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May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (By similarity). Additionally we are shipping LINGO1 Antibodies (123) and and many more products for this protein.
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LINGO1 rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA (show TPO Proteins), in Chinese population.
LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antibody and can carry antibody conjugated with drugs to kill Ewing sarcoma cells.
Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR (show RTN4R Proteins)) for binding to p75 neurotrophin receptor (p75NTR (show NGFR Proteins)).
The results of this study show Increased LINGO1 in the cerebellum of essential tremor patients.
Lingo-1 signaling is altered in the schizophrenia brain.
LINGO-1 can directly bind to ErbB2 (show ERBB2 Proteins), block ErbB2 (show ERBB2 Proteins) translocation into lipid rafts, and inhibit its phosphorylation.
This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor.
LINGO1 variants are associated with essential tremor in Chinese Han female patients.
LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.
Results of a meta-analysis suggest a relationship between LINGO1 rs11856808 polymorphism and risk of essential tremor (ET) and familial ET, while rs9652490 polymorphism is only associated with the risk for familial ET.
These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1
LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions
a novel role for LINGO-1 in neural stem cell differentiation to neurons
inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration
Lingo1 antagonist promotes spinal cord remyelination and axonal integrity in MOG (show MOG Proteins)-induced experimental autoimmune encephalomyelitis.
May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (By similarity).
leucine rich repeat and Ig domain containing 1
, leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
, leucine rich repeat neuronal 6A
, leucine-rich repeat and immunoglobilin domain-containing protein 1
, leucine-rich repeat and immunoglobulin domain-containing protein 1
, leucine-rich repeat neuronal protein 1
, leucine-rich repeat neuronal protein 6A
, leucine-rich repeat neuronal 6A