You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Antibodies

Orphan receptor. Additionally we are shipping LGR5 Proteins (6) and LGR5 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LGR5 14160 Q9Z1P4
LGR5 299802  
LGR5 8549 O75473
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-LGR5 Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of anti-LGR5/GPR49 Antibody (Center) (ABIN389219) in K562 cell line lysates (35 µg/lane). LGR5/GPR49(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (Center) (ABIN389219), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB Anti-LGR5 mouse monoclonal antibody ABIN2454875 immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5 (RC212845). HEK293T cells were transfected with the empty vector control (Left lane) or Human LGR5 expression plasmid (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR5. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB LGR5/GPR49 Antibody (Loop2) (ABIN389218) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Western blot analysis of anti-LGR5/GPR49 Antibody (loop2) (ABIN389218) in mouse cerebellum tissue lysates (35 µg/lane).LGR5/GPR49(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (loop1) (ABIN389217), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. LGR5/GPR49 Antibody (loop1) (ABIN389217) western blot analysis in HL-60 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB LGR5/GPR49 Antibody (N-term) (ABIN389215) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (N-term) (ABIN389215), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$253.00
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC212825 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LGR5 antibody (ABIN2454608), and then analyzed by flow cytometry. Anti-LGR5 mouse monoclonal antibody (ABIN2454608) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5 (RC212825). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LGR5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR5. 100 μL Log in to see 2 to 3 Days
$423.50
Details

LGR5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , , ,
, ,
,
Rat (Rattus) ,


Human , , , ,
, ,
,
, , , ,

Top referenced anti-LGR5 Antibodies

  1. Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389218 : Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters, Clevers: Identification of stem cells in small intestine and colon by marker gene Lgr5. in Nature 2007 (PubMed)
    Show all 11 references for ABIN389218

  2. Human Monoclonal LGR5 Primary Antibody for FACS, IF - ABIN2454875 : Wu, Xie, Gao, Wang, Guo, Tian, Li, Fan: Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. in Gene 2013 (PubMed)
    Show all 7 references for ABIN2454875

  3. Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389215 : Kanwar, Yu, Nautiyal, Patel, Majumdar: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. in Molecular cancer 2010 (PubMed)
    Show all 4 references for ABIN389215

  4. Human Polyclonal LGR5 Primary Antibody for EIA, IHC (p) - ABIN357894 : Yamamoto, Sakamoto, Fujii, Tsuiji, Kenetaka, Asaka, Hirohashi: Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. in Hepatology (Baltimore, Md.) 2003 (PubMed)
    Show all 4 references for ABIN357894

  5. Human Polyclonal LGR5 Primary Antibody for WB - ABIN871759 : Becker, Huang, Mashimo: Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. in TheScientificWorldJournal 2008 (PubMed)
    Show all 3 references for ABIN871759

  6. Human Polyclonal LGR5 Primary Antibody for FACS, IHC (p) - ABIN389219 : Walker, Zhang, Odorizzi, Burgess: LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. in PLoS ONE 2011 (PubMed)
    Show all 3 references for ABIN389219

  7. Human Polyclonal LGR5 Primary Antibody for EIA, FACS - ABIN357893 : McClanahan, Koseoglu, Smith, Grein, Gustafson, Black, Kirschmeier, Samatar: Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. in Cancer biology & therapy 2006 (PubMed)
    Show all 2 references for ABIN357893

More Antibodies against LGR5 Interaction Partners

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

  2. The generation of new retinal cells, including retinal neurons and Muller glia from Lgr5-expressed amacrine cells, begins in early adulthood and continues as the animal ages.

  3. Endogenous hyaluronic acid increases Lgr5(+) stem cell proliferation, crypt fission, and intestinal lengthening and that these effects are dependent on signaling through CD44 (show CD44 Antibodies) and TLR4 (show TLR4 Antibodies).

  4. Myh9 (show MYH9 Antibodies) mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells

  5. Lgr6 (show LGR6 Antibodies) and Bmi1 (show BMI1 Antibodies) have roles in stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis, while Lgr5 has a role in rapid cycling and maintance of sweat glands only

  6. H pylori colonize and manipulate the progenitor and Lgr5(+)stem cell compartments, which alters turnover kinetics and glandular hyperplasia.

  7. These data suggest that the neonatal mammalian cochlea has some capacity for hair cell regeneration following damage alone and that Lgr5-positive cells act as hair cell progenitors in the cochlea.

  8. Positioning within the niche and levels of LGR5 expression discriminate intestinal intestinal stem and progenitor cells with different Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling activity.

  9. Organoids that continue to express Lgr5 are multipotent.all three Lgr transcripts Lgr4 (show LGR4 Antibodies)-Lgr6 (show LGR6 Antibodies) were detected in sorted Lgr5+ cells from posterior tongue and in sorted Lgr6 (show LGR6 Antibodies)+ cells from either posterior or anterior tongue.

  10. The members of the R-spondin family are known as activators of Wnt (show WNT2 Antibodies) signaling, and Lgr4 (show LGR4 Antibodies), Lgr5, and Lgr6 (show LGR6 Antibodies) have been identified as receptors for R-spondins.

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

  2. Lgr5 overexpression was significantly associated with deep invasion of colorectal cancer lymphnode metastasis, distant metastasis and AJCC stage

  3. Data suggest that targeting of leucine rich repeat containing G protein-coupled receptor 5 (LGR5) may be of therapeutic benefit for neuroblastomas.

  4. This study shows that Lgr5 can be a valuable and reliable prognostic factor of colorectal cancer progression.

  5. We conclude that overexpression of LGR5 is associated with markers of tumor aggressiveness in human papillary thyroid cancer

  6. The results suggest that trichosanthin may induce apoptosis in glioma cells by targeting LGR5 and repressing the Wnt (show WNT2 Antibodies)/betabcatenin signaling pathway

  7. These findings indicate that LGR5 not only participates in carcinogenesis but also maintained stemness by activating Wnt/b-catenin signaling in breast cancer.

  8. We confirmed in a large and independent study cohort that LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-FU-based adjuvant chemotherapy.

  9. lgr5 methylation, through the regulation of lgr5 expression and colorectal CSC differentiation, may constitute a novel prognostic marker for colorectal cancer patients.

  10. High resolution crystal structure of an ectodomain variant of human LGR5 (hLGR5ecto) complexed with a signalling competent fragment of mouse Rspo2 (show RSPO2 Antibodies).

LGR5 Antigen Profile

Protein Summary

Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.

Gene names and symbols associated with LGR5

  • leucine-rich repeat containing G protein-coupled receptor 5 (lgr5) antibody
  • leucine rich repeat containing G protein coupled receptor 5 (Lgr5) antibody
  • leucine-rich repeat containing G protein-coupled receptor 5 (LGR5) antibody
  • FEX antibody
  • GPR49 antibody
  • GPR67 antibody
  • GRP49 antibody
  • HG38 antibody
  • lgr5-a antibody
  • lgr5a antibody

Protein level used designations for LGR5

leucine-rich repeat-containing G protein-coupled receptor 5 , leucine-rich repeat-containing G-protein coupled receptor 5A , leucine-rich repeat-containing G-protein coupled receptor 5a , G protein-coupled receptor 49 , G-protein coupled receptor 49 , follicle expressed hormone , leucine-rich repeat-containing G-protein coupled receptor 5 , orphan G-protein coupled receptor FEX , G-protein coupled receptor 67 , G-protein coupled receptor HG38 , orphan G protein-coupled receptor HG38

GENE ID SPECIES
100526795 Xenopus laevis
14160 Mus musculus
299802 Rattus norvegicus
8549 Homo sapiens
427867 Gallus gallus
Selected quality suppliers for anti-LGR5 (LGR5) Antibodies
Did you look for something else?