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Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Additionally we are shipping LZTS2 Antibodies (46) and LZTS2 Proteins (6) and many more products for this protein.
Lzts2 regulates gastrula CE movements, dorsoventral patterning, and midline convergence and specification of organ precursors through interaction with and the export of nuclear beta-catenins in zebrafish.
LZTS2 could inhibit cell proliferation and cell cycle transition at the G1/S phase and was implicated in the regulation of proteins associated with the canonical Wnt (show WNT2 ELISA Kits) pathway, including GSK3B (show GSK3b ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits) through inactivating the Akt (show AKT1 ELISA Kits) pathway.
deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development.
LZTS2 is a beta (show SUCLA2 ELISA Kits)-catenin-interacting protein (show CTNNBIP1 ELISA Kits) and modulates beta-catenin (show CTNNB1 ELISA Kits) signaling and localization
The reciprocal crosstalk between beta-catenin (show CTNNB1 ELISA Kits)/Tcf (show HNF4A ELISA Kits) pathway and NF-kappaB (show NFKB1 ELISA Kits) signaling in hMSCs is mediated through the regulation of lzts2 expression.
LAPSER1 C terminal domain inhibits katanin(p80 (show KATNB1 ELISA Kits)/p60)-mediated microtubule severing in vitro.
The data demonstrate the significance of simultaneous Pten and Lzts2 deletion in oncogenic transformation in prostate cells and implicates a new mechanism for the dysregulation of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling in prostate tumorigenesis.
a critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of beta-catenin (show CTNNB1 ELISA Kits)-mediated nephrogenesis.
Members of the ProSAP/Shank (show SHANK2 ELISA Kits) family and LAPSER1 not only play a role in postsynaptic density formation and plasticity, but also during embryonic development.
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin (By similarity).
leucine zipper putative tumor suppressor 2 homolog
, Protein lapser1
, leucine zipper, putative tumor suppressor 2
, leucine zipper putative tumor suppressor 2-like
, leucine zipper putative tumor suppressor 2
, putative tumor suppressor LAPSER1
, Protein LAPSER1
, protein lapser1