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G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Additionally we are shipping LGR4 Kits (15) and LGR4 Proteins (7) and many more products for this protein.
Showing 10 out of 62 products:
Chimpanzee Monoclonal LGR4 Primary Antibody for EIA, IHC (p) - ABIN400823
Weng, Luo, Cheng, Jin, Zhou, Qu, Tu, Ai, Li, Wang, Martin, Amendt, Liu: Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 4 references for ABIN400823
Human Monoclonal LGR4 Primary Antibody for cELISA, FACS - ABIN1720913
Loh, Broussard, Liu, Copeland, Gilbert, Jenkins, Kolakowski: Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping. in Cytogenetics and cell genetics 2000
Show all 3 references for ABIN1720913
Human Monoclonal LGR4 Primary Antibody for cELISA, FACS - ABIN1381741
Loh, Broussard, Kolakowski: Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. in Biochemical and biophysical research communications 2001
Show all 2 references for ABIN1381741
LGR4 promotes tumorigenesis of prostate cancer via PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway.
These findings suggest that aberrant RSPO3 (show RSPO3 Antibodies)-LGR4 signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (show KEAP1 Antibodies)-deficient lung ADs (show AGPS Antibodies).
the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors
our results suggest a previously unknown Stat3 (show STAT3 Antibodies)-LGR4 molecular network, which may control osteosarcoma development and progression
RSPO (show RSPO1 Antibodies)-LGR4 not only induces the clearance of RNF43 (show RNF43 Antibodies)/ZNRF3 (show ZNRF3 Antibodies) to increase Wnt receptor levels but also recruits IQGAP1 (show IQGAP1 Antibodies) into the Wnt (show WNT2 Antibodies) signaling complex.
Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR (show AGRN Antibodies) syndrome
GPR48 overexpression promotes cancer cell proliferation via activation of Wnt (show WNT2 Antibodies) signaling.
Lgr4 overexpression promoted glioma cell proliferation through activation of Wnt (show WNT2 Antibodies) signaling.
Upregulation of GPR48 resulted in increased phosphorylation of glycogen synthase kinase 3beta.
A functional low-frequency human LGR4 variant (A750T) has been associated with body mass index in a Chinese obese-versus-control study.
Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 (show RSPO1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)
results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging.
The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP Antibodies)-mediated Lgr4-Wnt (show WNT2 Antibodies) signaling during gonadal development.
suggests that Lgr4 might serve as an adaptive regulator between glucose and lipid metabolism in skeletal muscle and reveals a potentially new regulator for a well-established adaptive network
An important role for Lgr4 in motor coordination and cerebellar synaptic plasticity.
formation of polycystic lesions and renal fibrosis induced by Gpr48 deficiency involves the activation of Wnt (show WNT2 Antibodies) signaling pathway but not the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) pathway
The members of the R-spondin family are known as activators of Wnt (show WNT2 Antibodies) signaling, and Lgr4, Lgr5 (show LGR5 Antibodies), and Lgr6 (show LGR6 Antibodies) have been identified as receptors for R-spondins.
Lgr4 regulates corpus luteum maturation through modulation of the WNT (show WNT2 Antibodies)-mediated EGFR (show EGFR Antibodies)-ERK (show EPHB2 Antibodies) signaling pathway.
LGR4 plays an important role in the regulation of plasma lipid rhythms, partially through regulating the expression of microsomal triglyceride transfer protein (show MTTP Antibodies); these data provide a possible link between the peripheral circadian clock and lipid metabolism
data revealed the roles of Lgr4 in early prostate development and in stem cell differentiation through regulation of the Wnt (show WNT2 Antibodies), Notch (show NOTCH1 Antibodies), and Sonic Hedgehog (show SHH Antibodies) signaling pathways.
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008
G protein-coupled receptor 48
, leucine-rich repeat-containing G-protein coupled receptor 4
, G protein-coupled receptor GPR48
, G-protein coupled receptor 48