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Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) ELISA Kits

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).. Additionally we are shipping Lrig1 Antibodies (40) and Lrig1 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Lrig1 26018 Q96JA1
Anti-Mouse Lrig1 Lrig1 16206 P70193
Anti-Rat Lrig1 Lrig1 312574  
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Top Lrig1 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 0.039 ng/ml 0.156-10 ng/mL 96 Tests Log in to see 11 to 13 Days
$910.56
Details

More ELISA Kits for Lrig1 Interaction Partners

Human Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) interaction partners

  1. ERa-dependent expression of LRIG1 dampens ErbB3 (show ERBB3 ELISA Kits) signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 (show ERBB3 ELISA Kits) accumulation, enhanced ErbB3 (show ERBB3 ELISA Kits) signaling to cell survival pathways

  2. These findings demonstrate that LRIG1 is an independent prognostic factor in patients with non-small cell lung cancer

  3. LRIG1 expression was associated with pathological type, differentiation status, and stage of Non-small Cell Lung Cancer. The result showed that LRIG1 was an independent prognostic factor for OS of NSCLC patients.

  4. The inhibitory effects of LRIG1 are most likely mediated by suppression of the EGFR (show EGFR ELISA Kits)/PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) pathway and epithelial-mesenchymal transition (EMT (show ITK ELISA Kits)) process.

  5. LRIG1 can enhance chemosensitivity in glioblastoma by inhibition of BCL-2 (show BCL2 ELISA Kits) and MnSOD (show SOD2 ELISA Kits)

  6. Results showed that leucine-rich repeats and immunoglobulin-like domains can reverse multidrug resistance in glioblastoma, by negatively regulating epidermal growth factor receptor (show EGFR ELISA Kits).

  7. MiR (show MLXIP ELISA Kits)-20a mediated temozolomide-resistance in glioblastoma cells through negatively regulating LRIG1 expression.

  8. Based on these results, we concluded that the upregulation of LRIG1 expression inhibited the EGFR (show EGFR ELISA Kits) signaling pathway, activated the mitochondrial pathway of apoptosis and eventually increased the sensitivity of bladder cancer cells to CDDP.

  9. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (show AREG ELISA Kits) and Egfr (show EGFR ELISA Kits) activity.

  10. LRIG1 is frequently methylated in human CRC (show CALR ELISA Kits) and consequent mRNA and protein downregulation may contribute to tumor growth by activating EGFR (show EGFR ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling

Mouse (Murine) Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) interaction partners

  1. LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin

  2. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (show AREG ELISA Kits) and Egfr (show EGFR ELISA Kits) activity.

  3. LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice.

  4. Loss of one Apc (show APC ELISA Kits) allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis.

  5. At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia.

  6. LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3 (show STAT3 ELISA Kits).

  7. A review summarizes the data that LRIG1 is a ERBB (show EGFR ELISA Kits) negative regulator and tumour suppressor.

  8. LRIG1 Loss of heterozygosity (LOH) is frequent across cancers and its loss is an early event in the development of human squamous carcinomas.

  9. The Lrig1, a negative-feedback regulator of the ErbB (show EGFR ELISA Kits) receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling.

  10. Study demonstrates that Lrig1 null mice develop duodenal adenomas, providing in vivo evidence that the ErbB (show EGFR ELISA Kits) negative regulator Lrig1 functions as a tumor suppressor.

Lrig1 Antigen Profile

Antigen Summary

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).

Gene names and symbols associated with Lrig1

  • leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) antibody
  • leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) antibody
  • D6Bwg0781e antibody
  • Img antibody
  • LIG-1 antibody
  • LIG1 antibody

Protein level used designations for Lrig1

leucine-rich repeat protein LRIG1 , leucine-rich repeats and immunoglobulin-like domains protein 1 , ortholog of mouse integral membrane glycoprotein LIG-1 , integral membrane glycoprotein

GENE ID SPECIES
26018 Homo sapiens
16206 Mus musculus
312574 Rattus norvegicus
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