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Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 Proteins (Lrig1)

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).. Additionally we are shipping Lrig1 Antibodies (40) and Lrig1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Lrig1 26018 Q96JA1
Lrig1 16206 P70193
Rat Lrig1 Lrig1 312574  
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Top Lrig1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$841.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

Lrig1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) , ,
,

Top referenced Lrig1 Proteins

  1. Mouse (Murine) Lrig1 Protein expressed in Human Cells - ABIN2007914 : Thomasson, Wang, Hammarsten, Dahlman, Persson, Josefsson, Stattin, Granfors, Egevad, Henriksson, Bergh, Hedman: LRIG1 and the liar paradox in prostate cancer: a study of the expression and clinical significance of LRIG1 in prostate cancer. in International journal of cancer. Journal international du cancer 2011 (PubMed)

More Proteins for Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) Interaction Partners

Human Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) interaction partners

  1. ERa-dependent expression of LRIG1 dampens ErbB3 (show ERBB3 Proteins) signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 (show ERBB3 Proteins) accumulation, enhanced ErbB3 (show ERBB3 Proteins) signaling to cell survival pathways

  2. These findings demonstrate that LRIG1 is an independent prognostic factor in patients with non-small cell lung cancer

  3. LRIG1 expression was associated with pathological type, differentiation status, and stage of Non-small Cell Lung Cancer. The result showed that LRIG1 was an independent prognostic factor for OS of NSCLC patients.

  4. The inhibitory effects of LRIG1 are most likely mediated by suppression of the EGFR (show EGFR Proteins)/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway and epithelial-mesenchymal transition (EMT (show ITK Proteins)) process.

  5. LRIG1 can enhance chemosensitivity in glioblastoma by inhibition of BCL-2 (show BCL2 Proteins) and MnSOD (show SOD2 Proteins)

  6. Results showed that leucine-rich repeats and immunoglobulin-like domains can reverse multidrug resistance in glioblastoma, by negatively regulating epidermal growth factor receptor (show EGFR Proteins).

  7. MiR (show MLXIP Proteins)-20a mediated temozolomide-resistance in glioblastoma cells through negatively regulating LRIG1 expression.

  8. Based on these results, we concluded that the upregulation of LRIG1 expression inhibited the EGFR (show EGFR Proteins) signaling pathway, activated the mitochondrial pathway of apoptosis and eventually increased the sensitivity of bladder cancer cells to CDDP.

  9. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (show AREG Proteins) and Egfr (show EGFR Proteins) activity.

  10. LRIG1 is frequently methylated in human CRC (show CALR Proteins) and consequent mRNA and protein downregulation may contribute to tumor growth by activating EGFR (show EGFR Proteins)/AKT (show AKT1 Proteins) signaling

Mouse (Murine) Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) interaction partners

  1. LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin

  2. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (show AREG Proteins) and Egfr (show EGFR Proteins) activity.

  3. LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice.

  4. Loss of one Apc (show APC Proteins) allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis.

  5. At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia.

  6. LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3 (show STAT3 Proteins).

  7. A review summarizes the data that LRIG1 is a ERBB (show EGFR Proteins) negative regulator and tumour suppressor.

  8. LRIG1 Loss of heterozygosity (LOH) is frequent across cancers and its loss is an early event in the development of human squamous carcinomas.

  9. The Lrig1, a negative-feedback regulator of the ErbB (show EGFR Proteins) receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling.

  10. Study demonstrates that Lrig1 null mice develop duodenal adenomas, providing in vivo evidence that the ErbB (show EGFR Proteins) negative regulator Lrig1 functions as a tumor suppressor.

Lrig1 Protein Profile

Protein Summary

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).

Gene names and symbols associated with Lrig1

  • leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1)
  • leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)
  • D6Bwg0781e protein
  • Img protein
  • LIG-1 protein
  • LIG1 protein

Protein level used designations for Lrig1

leucine-rich repeat protein LRIG1 , leucine-rich repeats and immunoglobulin-like domains protein 1 , ortholog of mouse integral membrane glycoprotein LIG-1 , integral membrane glycoprotein

GENE ID SPECIES
26018 Homo sapiens
16206 Mus musculus
312574 Rattus norvegicus
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