.

  3. It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 (show SLC31A1 Antibodies) and LRRC8A protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A (show ATP7A Antibodies), ATP7B (show ATP7B Antibodies)), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.

  4. LRRC8A is an essential regulator of cisplatin induced p53 (show TP53 Antibodies) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2 (show MDM2 Antibodies), as well as activation of caspase-9 (show CASP9 Antibodies) and -3 in tumor cell lines.

  5. volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A

  6. These data suggest that LRRC8A is associated with the deceleration mechanism of Volume-sensitive outwardly rectifying anion channel inactivation, while none of LRRC8 members is related to the acceleration mechanism.

  7. Study identified SWELL1 (LRRC8A), a member of a four-transmembrane protein family with unknown function, as essential for hypotonicity-induced iodide influx. SWELL1 is localized to the plasma membrane, and its knockdown dramatically reduces endogenous volume-regulated anion channel currents and regulatory cell volume decrease in various cell types.

  8. Genomic disruption of LRRC8A ablated volume-regulated anion channel (VRAC) currents. Cells with disruption of all five LRRC8 genes required LRRC8A cotransfection with other LRRC8 isoforms to reconstitute VRAC currents.

  9. LRRC8 is required for B cell development.

  10. identified four genes, named TA-LRRP, AD158 (show LRRC8C Antibodies), LRRC5, and FLJ23420, as unknown LRRC8-like genes

Mouse (Murine) Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) interaction partners

  1. Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (show INS Antibodies) sensitivity and glucose tolerance.

  2. volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A

  3. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.

LRRC8A Antigen Profile

Protein Summary

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Gene names and symbols associated with LRRC8A

  • leucine rich repeat containing 8 family, member A (lrrc8a) antibody
  • leucine rich repeat containing 8 family, member A (LRRC8A) antibody
  • leucine rich repeat containing 8 family, member A (Lrrc8a) antibody
  • leucine rich repeat containing 8A (Lrrc8a) antibody
  • AGM5 antibody
  • LLRC8A antibody
  • Lrrc8 antibody
  • mKIAA1437 antibody
  • wu:fb18g12 antibody
  • wu:fi21b10 antibody

Protein level used designations for LRRC8A

leucine-rich repeat-containing protein 8A , leucine rich repeat containing 8A , leucine-rich repeat-containing 8

GENE ID SPECIES
327642 Danio rerio
494672 Xenopus laevis
417201 Gallus gallus
56262 Homo sapiens
491309 Canis lupus familiaris
505605 Bos taurus
311846 Rattus norvegicus
241296 Mus musculus
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