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Orphan receptor. Additionally we are shipping LGR5 Proteins (9) and LGR5 Kits (3) and many more products for this protein.
Showing 10 out of 182 products:
Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389218
Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters, Clevers: Identification of stem cells in small intestine and colon by marker gene Lgr5. in Nature 2007
Show all 11 references for ABIN389218
Human Monoclonal LGR5 Primary Antibody for FACS, IF - ABIN2454875
Wu, Xie, Gao, Wang, Guo, Tian, Li, Fan: Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. in Gene 2013
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Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389215
Kanwar, Yu, Nautiyal, Patel, Majumdar: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. in Molecular cancer 2010
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Human Polyclonal LGR5 Primary Antibody for EIA, IHC (p) - ABIN357894
Yamamoto, Sakamoto, Fujii, Tsuiji, Kenetaka, Asaka, Hirohashi: Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. in Hepatology (Baltimore, Md.) 2003
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Human Polyclonal LGR5 Primary Antibody for IHC, IHC (fro) - ABIN440586
Jung, Saif: Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. in Veterinary journal (London, England : 1997) 2015
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Human Polyclonal LGR5 Primary Antibody for FACS, IHC (p) - ABIN389219
Walker, Zhang, Odorizzi, Burgess: LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. in PLoS ONE 2011
Show all 3 references for ABIN389219
Human Polyclonal LGR5 Primary Antibody for EIA, FACS - ABIN357893
McClanahan, Koseoglu, Smith, Grein, Gustafson, Black, Kirschmeier, Samatar: Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. in Cancer biology & therapy 2006
Show all 2 references for ABIN357893
Human Polyclonal LGR5 Primary Antibody for IHC (p) - ABIN4330855
Chen, Chen, Chien, Wu, Ho, Yu, Chang: Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury. in PLoS ONE 2015
Human Polyclonal LGR5 Primary Antibody for IF (p), IHC (p) - ABIN737916
Su, Li, Liu, Ren, Tian, Liu, Qiu: Ionizing radiation promotes advanced malignant traits in nasopharyngeal carcinoma via activation of epithelial-mesenchymal transition and the cancer stem cell phenotype. in Oncology reports 2016
Our studies show for the first time that Lgr5 is expressed in the NC cells at embryonic day 9.5 (E9.5) and is maintained during embryonic development and postnataly in the stroma of the ventral tongue, and some areas of the oral mucosa and that Lgr5+ cells participate in the maintenance of the stroma.
Genetic fate-mapping of Alkaline phosphate intestinal(+) cells before or during targeted ablation of Lgr5-expressing stem cells generated numerous long-lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte precursors into Lgr5(+) stems.
Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.
The generation of new retinal cells, including retinal neurons and Muller glia from Lgr5-expressed amacrine cells, begins in early adulthood and continues as the animal ages.
Endogenous hyaluronic acid increases Lgr5(+) stem cell proliferation, crypt fission, and intestinal lengthening and that these effects are dependent on signaling through CD44 (show CD44 Antibodies) and TLR4 (show TLR4 Antibodies).
Myh9 (show MYH9 Antibodies) mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells
Lgr6 (show LGR6 Antibodies) and Bmi1 (show BMI1 Antibodies) have roles in stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis, while Lgr5 has a role in rapid cycling and maintance of sweat glands only
H pylori colonize and manipulate the progenitor and Lgr5(+)stem cell compartments, which alters turnover kinetics and glandular hyperplasia.
These data suggest that the neonatal mammalian cochlea has some capacity for hair cell regeneration following damage alone and that Lgr5-positive cells act as hair cell progenitors in the cochlea.
Positioning within the niche and levels of LGR5 expression discriminate intestinal intestinal stem and progenitor cells with different Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling activity.
High LGR5 expression is associated with colorectal cancer.
Lgr5 overexpression was significantly associated with deep invasion of colorectal cancer lymphnode metastasis, distant metastasis and AJCC stage
Data suggest that targeting of leucine rich repeat containing G protein-coupled receptor 5 (LGR5) may be of therapeutic benefit for neuroblastomas.
This study shows that Lgr5 can be a valuable and reliable prognostic factor of colorectal cancer progression.
We conclude that overexpression of LGR5 is associated with markers of tumor aggressiveness in human papillary thyroid cancer
The results suggest that trichosanthin may induce apoptosis in glioma cells by targeting LGR5 and repressing the Wnt (show WNT2 Antibodies)/betabcatenin signaling pathway
These findings indicate that LGR5 not only participates in carcinogenesis but also maintained stemness by activating Wnt/b-catenin signaling in breast cancer.
We confirmed in a large and independent study cohort that LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-FU-based adjuvant chemotherapy.
lgr5 methylation, through the regulation of lgr5 expression and colorectal CSC differentiation, may constitute a novel prognostic marker for colorectal cancer patients.
Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.
leucine-rich repeat-containing G protein-coupled receptor 5
, leucine-rich repeat-containing G-protein coupled receptor 5A
, leucine-rich repeat-containing G-protein coupled receptor 5a
, G protein-coupled receptor 49
, G-protein coupled receptor 49
, follicle expressed hormone
, leucine-rich repeat-containing G-protein coupled receptor 5
, orphan G-protein coupled receptor FEX
, G-protein coupled receptor 67
, G-protein coupled receptor HG38
, orphan G protein-coupled receptor HG38