Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) ELISA Kits

LRRC8A encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. Additionally we are shipping LRRC8A Antibodies (52) and LRRC8A Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human LRRC8A LRRC8A 56262 Q8IWT6
Anti-Rat LRRC8A LRRC8A 311846 Q4V8I7
Anti-Mouse LRRC8A LRRC8A 241296 Q80WG5
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More ELISA Kits for LRRC8A Interaction Partners

Human Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) interaction partners

  1. Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (show INS ELISA Kits) sensitivity and glucose tolerance.

  2. LRRC8 channels transport the neurotransmitters glutamate (show GRIN1 ELISA Kits), aspartate and gamma-aminobutyric acid (GABA) and the co-activator D-serine.

  3. It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 (show SLC31A1 ELISA Kits) and LRRC8A protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A (show ATP7A ELISA Kits), ATP7B (show ATP7B ELISA Kits)), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.

  4. LRRC8A is an essential regulator of cisplatin induced p53 (show TP53 ELISA Kits) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2 (show MDM2 ELISA Kits), as well as activation of caspase-9 (show CASP9 ELISA Kits) and -3 in tumor cell lines.

  5. volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A

  6. These data suggest that LRRC8A is associated with the deceleration mechanism of Volume-sensitive outwardly rectifying anion channel inactivation, while none of LRRC8 members is related to the acceleration mechanism.

  7. Study identified SWELL1 (LRRC8A), a member of a four-transmembrane protein family with unknown function, as essential for hypotonicity-induced iodide influx. SWELL1 is localized to the plasma membrane, and its knockdown dramatically reduces endogenous volume-regulated anion channel currents and regulatory cell volume decrease in various cell types.

  8. Genomic disruption of LRRC8A ablated volume-regulated anion channel (VRAC) currents. Cells with disruption of all five LRRC8 genes required LRRC8A cotransfection with other LRRC8 isoforms to reconstitute VRAC currents.

  9. LRRC8 is required for B cell development.

  10. identified four genes, named TA-LRRP, AD158 (show LRRC8C ELISA Kits), LRRC5, and FLJ23420, as unknown LRRC8-like genes

Mouse (Murine) Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) interaction partners

  1. Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (show INS ELISA Kits) sensitivity and glucose tolerance.

  2. volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A

  3. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.

LRRC8A Antigen Profile

Antigen Summary

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Gene names and symbols associated with LRRC8A

  • leucine rich repeat containing 8 family, member A (lrrc8a) antibody
  • leucine rich repeat containing 8 family, member A (LRRC8A) antibody
  • leucine rich repeat containing 8 family, member A (Lrrc8a) antibody
  • leucine rich repeat containing 8A (Lrrc8a) antibody
  • AGM5 antibody
  • LLRC8A antibody
  • Lrrc8 antibody
  • mKIAA1437 antibody
  • wu:fb18g12 antibody
  • wu:fi21b10 antibody

Protein level used designations for LRRC8A

leucine-rich repeat-containing protein 8A , leucine rich repeat containing 8A , leucine-rich repeat-containing 8

GENE ID SPECIES
327642 Danio rerio
494672 Xenopus laevis
417201 Gallus gallus
56262 Homo sapiens
491309 Canis lupus familiaris
505605 Bos taurus
311846 Rattus norvegicus
241296 Mus musculus
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