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anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) Antibodies

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Additionally we are shipping LGR4 Kits (14) and LGR4 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LGR4 55366 Q9BXB1
LGR4 107515 A2ARI4
LGR4 286994 Q9Z2H4
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Top anti-LGR4 Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chimpanzee Mouse Un-conjugated EIA, IHC (p), WB 25 μL Log in to see 6 to 8 Days
$253.00
Details
Human Mouse Un-conjugated IHC, ELISA, WB anti-LGR4 monoclonal antibody was used diluted to 5 ?g/ml to detect LGR4 staining at the membrane of cells in various human tissues. A. Brain cerebellum. B. Pancreas islet. Strongly positive staining is noted in subsets of cells within the islets of Langerhans. Moderately positive staiing was observed in Purkinje and Golgi neurons of the cerebellum, adrenal medulla, neuroendocrine cells, hepatocytes, lung macrophages, seminiferous tubules and Leydig cells of the testis. Faintly to moderately positive staining was also observed in cardiac myocytes and renal tubules, granulocytes, and subsets of lymphocytes. Some elastin background staining is noted. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. 25 μL Log in to see 2 to 3 Days
$135.00
Details
Human HOST_Rat (Rattus) Un-conjugated cELISA, FACS FACS analysis of BOSC23 cells using BBX-3A8. BOSC23 cells were transiently transfected with an expres-sion vector encoding either LGR4-hum (red curve), LGR4-murine (blue curve) or an irrelevant protein (control transfectant: black curve). Binding of BBX-3A8 was detected with a PE-conjugated secondary antibody. A positive signal was obtained with LGR4- hum and LGR4-mur transfected cells. SDS-PAGE analysis of purified BBX-3A8 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 μg of purified BBX-3A8 antibody. Proteins were separated by SDS-PAGE and stained with RAPID StainTM Reagent. 100 μg Log in to see 5 to 6 Days
$386.93
Details
Human HOST_Rat (Rattus) Un-conjugated cELISA, FACS FACS analysis of BOSC23 cells using BBX-1H1 (ABIN1720913). BOSC23 cells were transiently transfected with an expres-sion vector encoding either LGR4-hum (red curve), LGR4-murine (blue curve) or an irrelevant protein (control transfectant: black curve). Binding of BBX-3A8 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with LGR4-hum transfected cells. SDS-PAGE analysis of purified BBX-1H1 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 μg of purified BBX-1H1 antibody. Proteins were separated by SDS-PAGE and stained with RAPID StainTM Reagent. 100 μg Log in to see 5 to 6 Days
$386.93
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Lgr4/GPR48 Antibody [NBP1-89737] - Staining of human breast shows strong positivity in glandular cells. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: Lgr4/GPR48 Antibody [NLS1631] - Analysis of anti-GPR48 / LGR4 antibody with human brain, glioblastoma. Immunohistochemistry-Paraffin: Lgr4/GPR48 Antibody [NLS1631] - Analysis of anti-GPR48 / LGR4 antibody with human brain neurons. 0.05 mL Log in to see 8 to 11 Days
$447.56
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC221345 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LGR4 antibody (ABIN2454807), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LGR4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR4. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of Brain (Neurons and glia) using anti- LGR4 antibody ABIN122159 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells, using LGR4 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded HSC3 xenograft, using LGR4, antibody at 1:250 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details

LGR4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LGR4 Antibodies

  1. Chimpanzee Monoclonal LGR4 Primary Antibody for EIA, IHC (p) - ABIN400823 : Weng, Luo, Cheng, Jin, Zhou, Qu, Tu, Ai, Li, Wang, Martin, Amendt, Liu: Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 4 references for ABIN400823

  2. Human Monoclonal LGR4 Primary Antibody for cELISA, FACS - ABIN1720913 : Loh, Broussard, Liu, Copeland, Gilbert, Jenkins, Kolakowski: Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping. in Cytogenetics and cell genetics 2000 (PubMed)
    Show all 3 references for ABIN1720913

  3. Human Monoclonal LGR4 Primary Antibody for cELISA, FACS - ABIN1381741 : Loh, Broussard, Kolakowski: Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. in Biochemical and biophysical research communications 2001 (PubMed)
    Show all 2 references for ABIN1381741

  4. Human Polyclonal LGR4 Primary Antibody for IHC (p) - ABIN4330842 : Shannon: IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells. in International journal of cell biology 2012 (PubMed)

  5. Human Polyclonal LGR4 Primary Antibody for IHC, IHC (p) - ABIN4330846 : Steffen, Simon, Warneke, Balschun, Ebert, Röcken: LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma. in Virchows Archiv : an international journal of pathology 2012 (PubMed)

More Antibodies against LGR4 Interaction Partners

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) interaction partners

  1. A mechanistic understanding of RANKL (show TNFSF11 Antibodies)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Antibodies) signaling in osteoporosis and other diseases

  2. miR (show MLXIP Antibodies)-218 directly targets LGR4 and modulated the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways in the LNCaP-IL-6 (show IL6 Antibodies)+ cells.

  3. LGR4 promotes tumorigenesis of prostate cancer via PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway.

  4. These findings suggest that aberrant RSPO3 (show RSPO3 Antibodies)-LGR4 signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (show KEAP1 Antibodies)-deficient lung ADs (show AGPS Antibodies).

  5. the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors

  6. our results suggest a previously unknown Stat3 (show STAT3 Antibodies)-LGR4 molecular network, which may control osteosarcoma development and progression

  7. RSPO (show RSPO1 Antibodies)-LGR4 not only induces the clearance of RNF43 (show RNF43 Antibodies)/ZNRF3 (show ZNRF3 Antibodies) to increase Wnt receptor levels but also recruits IQGAP1 (show IQGAP1 Antibodies) into the Wnt (show WNT2 Antibodies) signaling complex.

  8. Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR (show AGRN Antibodies) syndrome

  9. GPR48 overexpression promotes cancer cell proliferation via activation of Wnt (show WNT2 Antibodies) signaling.

  10. Lgr4 overexpression promoted glioma cell proliferation through activation of Wnt (show WNT2 Antibodies) signaling.

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) interaction partners

  1. Study suggests that miR (show MLXIP Antibodies)-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation.

  2. A mechanistic understanding of RANKL (show TNFSF11 Antibodies)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Antibodies) signaling in osteoporosis and other diseases

  3. LGR4 acted as a key receptor for Rspo2 (show RSPO2 Antibodies) to promote osteogenesis.

  4. Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 (show RSPO1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)

  5. results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging.

  6. The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP Antibodies)-mediated Lgr4-Wnt (show WNT2 Antibodies) signaling during gonadal development.

  7. suggests that Lgr4 might serve as an adaptive regulator between glucose and lipid metabolism in skeletal muscle and reveals a potentially new regulator for a well-established adaptive network

  8. An important role for Lgr4 in motor coordination and cerebellar synaptic plasticity.

  9. formation of polycystic lesions and renal fibrosis induced by Gpr48 deficiency involves the activation of Wnt (show WNT2 Antibodies) signaling pathway but not the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) pathway

  10. The members of the R-spondin family are known as activators of Wnt (show WNT2 Antibodies) signaling, and Lgr4, Lgr5 (show LGR5 Antibodies), and Lgr6 (show LGR6 Antibodies) have been identified as receptors for R-spondins.

LGR4 Antigen Profile

Protein Summary

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008

Gene names and symbols associated with LGR4

  • leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) antibody
  • leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) antibody
  • 9130225G07 antibody
  • A330106J01Rik antibody
  • A930009A08Rik antibody
  • BNMD17 antibody
  • Gpr48 antibody

Protein level used designations for LGR4

G protein-coupled receptor 48 , leucine-rich repeat-containing G-protein coupled receptor 4 , G protein-coupled receptor GPR48 , G-protein coupled receptor 48

GENE ID SPECIES
55366 Homo sapiens
451088 Pan troglodytes
107515 Mus musculus
286994 Rattus norvegicus
Selected quality suppliers for anti-LGR4 (LGR4) Antibodies
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