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anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) Antibodies

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).. Additionally we are shipping Lrig1 Proteins (10) and Lrig1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Lrig1 26018 Q96JA1
Lrig1 16206 P70193
Lrig1 312574  
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Top anti-Lrig1 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western Blot has been done using: The COS-7 cells transfected with expression vectors encoding LRIG1 (line 1) or LRIG2 (Line 2) and ZR-75, a breast carcinoma cell line (Line 3). Loading: 0.5 microgram of COS-7 lysates and 10 microgram of ZR-75 lysate. 50 μg Log in to see 5 to 6 Days
$375.38
Details
Mouse Rabbit Un-conjugated WB LRIG1 Antibody (C-term) (ABIN1881506) western blot analysis in mouse stomach tissue lysates (35 µg/lane). This demonstrates the LRIG1 antibody detected the LRIG1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Chicken Un-conjugated WB   200 μg Log in to see 5 to 6 Days
$604.07
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-LRIG1 Polyclonal Antibody, Unconjugated (ABIN735263) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Lane 1: mouse brain lysates Lane 2: mouse embryo lysates probed with Anti LRIG1 Polyclonal Antibody, Unconjugated (ABIN735263) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 120kD. Observed band size: 120kD. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

Lrig1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Lrig1 Antibodies

  1. Human Polyclonal Lrig1 Primary Antibody for WB - ABIN3197485 : Ledda, Bieraugel, Fard, Vilar, Paratcha: Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 (PubMed)
    Show all 6 references for ABIN3197485

  2. Mouse (Murine) Polyclonal Lrig1 Primary Antibody for WB - ABIN1881506 : Ye, Gao, Xu, Zeng, Ou, Mao, Wang, He, Wang, Yang, Guo, Lei: Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity. in Journal of neuro-oncology 2009 (PubMed)
    Show all 2 references for ABIN1881506

More Antibodies against Lrig1 Interaction Partners

Human Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) interaction partners

  1. ERa-dependent expression of LRIG1 dampens ErbB3 (show ERBB3 Antibodies) signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 (show ERBB3 Antibodies) accumulation, enhanced ErbB3 (show ERBB3 Antibodies) signaling to cell survival pathways

  2. These findings demonstrate that LRIG1 is an independent prognostic factor in patients with non-small cell lung cancer

  3. LRIG1 expression was associated with pathological type, differentiation status, and stage of Non-small Cell Lung Cancer. The result showed that LRIG1 was an independent prognostic factor for OS of NSCLC patients.

  4. The inhibitory effects of LRIG1 are most likely mediated by suppression of the EGFR (show EGFR Antibodies)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway and epithelial-mesenchymal transition (EMT (show ITK Antibodies)) process.

  5. LRIG1 can enhance chemosensitivity in glioblastoma by inhibition of BCL-2 (show BCL2 Antibodies) and MnSOD (show SOD2 Antibodies)

  6. Results showed that leucine-rich repeats and immunoglobulin-like domains can reverse multidrug resistance in glioblastoma, by negatively regulating epidermal growth factor receptor (show EGFR Antibodies).

  7. MiR (show MLXIP Antibodies)-20a mediated temozolomide-resistance in glioblastoma cells through negatively regulating LRIG1 expression.

  8. Based on these results, we concluded that the upregulation of LRIG1 expression inhibited the EGFR (show EGFR Antibodies) signaling pathway, activated the mitochondrial pathway of apoptosis and eventually increased the sensitivity of bladder cancer cells to CDDP.

  9. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (show AREG Antibodies) and Egfr (show EGFR Antibodies) activity.

  10. LRIG1 is frequently methylated in human CRC (show CALR Antibodies) and consequent mRNA and protein downregulation may contribute to tumor growth by activating EGFR (show EGFR Antibodies)/AKT (show AKT1 Antibodies) signaling

Mouse (Murine) Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) interaction partners

  1. LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin

  2. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (show AREG Antibodies) and Egfr (show EGFR Antibodies) activity.

  3. LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice.

  4. Loss of one Apc (show APC Antibodies) allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis.

  5. At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia.

  6. LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3 (show STAT3 Antibodies).

  7. A review summarizes the data that LRIG1 is a ERBB (show EGFR Antibodies) negative regulator and tumour suppressor.

  8. LRIG1 Loss of heterozygosity (LOH) is frequent across cancers and its loss is an early event in the development of human squamous carcinomas.

  9. The Lrig1, a negative-feedback regulator of the ErbB (show EGFR Antibodies) receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling.

  10. Study demonstrates that Lrig1 null mice develop duodenal adenomas, providing in vivo evidence that the ErbB (show EGFR Antibodies) negative regulator Lrig1 functions as a tumor suppressor.

Lrig1 Antigen Profile

Protein Summary

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).

Gene names and symbols associated with Lrig1

  • leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) antibody
  • leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) antibody
  • D6Bwg0781e antibody
  • Img antibody
  • LIG-1 antibody
  • LIG1 antibody

Protein level used designations for Lrig1

leucine-rich repeat protein LRIG1 , leucine-rich repeats and immunoglobulin-like domains protein 1 , ortholog of mouse integral membrane glycoprotein LIG-1 , integral membrane glycoprotein

GENE ID SPECIES
26018 Homo sapiens
16206 Mus musculus
312574 Rattus norvegicus
Selected quality suppliers for anti-Lrig1 (Lrig1) Antibodies
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