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LRSAM1 encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Additionally we are shipping LRSAM1 Proteins (6) and LRSAM1 Kits (2) and many more products for this protein.
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Human Polyclonal LRSAM1 Primary Antibody for EIA, IHC (p) - ABIN953239
Markson, Kiel, Hyde, Brown, Charalabous, Bremm, Semple, Woodsmith, Duley, Salehi-Ashtiani, Vidal, Komander, Serrano, Lehner, Sanderson: Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. in Genome research 2009
Show all 2 references for ABIN953239
Human Polyclonal LRSAM1 Primary Antibody for IHC, IHC (p) - ABIN4331719
Bogdanik, Sleigh, Tian, Samuels, Bedard, Seburn, Burgess: Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease. in Disease models & mechanisms 2013
Plant homeodomain finger protein 23 negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1
disruption of the C-terminal RING domain confers dominant negative properties to LRSAM1
Our data further confirms that LRSAM1 mutations are associated with CMT2 of AD inheritance.
Authors identify LRSAM1 as the E3 ligase responsible for anti-Salmonella autophagy-associated ubiquitination.
homozygous mutation in LRSAM1 was proposed as a strong candidate for the disease in a family with recessive axonal polyneuropathy
LRSAM1 as a component of the antibacterial autophagic response.
LRSAM1 is a strong candidate for the causal gene for the Charcot-Marie-Tooth disease.
Results suggest that RIFLE represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells [RIFLE protein].
Tal (show TALDO1 Antibodies) regulates a Tsg101 (show TSG101 Antibodies)-associated complex responsible for the sorting of cargo into cytoplasm-containing vesicles that bud at the multivesicular body and at the plasma membrane
Tal (show TALDO1 Antibodies) polyubiquitinates lysine residues in the C-terminus of uncomplexed Tsg101 (show TSG101 Antibodies), resulting in proteasomal degradation.
TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.
Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised.
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.
E3 ubiquitin-protein ligase LRSAM1
, Tsg101-associated ligase
, leucine-rich repeat and sterile alpha motif-containing protein 1
, tsg101-associated ligase