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LZTFL1 encodes a ubiquitously expressed protein that localizes to the cytoplasm. Additionally we are shipping Leucine Zipper Transcription Factor-Like 1 Antibodies (78) and Leucine Zipper Transcription Factor-Like 1 Proteins (9) and many more products for this protein.
these data indicate that LZTFL1 modulates T cell activation and IL-5 (show IL5 ELISA Kits) levels.
LZTFL1 binds beta-catenin (show CTNNB1 ELISA Kits) in the cytoplasm of the cell and inhibited its nuclear translocation
This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17).
The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17).
Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog (show SHH ELISA Kits) signaling
LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin (show CDH1 ELISA Kits)-mediated adherens junction formation and promoting epithelial cell differentiation.
the expression levels of leucine zipper transcription factor-like protein 1 (Lztfl1) mRNA were significantly higher in SAMP8 mice subjected to exercise training.
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome\; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor\; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.
leucine zipper transcription factor-like 1
, Leucine zipper transcription factor-like protein 1
, leucine zipper transcription factor-like protein 1