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May participate in the regulation of neuronal exocytosis (By similarity). Additionally we are shipping Leucine-Rich Repeat LGI Family, Member 3 Antibodies (57) and Leucine-Rich Repeat LGI Family, Member 3 Kits (8) and many more products for this protein.
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LGI3 was mostly expressed in the granular layer of the epidermis of human skin.
findings show LGI3 and TNF-alpha (show TNF Proteins) upregulated each other in 3T3-L1 cells; study suggests LGI3 is a pro-inflammatory adipokine and forms a positive feedback loop with TNF-alpha (show TNF Proteins); propose that LGI3 is a member of adipokine network that plays regulatory roles in obesity-associated adipose tissue inflammation
results suggested that LGI3 may participate in adipose tissue homeostasis by negatively regulating adiponectin (show ADIPOQ Proteins)
Data suggest that leucine-rich glioma inactivated 3 (LGI3) may be a candidate adipokine that is perturbed in obesity and suppresses adipogenesis through its receptor, ADAM23 (show Adam23 Proteins).
LGI3 interacts with Flo1 in the brain, and LGI3/Flo1 mediates APP (show APP Proteins) trafficking and exosome formation in neuronal cells: reveals the details of the intracellular transport system and even the secretion pathway in the brain.
we propose that LGI3 is a neuritogenic factor whose signaling pathway involves Akt (show AKT1 Proteins)-mediated FAK (show PTK2 Proteins) activation.
LGI3 gene widespread expression in the brain suggests that its transcripts might be involved in a common cellular process present in different neuronal types.
The expression of mouse LGI3 (mLGI3) in adult and developing brain and analyzed the 5'-upstream transcriptional regulatory regions of mLGI3 gene.
Data show that LGI3 localizes to the endocytic pathway and its accumulation is caused by endocytic perturbation.
LGI3 may play a regulatory role in neuronal exocytosis via its interaction with syntaxin 1 (show STX1A Proteins).
May participate in the regulation of neuronal exocytosis (By similarity).
leucine-rich repeat LGI family member 3
, LGI1-like protein 4
, leucine-rich glioma-inactivated protein 3
, putative leucine-rich glioma inactivated 3