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G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Additionally we are shipping LGR4 Kits (14) and LGR4 Proteins (7) and many more products for this protein.
Showing 10 out of 79 products:
Chimpanzee Monoclonal LGR4 Primary Antibody for EIA, IHC (p) - ABIN400823
Weng, Luo, Cheng, Jin, Zhou, Qu, Tu, Ai, Li, Wang, Martin, Amendt, Liu: Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 4 references for ABIN400823
Human Monoclonal LGR4 Primary Antibody for cELISA, FACS - ABIN1720913
Loh, Broussard, Liu, Copeland, Gilbert, Jenkins, Kolakowski: Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping. in Cytogenetics and cell genetics 2000
Show all 3 references for ABIN1720913
Human Monoclonal LGR4 Primary Antibody for cELISA, FACS - ABIN1381741
Loh, Broussard, Kolakowski: Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. in Biochemical and biophysical research communications 2001
Show all 2 references for ABIN1381741
Human Polyclonal LGR4 Primary Antibody for IHC (p) - ABIN4330842
Shannon: IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells. in International journal of cell biology 2012
Human Polyclonal LGR4 Primary Antibody for IHC, IHC (p) - ABIN4330846
Steffen, Simon, Warneke, Balschun, Ebert, Röcken: LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma. in Virchows Archiv : an international journal of pathology 2012
A mechanistic understanding of RANKL (show TNFSF11 Antibodies)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Antibodies) signaling in osteoporosis and other diseases
miR (show MLXIP Antibodies)-218 directly targets LGR4 and modulated the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways in the LNCaP-IL-6 (show IL6 Antibodies)+ cells.
LGR4 promotes tumorigenesis of prostate cancer via PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway.
These findings suggest that aberrant RSPO3 (show RSPO3 Antibodies)-LGR4 signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (show KEAP1 Antibodies)-deficient lung ADs (show AGPS Antibodies).
the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors
our results suggest a previously unknown Stat3 (show STAT3 Antibodies)-LGR4 molecular network, which may control osteosarcoma development and progression
RSPO (show RSPO1 Antibodies)-LGR4 not only induces the clearance of RNF43 (show RNF43 Antibodies)/ZNRF3 (show ZNRF3 Antibodies) to increase Wnt receptor levels but also recruits IQGAP1 (show IQGAP1 Antibodies) into the Wnt (show WNT2 Antibodies) signaling complex.
Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR (show AGRN Antibodies) syndrome
GPR48 overexpression promotes cancer cell proliferation via activation of Wnt (show WNT2 Antibodies) signaling.
Lgr4 overexpression promoted glioma cell proliferation through activation of Wnt (show WNT2 Antibodies) signaling.
Study suggests that miR (show MLXIP Antibodies)-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation.
LGR4 acted as a key receptor for Rspo2 (show RSPO2 Antibodies) to promote osteogenesis.
Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 (show RSPO1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)
results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging.
The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP Antibodies)-mediated Lgr4-Wnt (show WNT2 Antibodies) signaling during gonadal development.
suggests that Lgr4 might serve as an adaptive regulator between glucose and lipid metabolism in skeletal muscle and reveals a potentially new regulator for a well-established adaptive network
An important role for Lgr4 in motor coordination and cerebellar synaptic plasticity.
formation of polycystic lesions and renal fibrosis induced by Gpr48 deficiency involves the activation of Wnt (show WNT2 Antibodies) signaling pathway but not the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) pathway
The members of the R-spondin family are known as activators of Wnt (show WNT2 Antibodies) signaling, and Lgr4, Lgr5 (show LGR5 Antibodies), and Lgr6 (show LGR6 Antibodies) have been identified as receptors for R-spondins.
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008
G protein-coupled receptor 48
, leucine-rich repeat-containing G-protein coupled receptor 4
, G protein-coupled receptor GPR48
, G-protein coupled receptor 48